{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:36:04Z","timestamp":1758274564121},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2002The prevalence of alveolar echinococcosis (AE) and cystic echinococcosis (CE) in Germany is increasing. The number of cases in northern and eastern regions is low, so there is little experience with regard to diagnosis and therapy.<\/jats:p><jats:p>\n          Objectives\u2002The objective of this paper was to evaluate the management of suspected and\/or diagnosed echinococcosis at a university center in a low-prevalence region.<\/jats:p><jats:p>\n          Methods\u2002All the patients at the Leipzig University Hospital between 2004 and 2018 who had been serologically examined for echinococci were included in a retrospective cohort study. Clinical course, imaging, histology, therapeutic characteristics, relevant comorbidities and risk factors for AE and CE were evaluated. A time-staggered prevalence estimation, as well as sensitivity and specificity calculations for the serological tests, were performed.<\/jats:p><jats:p>\n          Results\u2002A total of 382 patients were enrolled, with 11 AE and 7\u200aCE cases identified. The mean prevalence rate of AE in this cohort was 2.9\u200a% and that of CE was 1.8\u200a%. Among the patients, 56\u200a% had known risk factors for AE and CE. The serological tests showed a sensitivity of 86\u200a% and a specificity of 91\u200a%. Two patients with false-negative serology were diagnosed by biopsy. All CE and 5 AE patients (45\u200a%) were operated on. Six AE patients received long-term treatment with albendazole.<\/jats:p><jats:p>\n          Conclusions\u2002AE and CE are rare diseases in the greater Leipzig region; however, case numbers are on the rise. Due to favorable factors such as the escalation of migration, a further increase is expected. Diagnosis and therapy are challenging and should be supported by specialists (experienced infectiologists, imaging experts and skilled hepatobiliary surgeons) who should be integrated in a German network.<\/jats:p>","DOI":"10.1055\/a-1013-4405","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T18:44:18Z","timestamp":1574102658000},"page":"1281-1290","source":"Crossref","is-referenced-by-count":5,"title":["Frequency and clinical presentation of alveolar and cystic echinococcosis in a tertiary medical center in Germany 2004\u20132018: lessons from a low-prevalence area"],"prefix":"10.1055","volume":"57","author":[{"given":"Thomas","family":"Karlas","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Department of Gastroenterology, Hepatology, Infectious Diseases, Pneumology, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Division of Infectious Diseases and Tropical Medicine, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Blank","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Department of Gastroenterology, Hepatology, Infectious Diseases, Pneumology, Germany"},{"name":"University of Leipzig, Faculty of Medicine, Integrated Research and Treatment Center Adiposity Diseases Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Lippmann","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Germany"},{"name":"Leipzig University Hospital, Interdisciplinary Center for Infectious Diseases, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Seehofer","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Division of Hepatobiliar and Transplant Surgery, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"L\u00fcbbert","sequence":"additional","affiliation":[{"name":"Leipzig University Hospital, Department of Gastroenterology, Hepatology, Infectious Diseases, Pneumology, Germany"},{"name":"Leipzig University Hospital, Division of Infectious Diseases and Tropical Medicine, Germany"},{"name":"Leipzig University Hospital, Interdisciplinary Center for Infectious Diseases, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,11,18]]},"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1013-4405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T18:44:28Z","timestamp":1574102668000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1013-4405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,18]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1013-4405","relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"value":"0044-2771","type":"print"},{"value":"1439-7803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}