{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:59:50Z","timestamp":1790247590574,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Purpose\u2002Clinically significant portal hypertension (CSPH) is responsible for most of the complications in patients with cirrhosis. Liver stiffness (LS) measurement by vibration-controlled transient elastography (VCTE) is currently used to evaluate CSPH. Bi-dimensional shear wave elastography from General Electric (2D-SWE.GE) has not yet been validated for the diagnosis of PHT. Our aims were to test whether 2D-SWE.GE-LS is able to evaluate CSPH, to determine the reliability criteria of the method and to compare its accuracy with that of VCTE-LS in this clinical setting.<\/jats:p><jats:p>Materials and Methods\u2002Patients with chronic liver disease referred to hepatic catheterization (HVPG) were consecutively enrolled. HVPG and LS by both VCTE and 2D-SWE.GE were performed on the same day. The diagnostic performance of each LS method was compared against HVPG and between each other.<\/jats:p><jats:p>Results\u20022D-SWE.GE-LS was possible in 123\/127 (96.90\u200a%) patients. The ability to record at least 5 LS measurements by 2D-SWE.GE and IQR\u200a&lt;\u200a30\u200a% were the only features associated with reliable results. 2D-SWE.GE-LS was highly correlated with HVPG (r\u200a=\u200a0.704; p\u200a&lt;\u200a0.0001), especially if HVPG &lt;\u200a10\u200ammHg and was significantly higher in patients with CSPH (15.52 vs. 8.14\u200akPa; p\u200a&lt;\u200a0.0001). For a cut-off value of 11.3\u200akPa, the AUROC of 2D-SWE.GE-LS to detect CSPH was 0.91, which was not inferior to VCTE-LS (0.92; p\u200a=\u200a0.79). The diagnostic accuracy of LS by 2D-SWE.GE-LS to detect CSPH was similar with the one of VCTE-LS (83.74\u200a% vs. 85.37\u200a%; p\u200a=\u200a0.238). The diagnostic accuracy was not enhanced by using different cut-off values which enhanced the sensitivity or the specificity. However, in the subgroup of compensated patients with alcoholic liver disease, 2D-SWE.GE-LS classified CSPH better than VCTE-LS (93.33\u200a% vs. 85.71\u200a%, p\u200a=\u200a0.039).<\/jats:p><jats:p>Conclusion\u20022D-SWE.GE-LS has good accuracy, not inferior to VCTE-LS, for the diagnosis of CSPH.<\/jats:p>","DOI":"10.1055\/a-0965-0745","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T23:19:29Z","timestamp":1567466369000},"page":"526-533","source":"Crossref","is-referenced-by-count":24,"title":["Liver Stiffness Assessed by Ultrasound Shear Wave Elastography from General Electric Accurately Predicts Clinically Significant Portal Hypertension in Patients with Advanced Chronic Liver Disease"],"prefix":"10.1055","volume":"41","author":[{"given":"Horia","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Hepatology Department, Regional Institute of Gastroenterology and Hepatology, Cluj Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Rusu","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lupsor-Platon","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Nicoara Farcau","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Fischer","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crina","family":"Grigoras","sequence":"additional","affiliation":[{"name":"Hepatology Department, Regional Institute of Gastroenterology and Hepatology, Cluj Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Horhat","sequence":"additional","affiliation":[{"name":"Hepatology Department, Regional Institute of Gastroenterology and Hepatology, Cluj Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana","family":"Stancu","sequence":"additional","affiliation":[{"name":"Central Military Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Ardelean","sequence":"additional","affiliation":[{"name":"Hepatology Department, Regional Institute of Gastroenterology and Hepatology, Cluj Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Tantau","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Badea","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[{"name":"Hepatology Department, Regional Institute of Gastroenterology and Hepatology, Cluj Napoca, Romania"},{"name":"3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"},{"name":"Liver Research Club, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jhep.2008.01.021","article-title":"The management of portal hypertension: Rational basis, available treatments and future options","volume":"48","author":"J Bosch","year":"2008","journal-title":"J\u00a0Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/j.1572-0241.2004.30754.x","article-title":"The Cost-Effectiveness of Hepatic Venous Pressure Gradient Monitoring in the Prevention of Recurrent Variceal Hemorrhage","volume":"99","author":"L E Targownik","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"J Bosch","year":"2009","journal-title":"Nat Rev Gastroenterol Hepatol Nature Publishing Group"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2015.04.006","article-title":"EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis","volume":"63","author":"L Castera","year":"2015","journal-title":"J Hepatol"},{"key":"ref5","first-page":"743","article-title":"Expanding consensus in portal hypertension Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension","volume":"63","author":"R D Franchis","year":"2015","journal-title":"J Hepatol European Association for the Study of the Liver"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1365-2036.2008.03701.x","article-title":"Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease","volume":"27","author":"C Bureau","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jhep.2011.01.051","article-title":"Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease: a prospective study","volume":"55","author":"M A Robic","year":"2011","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cgh.2013.07.034","article-title":"Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: A systematic review and meta-analysis","volume":"11","author":"S Singh","year":"2013","journal-title":"Clin Gastroenterol Hepatol Elsevier, Inc"},{"key":"ref9","first-page":"828","article-title":"Pitfalls of liver stiffness measurement: a 5-year prospective study of 13369 examinations","volume":"51","author":"L