{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:27:07Z","timestamp":1790177227351,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270925"],"award-info":[{"award-number":["81270925"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Scientific Research Projects of Hunan health and family planning commission","award":["A2017011"],"award-info":[{"award-number":["A2017011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fatty acids induced hepatic inflammation plays an important role in\n                        nonalcoholic fatty liver disease (NAFLD) pathogenesis. Hydrogen sulfide\n                            (H2S), an endogenous gasotransmitter, has been established to\n                        possess potent anti-inflammation in various human organs. However, the\n                        anti-inflammation property of H2S in the fatty liver is still\n                        needed to further elucidate. Hence, this study aimed to investigate whether\n                        exogenous H2S can protect hepatocytes against in\ufb02ammation\n                        induced by palmitic acid (PA). HepG2 hepatocytes were exposed to PA for\n                        24\u2009h to induce free fatty acids-induced inflammation. The cells were\n                        pretreated with NaHS (a donor of  H2S) before exposure to PA. Cell viability,\n                        inflammatory cytokines (TNF-\u03b1, IL-6 and IL-1\u03b2), NLRP3\n                        inflammasome and NF-\u03baB were measured by a combination of MTT assay,\n                        ELISA, Western blot and Immunofluorescence. Here, we found that exogenous\n                            H2S dose-dependently inhibited the expression of\n                        pro-inflammatory cytokines, NLRP3 inflammasome and activation of\n                        NF-\u03baB signaling in PA-induced HepG2 cells. Thus, H2S\n                        might be a candidate therapeutic agent against NAFLD.<\/jats:p>","DOI":"10.1055\/a-0999-0149","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T23:03:18Z","timestamp":1571353398000},"page":"137-143","source":"Crossref","is-referenced-by-count":15,"title":["Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular\n                    Inflammation in HepG2 Cells"],"prefix":"10.1055","volume":"128","author":[{"given":"Ya-Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao-Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Zhen","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Hua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, the First Affiliated\n                    Hospital of University of South China, Hengyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,17]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0999-0149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:50:28Z","timestamp":1583365828000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0999-0149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,3,4]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0999-0149","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]}}}