{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:52:51Z","timestamp":1771879971307,"version":"3.50.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Antibiotikaverbrauch in Deutschland\u2002In Deutschland wurden in den letzten Jahren sowohl im Krankenhausbereich als auch im ambulanten Setting immer weniger Fluorchinolone verordnet. Auch der Verbrauch der Cephalosporine ging etwas zur\u00fcck.<\/jats:p><jats:p>\n          Renaissance von Aminoglykosiden?\u2002Die inzwischen relativ seltenen Substanzen k\u00f6nnen aufgrund einer recht guten Resistenzlage bei Harnwegsinfektionen als geeignete Alternative \u2013 allerdings nur parenteral \u2013 eingesetzt werden. Bei akuten schweren Infektionen ist eine einmalige Gabe, z.\u200aB. von Tobramycin, initial zus\u00e4tzlich zu einem geeigneten Betalactam ebenfalls eine Option, aber keine klare Empfehlung.<\/jats:p><jats:p>\n          Antibiotikaeinsatz in der H\u00e4matologie\/Onkologie\u2002Bei Fieber und Neutropenie gilt nach wie vor die initiale empirische Gabe von Piperacillin-Tazobactam oder einem pseudomonasaktiven Carbapenem als Standard. Diese Betalactame sollten mit verl\u00e4ngerter Infusionsdauer, z.\u200aB. \u00fcber 4\u200ah, verabreicht werden. Linezolid ist ein Reservemedikament und sollte auch bei h\u00e4matoonkologischen Patienten nicht empirisch, sondern nur in der gezielten Therapie verwendet werden.<\/jats:p><jats:p>\n          Penicillinallergie\u2002Die anamnestische Angabe einer Penicillinallergie sollte durch genaues Hinterfragen differenziert werden. Patienten k\u00f6nnen so bez\u00fcglich ihres Risikos f\u00fcr allergische Reaktionen gruppiert werden \u2013 oft besteht kein oder ein sehr geringes Risiko bei einer (erneuten) Behandlung mit Penicillinderivaten. Niedrigrisikopatienten d\u00fcrfen ohne weitergehende allergologische Untersuchungen reexponiert werden.<\/jats:p>","DOI":"10.1055\/a-0982-8842","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T23:48:40Z","timestamp":1606780120000},"page":"1758-1763","source":"Crossref","is-referenced-by-count":6,"title":["Aktuelle Entwicklungen im Bereich Antibiotic Stewardship"],"prefix":"10.1055","volume":"145","author":[{"given":"Winfried V.","family":"Kern","sequence":"additional","affiliation":[{"name":"Abteilung Infektiologie, Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Horn","sequence":"additional","affiliation":[{"name":"Abteilung Infektiologie, Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geertje","family":"Fink","sequence":"additional","affiliation":[{"name":"Abteilung Infektiologie, Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"ref5","doi-asserted-by":"crossref","first-page":"e02165-18","DOI":"10.1128\/AAC.02165-18","article-title":"A systematic review of single-dose aminoglycoside therapy for urinary tract infection: is it time to resurrect an old strategy?","volume":"63","author":"K J Goodlet","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e0236864","DOI":"10.1371\/journal.pone.0236864","article-title":"Antibiotic treatment with one single dose of gentamicin at admittance in addition to a \u03b2-lactam antibiotic in the treatment of community-acquired bloodstream infection with sepsis","volume":"15","author":"K L Prytz","year":"2020","journal-title":"PLoS One"},{"key":"ref8","first-page":"155","article-title":"Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection","volume":"110","author":"N D Ritchie","year":"2017","journal-title":"QJM"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/cid\/cix186","article-title":"Short-course adjunctive gentamicin as empirical therapy in patients with severe sepsis and septic shock: a prospective observational cohort study","volume":"64","author":"D SY Ong","year":"2017","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"S1198-743X(20)30269-X","DOI":"10.1016\/j.cmi.2020.04.041","article-title":"Short-course aminoglycosides as adjunctive empirical therapy in patients with Gram-negative bloodstream infection, a cohort study","author":"J WT Deelen","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105839","DOI":"10.1016\/j.ijantimicag.2019.10.020","article-title":"\u03b2-lactam antibiotic versus combined \u03b2-lactam antibiotics and single daily dosing regimens of aminoglycosides for treating serious infections: a\u00a0meta-analysis","volume":"55","author":"A J Heffernan","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001553","article-title":"Aminoglycosides in immunocompromised critically ill patients with bacterial pneumonia and septic shock: a post-hoc analysis of a prospective multicenter multinational cohort","author":"L Ren\u00e9","year":"2020","journal-title":"Shock"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0236864","DOI":"10.1371\/journal.pone.0236864","article-title":"Antibiotic treatment with one single dose of gentamicin at admittance in addition to a \u03b2-lactam antibiotic in the treatment of community-acquired