Cast\u00e9ra","year":"2010","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.11152\/mu-910","article-title":"Performance of 2D-SWE.GE for predicting different stages of liver fibrosis, using Transient Elastography as the reference method","volume":"19","author":"F Bende","year":"2017","journal-title":"Med Ultrason"},{"key":"ref11","first-page":"807","article-title":"An extension of STARD statements for reporting diagnostic accuracy studies on liver fibrosis tests: The Liver-FibroSTARD standards","volume":"62","author":"J Boursier","year":"2015","journal-title":"J Hepatol European Association for the Study of the Liver"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/hep.26343","article-title":"Liver stiffness is influenced by a standardized meal in patients with chronic hepatitis C virus at different stages of fibrotic evolution","volume":"58","author":"U Arena","year":"2013","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e58742","DOI":"10.1371\/journal.pone.0058742","article-title":"Effect of meal ingestion on\u00a0liver stiffness in patients with cirrhosis and portal hypertension","volume":"8","author":"A Berzigotti","year":"2013","journal-title":"PLoS\u00a0One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/jum.14862","article-title":"Reproducibility of 2 Liver 2\u2010Dimensional Shear Wave Elastographic Techniques in the Fasting and Postprandial States","volume":"38","author":"P Simkin","year":"2018","journal-title":"J Ultrasound Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/hep.20506","article-title":"Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C","volume":"41","author":"M Ziol","year":"2005","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/hep.25993","article-title":"Determination of reliability criteria for liver stiffness evaluation by transient elastography","volume":"57","author":"J Boursier","year":"2013","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/bimj.200410135","article-title":"Estimation of the Youden Index and its Associated Cutoff Point","volume":"47","author":"R Fluss","year":"2005","journal-title":"Biometrical J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/hep.21665","article-title":"Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis","volume":"45","author":"F Vizzutti","year":"2007","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/hep.29363","article-title":"Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease","volume":"66","author":"S Augustin","year":"2017","journal-title":"Hepatology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1148\/radiol.14141210","article-title":"Prospective Comparison of Spleen and Liver Stiffness by Using Shear-Wave and Transient Elastography for Detection of Portal Hypertension in Cirrhosis","volume":"275","author":"L Elkrief","year":"2015","journal-title":"Radiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jhep.2014.12.007","article-title":"Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension","volume":"62","author":"B Procopet","year":"2015","journal-title":"J Hepatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ultrasmedbio.2017.10.013","article-title":"Assessing Liver Stiffness by 2-D Shear Wave Elastography in a Healthy Cohort","volume":"44","author":"F Bende","year":"2018","journal-title":"Ultrasound Med Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/MEG.0000000000000846","article-title":"Two-dimensional shear-wave elastography","volume":"29","author":"B Schellhaas","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1055\/s-0041-107971","article-title":"Evaluation of liver and spleen stiffness with acoustic radiation force impulse quantification elastography for diagnosing clinically significant portal hypertension","volume":"36","author":"D Attia","year":"2015","journal-title":"Ultraschall der Medizin"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/liv.13243","article-title":"Shear-wave elastography of the liver and spleen identifies clinically significant portal hypertension: A prospective multicentre study","volume":"37","author":"C Jansen","year":"2017","journal-title":"Liver Int"},{"key":"ref26","first-page":"399","article-title":"Non-invasive evaluation of portal hypertension using ultrasound elastography","volume":"67","author":"A Berzigotti","year":"2017","journal-title":"In: Journal of Hepatology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/hep.28824","article-title":"Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The \u201cAnticipate\u201d study","volume":"64","author":"J G Abraldes","year":"2016","journal-title":"Hepatology"},{"key":"ref28","first-page":"16","article-title":"EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version) EFSUMB-Leitlinien und Empfehlungen zur klinischen Anwendung der Leberelastographie, Update 2017 (Langversion).","volume":"38","author":"A F Christoph Dietrich","year":"2017","journal-title":"Ultraschall in Med"},{"key":"ref29","first-page":"213","article-title":"Point shear wave ultrasound elastography with Esaote compared to real-time 2D shear wave elastography with supersonic imagine for the quantification of liver stiffness","volume":"20","author":"L Mulazzani","year":"2017","journal-title":"J\u00a0Ultrasound"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.dld.2017.03.001","article-title":"Differences in liver stiffness values obtained with new ultrasound elastography machines and Fibroscan: A comparative study","volume":"49","author":"F Piscaglia","year":"2017","journal-title":"Dig Liver Dis"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1055\/a-0651-0542","article-title":"Comparison of Liver Shear Wave Elastography Measurements using Siemens Acuson S3000, GE LOGIQ E9, Philips EPIQ7 and Toshiba Aplio 500 (Software Versions 5.0 and 6.0) in Healthy Volunteers","author":"V Gress","year":"2018","journal-title":"Ultraschall der Medizin \u2013 Eur J Ultrasound"}],"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0965-0745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:03:20Z","timestamp":1610928200000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0965-0745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":31,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,10,5]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0965-0745","relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]}}}