{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:08Z","timestamp":1787004848226,"version":"build-2736575974"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose To assess the accuracy of bilateral inferior petrosal sinus sampling both in the differential diagnosis of adrenocorticotrophic hormone dependent Cushing\u2019s syndrome and predicting the localization on the pituitary.<\/jats:p>\n                  <jats:p>Methods The authors evaluated all patients that undergone bilateral inferior petrosal sinus sampling in a tertiary centre, between January 1995 and March 2018. The probable diagnosis of Cushing\u2019s disease was made when the basal central\/peripheral gradient was&gt;2 and\/or&gt;3 after stimulation with corticotrophin releasing hormone. The localization was suggested when the inter-sinus gradient was&gt;1.4. The results obtained were compared with the post operatory results: compatible histology and positive immunohistochemistry to adrenocorticotrophic hormone and\/or the presence of criteria of cure. Sensitivity, specificity and predictive positive value were calculated.<\/jats:p>\n                  <jats:p>Results A total of 49 patients were evaluated (75.5% female; mean age 45.4\u00b116.3 years old). Bilateral inferior petrosal sinus sampling was compatible with Cushing\u2019s disease in 27 out of 28 confirmed cases in histology or by criteria of cure, and was compatible with ectopic secretion in the 2 cases confirmed as ectopic secretion of adrenocorticotrophic hormone (sensitivity 96.4%; specificity 100%). The lateralization calculated was concordant with the results after surgery in 17 out of 27 patients with Cushing\u2019s disease \u2013 predictive positive value of 63%. Magnetic resonance had a higher predictive value to lateralization \u2013 70.0%.<\/jats:p>\n                  <jats:p>Conclusions Bilateral inferior petrosal sinus sampling is a safe and reliable procedure to diagnose Cushing\u2019s disease, with great sensitivity and specificity. Nevertheless, the capacity of this procedure to lateralize the lesion inside the pituitary is limited.<\/jats:p>","DOI":"10.1055\/a-0981-5973","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T19:01:00Z","timestamp":1566241260000},"page":"126-130","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic accuracy of Bilateral Inferior Petrosal Sinus Sampling: The Experience of a Tertiary Centre"],"prefix":"10.1055","volume":"129","author":[{"given":"Catarina A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viriato","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar e Universit\u00e1rio do Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing\u2019s syndrome","volume":"367","author":"J Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/cncr.20412","article-title":"The prevalence of pituitary adenomas: a systematic review","volume":"101","author":"S Ezzat","year":"2004","journal-title":"Cancer"},{"key":"ref3","first-page":"132","article-title":"The role of bilateral inferior petrosal sinus sampling in the diagnostic evaluation of Cushing syndrome","volume":"18","author":"A Deipolyi","year":"2012","journal-title":"Diagn Interv Radiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1530\/EC-16-0029","article-title":"Bilateral inferior petrosal sinus sampling","volume":"5","author":"B Zampetti","year":"2016","journal-title":"Endocr Connect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1530\/eje.0.1440499","article-title":"Inferior petrosal sinus sampling in the differential diagnosis of Cushing\u2019s syndrome: results of an Italian multicenter study","volume":"144","author":"A Colao","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1056\/NEJM199109263251301","article-title":"Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing\u2019s syndrome","volume":"325","author":"E H Oldfield","year":"1991","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1210\/jc.2002-020374","article-title":"Accuracy of bilateral inferior petrosal or cavernous sinuses sampling in predicting the lateralization of Cushing\u2019s disease pituitary microadenoma: influence of catheter position and anatomy of venous drainage","volume":"88","author":"V Lefournier","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1210\/jc.2012-3943","article-title":"The lateralization accuracy of inferior petrosal sinus sampling in 501 patients with Cushing\u2019s disease","volume":"98","author":"J J Wind","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","first-page":"647","article-title":"The diagnosis and differential diagnosis of Cushing\u2019s syndrome and pseudo-Cushing\u2019s states","volume":"19","author":"J Newell-Price","year":"1998","journal-title":"Endocr Rev."},{"key":"ref10","first-page":"440","article-title":"Diagnosis and management of Cushing\u2019s syndrome: results of an Italian multicentre study. 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diagnosis of adrenocorticotropin (ACTH)-dependent Cushing\u2019s syndrome: early recognition of the occult ectopic ACTH syndrome","volume":"73","author":"J W Findling","year":"1991","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0981-5973.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T01:46:05Z","timestamp":1721612765000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0981-5973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,19]]},"references-count":41,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,2,1]]},"published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0981-5973","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,19]]}}}