{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:46:50Z","timestamp":1748324810074},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Significant advancements have been made in recent years in advanced breast cancer and nearly all of them have been in the field of targeted therapy. Pertuzumab and trastuzumab-emtansine (T-DM1) have been able to be introduced in HER2-positive breast cancer. Now other anti-HER2 therapies are being developed (e.g. margetuximab, DS-8201a, pyrotinib) which can overcome other resistance mechanisms in the HER2 signalling pathway. In the field of hormone-receptor-positive breast cancer, an mTOR inhibitor and CDK4\/6 inhibitors were introduced in the past. Now the introduction of the first PI3K inhibitor is forthcoming and this inhibitor will involve genetic testing of the tumour for a mutation in the PIK3CA gene. There are also significant advancements in triple-negative breast cancer: By combining chemotherapy and immunotherapy, an advantage for overall survival was able to be demonstrated in a subgroup (immune cells PD-L1-positive). The PARP inhibitor therapy for HER2-negative patients with a germ line mutation in BRCA1 or BRCA2 was also associated with an improved overall survival in a subgroup. These promising new study results are summarised in this review.<\/jats:p>","DOI":"10.1055\/a-1001-9952","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T22:59:38Z","timestamp":1571785178000},"page":"1090-1099","source":"Crossref","is-referenced-by-count":16,"title":["Update Breast Cancer 2019 Part 5 \u2013 Diagnostic and Therapeutic Challenges of New, Personalised Therapies in Patients with Advanced Breast Cancer"],"prefix":"10.1055","volume":"79","author":[{"given":"Manfred","family":"Welslau","sequence":"additional","affiliation":[{"name":"Onkologie Aschaffenburg, Aschaffenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas D.","family":"Hartkopf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkmar","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"W\u00f6ckel","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Lux","sequence":"additional","affiliation":[{"name":"Kooperatives Brustzentrum Paderborn, Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe Frauenklinik St.\u00a0Louise, Paderborn, St.\u00a0Josefs-Krankenhaus, Salzkotten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Janni","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Ettl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"L\u00fcftner","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University Hospital, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Belleville","sequence":"additional","affiliation":[{"name":"ClinSol GmbH & Co KG, W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Fasching","sequence":"additional","affiliation":[{"name":"Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christian","family":"Kolberg","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiba","family":"Nabieva","sequence":"additional","affiliation":[{"name":"Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Overkamp","sequence":"additional","affiliation":[{"name":"OncoConsult Hamburg GmbH, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin-Andrei","family":"Taran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Y.","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Tesch","sequence":"additional","affiliation":[{"name":"Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja N.","family":"Fehm","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,10,22]]},"container-title":["Geburtshilfe und 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