{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:20:59Z","timestamp":1792686059089,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, the Graves\u02bc Recurrent Events After Therapy score (GREAT) was proposed as a useful tool to predict relapse before starting antithyroid drugs (ATD) in patients with Graves\u02bc disease (GD). Therefore, we intended to assess the validity of the GREAT score in Turkish patients with GD, including patients who experienced a poorly controlled disease (multiple episodes of hyperthyroidism followed by euthyroidism or rarely hypothyroidism) during ATD dose titration. This is a retrospective multicenter study including 517 patients with the first episode of GD who were treated for at least 12 months. The patients were classified as relapse+poorly controlled disease (non-remission) and remission groups. During a median follow-up time of 35 months (12\u2013144 months), 191 (37%) patients experienced a relapse, 136 (26.3%) a poorly controlled disease, and 190 (36.7%) remained in remission. Patients with non-remission disease tended to have significantly higher serum levels of TRAb, fT4, and fT3, and have larger goiter sizes on palpation at baseline, as compared with the remission group. Non-remission disease occurred in 12, 35, and, 53% of the patients falling into GREAT class I, II, and III, respectively (hazard ratio 2.56, 95% CI 2.02\u20133.51, p=0.012, and hazard ratio 3.54, 95% CI 2.12\u20135.91, p&lt;0.001, for GREAT class II and III against class I, respectively). According to our study, the GREAT score is a useful tool to predict the risk of relapse as well as the occurrence of poorly controlled disease before starting treatment with ATDs.<\/jats:p>","DOI":"10.1055\/a-0974-3991","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T22:41:40Z","timestamp":1568068900000},"page":"627-633","source":"Crossref","is-referenced-by-count":17,"title":["External Validation of the GREAT Score in Turkish Patients with Graves\u02bc Hyperthyroidism Treated with the Titration Regimen Method of Antithyroid Drugs: A Multicenter Study"],"prefix":"10.1055","volume":"51","author":[{"given":"Sayid Shafi","family":"Zuhur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Elbuken","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"Kadioglu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvinaz","family":"Erol","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Kilinc","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Firat University, Elazig, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulhan","family":"Akbaba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birol","family":"Topcu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuksel","family":"Altuntas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,9]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0974-3991.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T22:31:41Z","timestamp":1570055501000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0974-3991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,9]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,2]]},"published-print":{"date-parts":[[2019,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0974-3991","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,9]]}}}