{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:08:39Z","timestamp":1761419319652},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies report neurological complications such as brain injury induced by ischemia or edema following exhaustive endurance sport. We aimed to detect the frequency of acute brain lesions after a marathon race. In the prospective observational Berlin Beat of Running study, 110 experienced endurance athletes underwent 3-Tesla brain MRI exams 2\u20133 days prior and within 2 days after a marathon run. MRI results were compared to an age- and sex-matched control group of 68 non-athletes, including the \u201cAge-Related White Matter Changes\u201d (ARWMC) scale to assess white matter lesions (WML) in the brain. 108 athletes (median age 48 years, 24% female, 8% with hypertension; 0% with diabetes) completed the race. No athlete reported neurological deficits, but a single acute ischemic lesion was detected in diffusion-weighted MRI after the race in one athlete. No other acute brain lesions compared to prior MRI were found. An ARWMC score \u22654 was found in 15% of athletes and 12% of non-athletic controls (p=0.7). Chronic ischemic lesions were not found in athletes but in four controls (6%) (p=0.02). In conclusion, acute ischemic brain lesions may be found in endurance runners. Every seventh endurance athlete and every ninth control showed evidence for substantial white matter lesions.<\/jats:p>","DOI":"10.1055\/a-0958-9548","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T22:56:10Z","timestamp":1568156170000},"page":"856-862","source":"Crossref","is-referenced-by-count":8,"title":["MRI Brain Changes After Marathon Running: Results of the Berlin Beat of Running Study"],"prefix":"10.1055","volume":"40","clinical-trial-number":[{"clinical-trial-number":"nct01428778","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Juliane","family":"Herm","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Georg","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Kunze","sequence":"additional","affiliation":[{"name":"Center for Stroke Research, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Kr\u00fcll","sequence":"additional","affiliation":[{"name":"SMS Medical Institute Berlin GmbH, Berlin, Germany"},{"name":"SCC EVENTS GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brechtel","sequence":"additional","affiliation":[{"name":"Carl Remigius Medical School, Physician Assistance, Hamburg, Germany"},{"name":"Berlin Academy of Sports Medicine, Sports Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Lock","sequence":"additional","affiliation":[{"name":"SMS Medical Institute Berlin GmbH, Berlin, Germany"},{"name":"SCC EVENTS GmbH, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter U.","family":"Heuschmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology and Biometry, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Clinical Trial Center W\u00fcrzburg, University of W\u00fcrzburg, W\u00fcrzburg, Germany"},{"name":"Comprehensive Heart Failure Center, University of W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Haverkamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Heekeren","sequence":"additional","affiliation":[{"name":"Department of Education and Psychology, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Liman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9, Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Stroke Research, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Excellence Cluster NeuroCure, Berlin, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen B.","family":"Fiebach","sequence":"additional","affiliation":[{"name":"Center for Stroke Research, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard Jan","family":"Jungehulsing","sequence":"additional","affiliation":[{"name":"Department of Neurology, J\u00fcdisches Krankenhaus Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,10]]},"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0958-9548.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T11:51:10Z","timestamp":1576669870000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0958-9548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":0,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,12,1]]},"published-print":{"date-parts":[[2019,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0958-9548","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]}}}