{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:30:20Z","timestamp":1788910220240,"version":"build-2803163510"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Objective To investigate the association between serum C-peptide\n                        level and cardiovascular autonomic neuropathy (CAN) in individuals with type\n                        2 diabetes mellitus (DM) according to estimated glomerular filtration rate\n                        (eGFR)<\/jats:p><jats:p>\n                        Methods In a cross-sectional study, we examined 939 individuals with\n                        type 2 DM. We measured fasting C-peptide, 2-hour postprandial C-peptide, and\n                        \u0394C-peptide (postprandial C-peptide minus fasting C-peptide) levels.\n                        The individuals were classified into 2 groups based on eGFR: individuals\n                        without impaired renal function (eGFR\n                            \u226560\u2009ml\u2219min\u22121\n                            1.73m\u22122) and those with impaired renal function (eGFR\n                            &lt;60\u2009ml\u2219min\u22121\n                            1.73m\u22122).<\/jats:p><jats:p>\n                        Results Individuals with CAN had lower fasting C-peptide,\n                        postprandial C-peptide, and \u0394C-peptide levels in patients both with\n                        and without impaired renal function. Multivariate logistic regression\n                        analyses adjusted for gender, age, and other confounders, including eGFR,\n                        showed that serum C-peptide level was significantly associated with CAN\n                        (odds ratio [OR] per standard deviation increase in the log-transformed\n                        value, 0.67; 95% confidence interval [CI], 0.52\u20130.87 for\n                        fasting C-peptide, P &lt; 0.01; OR, 0.62; 95% CI,\n                        0.47\u20130.83 for postprandial C-peptide, P &lt; 0.01; OR, 0.71;\n                        95% CI, 0.54\u20130.93 for \u0394C-peptide, P &lt;\n                        0.05).<\/jats:p><jats:p>\n                        Conclusions Serum C-peptide level was negatively associated with CAN\n                        in individuals with type 2 DM independent of eGFR.<\/jats:p>","DOI":"10.1055\/a-1017-3048","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T23:04:09Z","timestamp":1571094249000},"page":"607-614","source":"Crossref","is-referenced-by-count":7,"title":["Association Between Serum C-Peptide Level and Cardiovascular\n                    Autonomic Neuropathy According to Estimated Glomerular Filtration Rate in\n                    Individuals with Type 2 Diabetes"],"prefix":"10.1055","volume":"128","author":[{"given":"Jin Ook","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal\n                    Medicine, Chonnam National University Medical School, Republic of\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal\n                    Medicine, Chonnam National University Medical School, Republic of\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyeok","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal\n                    Medicine, Chonnam National University Medical School, Republic of\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal\n                    Medicine, Chonnam National University Medical School, Republic of\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal\n                    Medicine, Chonnam National University Medical School, Republic of\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic neuropathy: A position statement by the American Diabetes\n                    Association","volume":"40","author":"R Pop-Busui","year":"2017","journal-title":"Diabetes Care"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/dc09-1294","article-title":"Cardiac autonomic neuropathy in diabetes: A clinical perspective","volume":"33","author":"R Pop-Busui","year":"2010","journal-title":"Diabetes Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/dme.12159","article-title":"The clinical utility of C-peptide measurement in the care of patients with\n                    diabetes","volume":"30","author":"A G 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1017-3048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T22:44:10Z","timestamp":1599173050000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1017-3048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,14]]},"references-count":32,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,9,3]]},"published-print":{"date-parts":[[2020,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1017-3048","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,14]]}}}