{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:59:26Z","timestamp":1783072766569,"version":"3.54.6"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002To investigate the effects of the antenatal administration of betamethasone on fetal Doppler and short term fetal heart rate variation (CTG-STV) in early growth restricted (FGR) fetuses.<\/jats:p><jats:p>\n          Materials and Methods\u2002Post hoc analysis of data derived from the TRUFFLE study, a prospective, multicenter, randomized management trial of severe early onset FGR. Repeat Doppler and CTG-STV measurements between the last recording within 48 hours before the first dose of betamethasone (baseline value) and for 10 days after were evaluated. Multilevel analysis was performed to analyze the longitudinal course of the umbilico-cerebral ratio (UC ratio), the ductus venosus pulsatility index (DVPIV) and CTG-STV.<\/jats:p><jats:p>\n          Results\u2002We included 115 fetuses. A significant increase from baseline in CTG-STV was found on day +\u200a1 (p\u200a=\u200a0.019) but no difference thereafter. The DVPIV was not significantly different from baseline in any of the 10 days following the first dose of betamethasone (p\u200a=\u200a0.167). Multilevel analysis revealed that, over 10 days, the time elapsed from antenatal administration of betamethasone was significantly associated with a decrease in CTG-STV (p\u200a=\u200a0.045) and an increase in the DVPIV (p\u200a=\u200a0.001) and UC ratio (p\u200a&lt;\u200a0.001).<\/jats:p><jats:p>\n          Conclusion\u2002Although steroid administration in early FGR has a minimal effect on increasing CTG-STV one day afterwards, the effects on Doppler parameters were extremely slight with regression coefficients of small magnitude suggesting no clinical significance, and were most likely related to the deterioration with time in FGR. Hence, arterial and venous Doppler assessment of fetal health remains informative following antenatal steroid administration to accelerate fetal lung maturation.<\/jats:p>","DOI":"10.1055\/a-0972-1098","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T23:19:29Z","timestamp":1567466369000},"page":"56-64","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Antenatal Betamethasone on Fetal Doppler Indices and\u00a0Short Term Fetal Heart Rate Variation in Early Growth Restricted\u00a0Fetuses"],"prefix":"10.1055","volume":"42","author":[{"given":"Nicola","family":"Fratelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Brescia, Spedali Civili di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Prefumo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Brescia, Spedali Civili di Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Hecher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Medical Center, Hamburg-Eppendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard H. A.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine, University of Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Giussani","sequence":"additional","affiliation":[{"name":"Department of Physiology Development & Neuroscience, University of Cambridge, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine, University of Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Frusca","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology Unit, University of Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Ghi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology Unit, University of Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ferrazzi","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Buzzi, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph C.","family":"Lees","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Imperial College London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the TRUFFLE Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TRUFFLE Group authors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TRUFFLE Group collaborating authors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"ref1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"D Roberts","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.siny.2008.10.003","article-title":"Antenatal corticosteroid therapy: short-term effects on fetal behaviour and haemodynamics","volume":"14","author":"E J Mulder","year":"2009","journal-title":"Semin Fetal Neonatal 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