{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:20:31Z","timestamp":1777368031628,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiat Prax"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die klinische Relevanz der Medikamenteninteraktion zwischen Valproat und Metamizol soll anhand eines Patientenfalls aus der Gerontopsychiatrie dargestellt werden. Es besteht die Annahme, dass Metamizol in der Dosierung von 4\u200ag\/d einen relevanten Einfluss auf den Valproatspiegel und das klinische Outcome hat. Dies k\u00f6nnte auf einer CYP2B6-Induktion und gesteigerten Metabolisierung des Valproats beruhen. Im Falle einer Kombinationsbehandlung von Valproat mit Metamizol sind somit engmaschige Kontrollen des Valproatspiegels zu empfehlen.<\/jats:p>","DOI":"10.1055\/a-0961-5266","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T22:52:53Z","timestamp":1565823173000},"page":"94-97","source":"Crossref","is-referenced-by-count":1,"title":["Medikament\u00f6se Komplextherapie \u2013 Arzneimittelinteraktionen von Valproat und Metamizol"],"prefix":"10.1055","volume":"47","author":[{"given":"Anna","family":"Kliem","sequence":"additional","affiliation":[{"name":"Asklepios Klinik Barmbek (Hamburg)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Green","sequence":"additional","affiliation":[{"name":"Klinikapotheke, Universit\u00e4tsklinikum Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Mattern","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemeine Psychiatrie, Universit\u00e4tsklinikum Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,8,14]]},"container-title":["Psychiatrische Praxis"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0961-5266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T23:38:52Z","timestamp":1583797132000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0961-5266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,14]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,3,9]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0961-5266","relation":{},"ISSN":["0303-4259","1439-0876"],"issn-type":[{"value":"0303-4259","type":"print"},{"value":"1439-0876","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,14]]}}}