{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T01:44:20Z","timestamp":1648604660164},"reference-count":100,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Neugeborene sind mit einer Reihe nat\u00fcrlicher Anpassungsmechanismen ausgestattet, die sie trotz ihres (k\u00f6rpergr\u00f6\u00dfenabh\u00e4ngig) hohen Energiebedarfs vor Mangelversorgung sch\u00fctzen. Hierzu geh\u00f6rt der aus einer bradykarden Kreislaufzentralisation mit begleitender Apnoe bestehende, von wasserlebenden S\u00e4ugetieren bekannte Tauchreflex, der einen sparsamen Umgang mit den O2-Reserven gew\u00e4hrleistet und sich in einer nachlaufenden Laktateinschwemmung aus der K\u00f6rperperipherie \u00e4u\u00dfert. Metabolisch verhalten sich S\u00e4ugetierfeten \u201ewie ein Organ der Mutter\u201c und zeigen damit eine Winterschlaf-artige Abweichung von der \u00fcblichen K\u00f6rpergr\u00f6\u00dfe-Energieumsatz-Beziehung, durch die sie an das limitierte intrauterine O2-\/Substratangebot angepasst sind. Im Falle einer Mangelversorgung k\u00f6nnen sie ihren Energiebedarf weiter drosseln, indem sie auf Wachstum verzichten, wobei der Plazenta eine Gatekeeper-Funktion zukommt. Ein postnataler O2-Mangel hat nicht nur eine Suppression der zitterfreien Thermogenese, sondern auch einen hypoxischen Hypometabolismus zur Folge, wie er sonst nur von poikilothermen Tierarten bekannt ist. Nach prolongierter Apnoe setzen Schnappatemz\u00fcge ein, die durch kurze pO2-Anstiege eine rudiment\u00e4re Herzaktion aufrechterhalten (Selbstwiederbelebung). Insgesamt verz\u00f6gern diese Mechanismen ein kritisches O2-Defizit und bedingen so eher eine \u201eResistenz\u201c als eine \u201eToleranz\u201c gegen\u00fcber einer Hypoxie. Da sie auf einer (aktiven) Drosselung des Energiebedarfs beruhen, sind sie nicht leicht von dem (passiven) Zusammenbruch des Stoffwechsels aufgrund einer Hypoxie zu unterscheiden.<\/jats:p>","DOI":"10.1055\/a-1019-6007","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T20:19:46Z","timestamp":1608149986000},"page":"203-215","source":"Crossref","is-referenced-by-count":0,"title":["Den Mangel \u00fcberleben: Nat\u00fcrliche Anpassungen bei Neugeborenen"],"prefix":"10.1055","volume":"225","author":[{"given":"Dominique","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-2002-33168","article-title":"Phylogenese des Stoffwechsels der S\u00e4ugetiere","volume":"37","author":"D Singer","year":"2002","journal-title":"An\u00e4sthesiol Intensivmed Notfallmed Schmerzther"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-25155-9","volume-title":"Vergleichende Tierphysiologie","author":"G Heldmaier","year":"2013"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1126\/science.139.3554.492","article-title":"Anoxia: tolerance in reptiles","volume":"139","author":"D A Belkin","year":"1963","journal-title":"Science"},{"key":"ref4","first-page":"R1083","article-title":"Turtles and rats: a biochemical comparison of anoxia-tolerant and anoxia-sensitive brains","volume":"257","author":"R K Suarez","year":"1989","journal-title":"Am J Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1086\/422767","article-title":"The evolution of endothermy: role for membranes and molecular activity","volume":"77","author":"P L Else","year":"2004","journal-title":"Physiol Biochem Zool"},{"key":"ref6","volume-title":"The fire of life: An introduction to animal energetics","author":"M Kleiber","year":"1961"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139167826","volume-title":"Scaling: Why is animal size so important?","author":"K Schmidt-Nielsen","year":"1984"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.resp.2004.02.009","article-title":"Metabolic adaptation to hypoxia: cost and benefit of being small","volume":"141","author":"D Singer","year":"2004","journal-title":"Respir Physiol Neurobiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tca.2006.05.006","article-title":"Metabolic size relationship: oxygen availability as the \u201cmissing link\u201d between structure and function?","volume":"446","author":"D Singer","year":"2006","journal-title":"Thermochim Acta"},{"key":"ref10","first-page":"33","volume-title":"Physiologie der Atmung im Kindesalter","author":"D Singer","year":"2017"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-79934-1","volume-title":"Thermoregulation of sick and low birth weight neonates","author":"A Okken","year":"1995"},{"key":"ref12","first-page":"502","volume-title":"The thermal environment of the intensive care nursery","author":"J Agren","year":"2015","edition":"10th ed."