{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:11:16Z","timestamp":1775481076067,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"DDG (Deutsche Diabetes\n                        Gesellschaft) to N.P."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Background The single nucleotide polymorphism in TCF7L2 rs7903146 is\n                    associated with an increased risk of type 2 diabetes mellitus and gestational\n                    diabetes mellitus. Mechanisms by which this mutation acts, and its impact on the\n                    clinical course of the diseases remain unclear. Here we investigated the\n                    clinical impact of the T risk allele in women with gestational diabetes\n                    mellitus.<\/jats:p><jats:p>\n                    Methods We genotyped the C\/T polymorphism in 164 Caucasian women\n                    with GDM (German n=114; Greek n=50). The impact of the T allele\n                    on the results of the 75g oral-glucose-tolerance-test, and on the required\n                    therapy (diet\/lifestyle or insulin) was investigated.<\/jats:p><jats:p>\n                    Results During oral-glucose-tolerance-test, women harboring the T allele\n                    displayed significantly higher glucose values at 60 min (p=0.034) and\n                    were more likely to require insulin therapy even after adjusting for\n                    confounders, such as BMI and age.<\/jats:p><jats:p>\n                    Conclusion These results provide evidence that the T risk allele in\n                    TCF7L2 rs7903146 is associated with failure in early postprandial glycemic\n                    control and requirement of insulin therapy in women with gestational diabetes\n                    mellitus, even after adjusting for confounding factors such BMI and age.<\/jats:p>","DOI":"10.1055\/a-1008-9223","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T23:16:30Z","timestamp":1569280590000},"page":"663-666","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Impact of the TCF7L2 Gene rs7903146 Type 2 Diabetes\n                    Mellitus Risk Polymorphism in Women with Gestational Diabetes Mellitus: Impaired\n                    Glycemic Control and Increased Need of Insulin Therapy"],"prefix":"10.1055","volume":"128","author":[{"given":"Laura","family":"Potasso","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II,\n                    Medical Center \u2013 University of Freiburg, Faculty of Medicine, University\n                    of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Perakakis","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II,\n                    Medical Center \u2013 University of Freiburg, Faculty of Medicine, University\n                    of Freiburg, Freiburg, Germany"},{"name":"Current address: Division of Endocrinology, Diabetes and Metabolism,\n                    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston,\n                    Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolia","family":"Lamprinou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Freiburg, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Centre Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Freiburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elektra","family":"Polyzou","sequence":"additional","affiliation":[{"name":"University Hospital Attikon, 3rd Department of Obstetrics and\n                    Gynecology, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kassanos","sequence":"additional","affiliation":[{"name":"University Hospital Attikon, 3rd Department of Obstetrics and\n                    Gynecology, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Freiburg, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Centre Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg, Freiburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"P\u00e4th","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II,\n                    Medical Center \u2013 University of Freiburg, Faculty of Medicine, University\n                    of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II,\n                    Medical Center \u2013 University of Freiburg, Faculty of Medicine, University\n                    of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Laubner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Medicine II,\n                    Medical Center \u2013 University of Freiburg, Faculty of Medicine, University\n                    of Freiburg, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.2337\/dc07-S042","article-title":"Diagnosis and classification of diabetes mellitus","volume":"30","author":"American Diabetes A","year":"2007","journal-title":"Diabetes Care"},{"key":"ref2","first-page":"B161","article-title":"Summary and recommendations of the Fourth International Workshop-Conference on\n                    Gestational Diabetes Mellitus","volume":"21","author":"B E 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