{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T07:58:50Z","timestamp":1648799930129},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Introduction<\/jats:title><jats:p>Williams-Beuren syndrome (WBS) is characterized by a combination of cardiovascular\n                malformations, typical dysmorphic stigmata, a moderate developmental delay and\n                behavioral abnormalities. According to the literature the incidence is within a\n                range from 1:20\u2009000 to 1:7\u2009500 (Yildiz O et al., World J Pediatr\n                Congenit Heart Surg 2015; 6: 311\u2013316). Microdeletion of chromosome region\n                7q11.23 is pathognomonic, affecting the elastin gene (von Beust G et al., Klin\n                Padiatr 2000; 212: 299\u2013307). Due to reduced elastin content elasticity in\n                the media of the arterial vessel wall is reduced, resulting in a vasculopathy\n                affecting preferentially the medium size and large arteries. As a characteristic\n                feature supravalvular aortic and pulmonary artery stenosis is very common in\n                patients with WBS. The supravalvular aortic stenosis may also affect the origin of\n                the coronary arteries resulting in an increased risk of myocardial ischemia (Collins\n                RT 2nd, Circulation 2013; 127: 2125\u20132134). We report the case of\n                a little boy with ischemic mitral regurgitation due to stenosis of the left main\n                coronary artery.<\/jats:p>","DOI":"10.1055\/a-1007-8700","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T20:57:01Z","timestamp":1572382621000},"page":"40-42","source":"Crossref","is-referenced-by-count":0,"title":["Severe Mitral Valve Regurgitation due to Significant Coronary Artery\n                    Stenosis in a 14-month-old boy with Williams-Beuren Syndrome"],"prefix":"10.1055","volume":"232","author":[{"given":"Andreas","family":"Hornung","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Sieverding","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlensak","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hofbeck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,10,29]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1007-8700.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T19:14:06Z","timestamp":1579547646000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1007-8700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,8]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1007-8700","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]}}}