{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:27:23Z","timestamp":1770456443067,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nObjective The aim of this study was to evaluate the importance of growth-differentiation factor-15 level and tissue Doppler imaging in the detection of cardiomyopathy in children who have type 1 diabetes mellitus.<\/jats:p><jats:p>\nMaterials and Methods Thirty-eight patients (11 males and 27 females) with type 1 diabetes mellitus were included in this study. The control group consisted of 40 age- and gender-matched healthy volunteers. All children underwent a detailed echocardiography, which contained an m-mode, pulse Doppler and tissue Doppler imaging; and growth-differentiation factor-15 level was measured.<\/jats:p><jats:p>\nResults In this study, there were significant differences between diastolic function parameters of the heart. The mitral isovolumic contraction time, contraction time, and isovolumic relaxation time values were different in the patients than in the controls (p&lt;0.01, p&lt;0.01, p&lt;0.01, respectively). Also, the tricuspid isovolumic contraction time, contraction time, and isovolumic relaxation time values were different in the patients than in the controls (p&lt;0.01, p=0.01, p&lt;0.01, respectively). No statistically significant difference was found between the other M-mode parameters. Mean plasma growth-differentiation factor-15 level was significantly higher in patients than in healthy controls (p&lt;0.01).<\/jats:p><jats:p>\nConclusion The follow-up of children with type 1 diabetes mellitus in terms of cardiomyopathy and the use of tissue Doppler imaging and growth differentiation factor-15 levels may be useful.<\/jats:p>","DOI":"10.1055\/a-0983-1673","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T23:01:00Z","timestamp":1566255660000},"page":"574-580","source":"Crossref","is-referenced-by-count":4,"title":["Growth Differentiation Factor-15 Level and Tissue Doppler Echocardiography as a Tool in Identification of Cardiac Effects in the Children with Type 1 Diabetes Mellitus"],"prefix":"10.1055","volume":"129","author":[{"given":"Celil","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Patnos State Hospital, Agri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muammer","family":"Buyukinan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Konya Training and Research Hospital, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz Turgut","family":"Gederet","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Konya Training and Research Hospital, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husamettin","family":"Vatansev","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Selcuk University Medical Faculty, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Samet","family":"Ozcelik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. Ali Kemal Belviranli Obstetrics and Gynecology Hospital, Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"ref1","first-page":"436","volume-title":"Diabetes Mellitus Clinical Pediatric Endocrinology 5th Edition, Massachusetts (USA)","author":"A W Norris","year":"2005"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jdiacomp.2018.05.007","article-title":"What are the clinical, quality-of-life, and cost consequences of 30\u202fyears of excellent vs. poor glycemic control in type 1 diabetes?","volume":"32","author":"W H Herman","year":"2018","journal-title":"J Diabetes Complications"},{"key":"ref3","first-page":"231","article-title":"Echocardiographic assessment of ventricular function in young patients with asthma","volume":"110","author":"C R De-Paula","year":"2018","journal-title":"Arq Bras Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.healun.2016.11.007","article-title":"Cardiac dysfunction in children and young adults with heart transplantation: a comprehensive echocardiography study","volume":"36","author":"M Chinali","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.RES.0000207919.83894.9d","article-title":"GDF15, a cardioprotective TGF-beta superfamily protein","volume":"98","author":"T Ago","year":"2006","journal-title":"Circ Res"},{"key":"ref6","first-page":"65","article-title":"Growth-differentiation factor-15: a novel biomarker in patients with diastolic dysfunction?","volume":"97","author":"W Dinh","year":"2011","journal-title":"Arq Bras Cardiol"},{"key":"ref7","first-page":"4","article-title":"International Society for Pediatric and Adolescent Diabetes. 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