{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T15:05:35Z","timestamp":1648998335870},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2020,10]]},"abstract":"\n Allgemein\u2002Jeder Patient mit einem Hypophysentumor soll interdisziplin\u00e4r betreut werden. Obligat sind Vertreter aus Endokrinologie, Neurochirurgie und (Neuro-) Radiologie einzubinden.<\/jats:p>\n Diagnostik\u2002Bei Erstdiagnose eines Hypophysentumors sind Hormonst\u00f6rungen (Exzess- und Mangelsituationen) zuverl\u00e4ssig auszuschlie\u00dfen. Die Magnetresonanztomografie der Sellaregion ist das radiologische Verfahren der Wahl. Eine augen\u00e4rztliche Diagnostik ist nur bei Symptomen oder bei bildmorphologischem Tumorkontakt zur Sehbahn erforderlich.<\/jats:p>\n Therapie\u2002Bei den meisten hormoninaktiven Hypophysentumoren ist eine alleinige Observation m\u00f6glich. Medikament\u00f6se Therapieoptionen bestehen bislang nicht. Ist eine Operation indiziert (z.\u200aB. bei N\u00e4he des Hypophysentumors zur Sehbahn oder bei relevantem Gr\u00f6\u00dfenwachstum), sollte diese durch einen in der Hypophysenchirurgie erfahrenen Neurochirurgen vorgenommen werden. Bei relevanten Rezidiven kommen entweder eine Reoperation oder eine Bestrahlung infrage.<\/jats:p>\n Nachsorge\u2002Eine regelm\u00e4\u00dfige, langfristige und individualisierte Begleitung ist zur Vermeidung potenzieller Komplikationen essenziell. Dabei ist stets zu pr\u00fcfen, ob die diagnostischen Prozesse zu (de-) eskalieren sind.<\/jats:p>\n Schulung und Beratung\u2002Vor allem bei Vorliegen eines gro\u00dfen Hypophysentumors oder nach stattgehabter Operation bzw. Bestrahlung der Sellaregion m\u00fcssen Patienten und deren Umfeld \u00fcber relevante Hormonmangelzust\u00e4nde aufgekl\u00e4rt werden.<\/jats:p>\n Besondere Patientengruppen\u2002In speziellen Situationen (Schwangerschaft, multimorbide und gebrechliche Patienten) muss ggf. vom \u00fcblichen Vorgehen abgewichen werden.<\/jats:p>","DOI":"10.1055\/a-0958-0138","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T22:40:46Z","timestamp":1602024046000},"page":"1444-1449","source":"Crossref","is-referenced-by-count":0,"title":["Hormoninaktive Hypophysentumoren \u2013 Kurzpr\u00e4sentation der ersten deutschen Leitlinie"],"prefix":"10.1055","volume":"145","author":[{"given":"Timo","family":"Deutschbein","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg, Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, W\u00fcrzburg"},{"name":"Medicover Oldenburg MVZ, Oldenburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Jaursch-Hancke","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik, Schwerpunkt Endokrinologie, Diabetes und Stoffwechsel, Wiesbaden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg, Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11102-018-0869-3","article-title":"Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas","volume":"21","author":"G Ntali","year":"2018","journal-title":"Pituitary"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-16-0041","article-title":"Analysis and natural history of pituitary incidentalomas","volume":"175","author":"S A Imran","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: an endocrine society clinical practice guideline","volume":"96","author":"P U Freda","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ando.2015.04.002","article-title":"Management of clinically non-functioning pituitary adenoma","volume":"76","author":"P Chanson","year":"2015","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11102-018-0904-4","article-title":"The experience with transsphenoidal surgery and its importance to outcomes","volume":"21","author":"J Honegger","year":"2018","journal-title":"Pituitary"},{"key":"ref8","first-page":"29","article-title":"Consensus on Postoperative Recommendations After Transsphenoidal Surgery","volume":"127","author":"U J Knappe","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref9","first-page":"36","article-title":"Wie verhalte ich mich richtig im Notfall?'' Deutschlandweites Schulungsprogramm f\u00fcr Patienten mit chronischer Nebenniereninsuffizienz","volume":"48","author":"A Eff","year":"2019","journal-title":"GLANDULA"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0958-0138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T22:40:55Z","timestamp":1602024055000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0958-0138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":7,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2020,10,6]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0958-0138","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}