bloodstream infection with sepsis","volume":"15","author":"K Liljedahl Prytz","year":"2020","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","article-title":"Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"96","author":"W J Heinz","year":"2017","journal-title":"Ann Hematol"},{"key":"ref15","first-page":"69","article-title":"A comparison of the\u00a0efficacy of piperacillin-tazobactam and cefoperazone-sulbactam therapies in the empirical treatment of patients with febrile neutropenia","volume":"29","author":"A Aynioglu","year":"2016","journal-title":"Rev Esp Quimioter"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1007\/s00520-018-4260-8","article-title":"Cefepime vs. cefoperazone\/sulbactam in combination with amikacin as empirical antibiotic therapy in febrile neutropenia","volume":"26","author":"M Ponraj","year":"2018","journal-title":"Support Care Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cmi.2017.03.024","article-title":"Comparison of antipseudomonal \u03b2-lactams for febrile neutropenia empiric therapy: systematic review and network meta-analysis","volume":"23","author":"N Horita","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmi.2016.10.019","article-title":"Benzylpenicillin plus an aminoglycoside versus meropenem in neutropenic lymphoma and leukaemia patients with a suspected bacterial infection: a\u00a0randomized, controlled trial","volume":"23","author":"D Torfoss","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/cid\/ciy258","article-title":"Extended vs bolus infusion of broad-spectrum \u03b2-lactams for febrile neutropenia: an unblinded, randomized trial","volume":"67","author":"R Ram","year":"2018","journal-title":"Clin Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijid.2015.02.001","article-title":"Empiric use of linezolid in febrile hematology and hematopoietic stem cell transplantation patients colonized with vancomycin-resistant Enterococcus spp","volume":"33","author":"L F Lisboa","year":"2015","journal-title":"Int J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbmt.2018.11.008","article-title":"Impact of empiric treatment for vancomycin-resistant Enterococcus in colonized patients early after allogeneic hematopoietic stem cell transplantation","volume":"25","author":"M Kamboj","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref22","first-page":"121","article-title":"S2k-Leitlinie: Diagnostik bei Verdacht auf eine Betalaktamantibiotika-\u00dcberempfindlichkeit. Leitlinie der Deutschen Gesellschaft f\u00fcr Allergologie und klinische Immunologie (DGAKI) in Zusammenarbeit mit dem \u00c4rzteverband Deutscher Allergologen (AeDA), der Gesellschaft f\u00fcr P\u00e4diatrische Allergologie und Umweltmedizin (GPA), der Deutschen Kontaktallergiegruppe (DKG), der \u00d6sterreichischen Gesellschaft f\u00fcr Allergologie und Immunologie (\u00d6GAI) und der Paul-Ehrlich-Gesellschaft f\u00fcr Chemotherapie (PEG)","volume":"28","author":"G Wurpts","year":"2019","journal-title":"Allergo J Int"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"E S Shenoy","year":"2019","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/all.13848","article-title":"The challenge of de-labeling penicillin allergy","volume":"75","author":"C A Stone","year":"2020","journal-title":"Allergy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/jamainternmed.2020.2227","article-title":"Association between penicillin allergy documentation and antibiotic use","volume":"180","author":"K G Blumenthal","year":"2020","journal-title":"JAMA Intern Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.37765\/ajmc.2020.42832","article-title":"High-cost, high-need patients: the impact of reported penicillin allergy","volume":"26","author":"K G Blumenthal","year":"2020","journal-title":"Am J Manag Care"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa653","article-title":"The Penicillin Allergy Delabeling Program: a multicenter whole-of-hospital health services intervention and comparative effectiveness study","author":"K YL Chua","year":"2020","journal-title":"Clin Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamainternmed.2020.0403","article-title":"Development and validation of a penicillin allergy clinical decision rule","volume":"180","author":"J A Trubiano","year":"2020","journal-title":"JAMA Intern Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.anai.2020.03.012","article-title":"Children with reported penicillin allergy: Public health impact and safety of delabeling","volume":"124","author":"D Vyles","year":"2020","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0982-8842.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T23:49:15Z","timestamp":1606780155000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0982-8842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":24,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0982-8842","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}