{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:00:15Z","timestamp":1792483215071,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is a novel endoscopic procedure designed to facilitate sustained luminal patency in patients with gastric outlet obstruction. The primary aim of this study was to evaluate the efficacy and safety of EUS-GE for treatment of gastric outlet obstruction.<\/jats:p><jats:p>\n          Methods\u2002Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were performed through April 2019. Patients with benign and malignant gastric outlet obstruction were included. Measured outcomes included: immediate technical and clinical success as well as rate of serious adverse events (AEs). Heterogeneity was assessed with Cochran Q test and I\n          2 statistics. Publication bias was ascertained by funnel plot and Egger regression testing.<\/jats:p><jats:p>\n          Results\u2002A total of five studies (n\u200a=\u200a199 patients; 45.73\u200a% male) were included in this study. Four retrospective studies and one prospective study were analyzed. Mean age of patients that underwent the EUS-GE procedure was 64.52\u200a\u00b1\u200a1.37 years with a pooled mean follow-up period of 4.32\u200a\u00b1\u200a1.65 months. In 21\u200a% of patients (n\u200a=\u200a43), gastric outlet obstruction was due to benign causes. Immediate technical success was 92.90\u200a% (95\u200a% CI; 88.26\u200a\u2013\u200a95.79; I2\u200a=\u200a0.00\u200a%) and reported in all studies. The clinical success rate of EUS-GE was 90.11\u200a% (95\u200a% CI; 84.64\u200a\u2013\u200a93.44; I2\u200a=\u200a0.00\u200a%). Serious AEs occurred in 5.61\u200a% (95\u200a% CI; 2.87\u200a\u2013\u200a10.67; I2\u200a=\u200a1.67\u200a%) of cases and were related to peritonitis, perforation, bleeding, and abdominal pain. Re-intervention rate was 11.43\u200a% (95\u200a% CI; 7.29\u200a\u2013\u200a17.46; I2\u200a=\u200a17.38\u200a%).<\/jats:p><jats:p>\n          Conclusions\u2002EUS-GE appears to provide an effective and safe minimally invasive alternative for treatment of benign and malignant gastric outlet obstruction.<\/jats:p>","DOI":"10.1055\/a-0996-8178","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T23:10:46Z","timestamp":1571872246000},"page":"E1474-E1482","source":"Crossref","is-referenced-by-count":96,"title":["Efficacy and safety of EUS-guided gastroenterostomy for benign and malignant gastric outlet obstruction: a systematic review and meta-analysis"],"prefix":"10.1055","volume":"07","author":[{"given":"Thomas R.","family":"McCarty","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women\u2019s Hospital, Boston, Massachusetts, United States"},{"name":"Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Garg","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Cleveland, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women\u2019s Hospital, Boston, Massachusetts, United States"},{"name":"Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Rustagi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, New Mexico, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,23]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0996-8178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T23:10:48Z","timestamp":1571872248000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0996-8178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,10,22]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0996-8178","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]}}}