{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:29:06Z","timestamp":1787563746384,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Commiphora gileadensis, locally known as becham, is a plant used in traditional Arabian medicine for treating headache, constipation, stomach, joint pain, and inflammatory disorders. Several studies have reported its antibacterial properties; however, no study has demonstrated its antiviral activity. This study aimed to evaluate the antiviral activity of C. gileadensis as well as to isolate its active compound and investigate its mode of action. This activity was evaluated using 4 viruses, herpes simplex virus type 2 (HSV-2), respiratory syncytial virus type B (RSV-B), coxsackie virus B type 3, and adenovirus type 5 by performing the plaque reduction assay and the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays for enveloped and nonenveloped viruses, respectively. The methanol extract of C. gileadensis leaves only showed antiviral activity against enveloped viruses with a selectivity index of 11.19 and 10.25 for HSV-2 and RSV-B, respectively. The study of the mechanism underlying antiviral activity demonstrated a virucidal effect by direct contact with these target viruses. The active compound, isolated using bio-guided assays involving TLC, was identified as guggulsterone by HPLC-diode array detection coupled with electrospray ionization mass spectrometry. Guggulsterone is an antagonist of the bile acid receptor and a modulator of cholesterol metabolism; however, its antimicrobial properties have been reported for the first time in this study.<\/jats:p>","DOI":"10.1055\/a-1014-3303","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T19:14:07Z","timestamp":1570475647000},"page":"1225-1232","source":"Crossref","is-referenced-by-count":24,"title":["Virucidal Effect of Guggulsterone Isolated from Commiphora gileadensis"],"prefix":"10.1055","volume":"85","author":[{"given":"Lamjed","family":"Bouslama","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Substances, Center of Biotechnology of Borj Cedria, University of Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochra","family":"Kouidhi","sequence":"additional","affiliation":[{"name":"Medical Laboratory Department, College of Applied Medical Sciences, Yanbu, Taibah University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir Mohammed","family":"Alqurashi","sequence":"additional","affiliation":[{"name":"Medical Laboratory Department, College of Applied Medical Sciences, Yanbu, Taibah University, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Chaieb","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Laboratory of Analysis, Treatment and valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Monastir University, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Papetti","sequence":"additional","affiliation":[{"name":"Nutraceutical & Food Chemical-Toxicological Analysis Laboratory, Department of Drug Sciences, University of Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,7]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1014-3303.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T19:31:14Z","timestamp":1572377474000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1014-3303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":0,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2019,10,29]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1014-3303","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,7]]}}}