},{"key":"ref13","first-page":"570","volume-title":"W\u00e4rmehaushalt und Temperaturregulation","author":"M Gekle","year":"2019","edition":"9. Aufl."},{"key":"ref14","first-page":"95","volume-title":"What is the right temperature for a neonate?","author":"D Singer","year":"2020"},{"key":"ref15","first-page":"327","article-title":"Tolerance of the newborn to hypoxia and anoxia","volume":"133","author":"H E Himwich","year":"1941","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0305-0491(95)02046-2","article-title":"Anoxia tolerant animals from a neurobiological perspective","volume":"113","author":"P L Lutz","year":"1996","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1095-6433(99)00057-4","article-title":"Neonatal tolerance to hypoxia: a comparative-physiological approach","volume":"123","author":"D Singer","year":"1999","journal-title":"Comp Biochem Physiol A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0034-5687(99)00038-9","article-title":"How newborn mammals cope with hypoxia","volume":"116","author":"J P Mortola","year":"1999","journal-title":"Respir Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1242\/jeb.085381","article-title":"No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates","volume":"217","author":"J Larson","year":"2014","journal-title":"J Exp Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/apha.12747","article-title":"Hypometabolism as the ultimate defence in stress response: how the comparative approach helps understanding of medically relevant questions","volume":"219","author":"T A Gorr","year":"2017","journal-title":"Acta Physiol"},{"key":"ref21","first-page":"121","volume-title":"Physiologie des Feten","author":"D Singer","year":"2018"},{"key":"ref22","first-page":"29","volume-title":"Perinatale Asphyxie \u2013 ein gleitendes Kontinuum","author":"D Singer","year":"2017","edition":"5. Aufl."},{"key":"ref23","first-page":"1","article-title":"Diving and asphyxia. A comparative study of animals and man","volume":"40","author":"R Elsner","year":"1983","journal-title":"Monogr Physiol Soc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/physrev.1997.77.3.837","article-title":"Physiology of diving of birds and mammals","volume":"77","author":"P J Butler","year":"1997","journal-title":"Physiol Rev"},{"key":"ref25","volume-title":"Animal physiology","author":"R W Hill","year":"2004"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1152\/physiol.00020.2013","article-title":"The mammalian diving response: an enigmatic reflex to preserve life?","volume":"28","author":"W M Panneton","year":"2013","journal-title":"Physiology"},{"key":"ref27","first-page":"181","article-title":"Fetal circulatory responses to oxygen lack","volume":"16","author":"A Jensen","year":"1991","journal-title":"J Dev Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0301-2115(98)00325-X","article-title":"Dynamics of fetal circulatory responses to hypoxia and asphyxia","volume":"84","author":"A Jensen","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1113\/JP272999","article-title":"Sex, drugs and rock and roll: tales from preterm fetal life","volume":"595","author":"L Bennet","year":"2017","journal-title":"J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajog.2019.07.032","article-title":"The physiology of intrapartum fetal compromise at term","volume":"222","author":"J M Turner","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/scientificamerican1263-92","article-title":"The master switch of life","volume":"209","author":"P F Scholander","year":"1963","journal-title":"Sci Am"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1056\/NEJM200102153440701","article-title":"The continuing value of the Apgar score for the assessment of newborn infants","volume":"344","author":"B M Casey","year":"2001","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fneur.2018.00293","article-title":"Cerebral lactate concentration in neonatal hypoxic-ischemic encephalopathy: in relation to time, characteristic of injury, and serum lactate concentration","volume":"9","author":"T W Wu","year":"2018","journal-title":"Front Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0040-6031(02)00254-X","article-title":"Oxygen supply, body size, and metabolic rate at the beginning of mammalian life","volume":"394","author":"D Singer","year":"2002","journal-title":"Thermochim Acta"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cbpa.2007.05.004","article-title":"Perinatal adaptation in mammals: the impact of metabolic rate","volume":"148","author":"D Singer","year":"2007","journal-title":"Comp Biochem Physiol A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1748-1716.1900.tb00299.x","article-title":"\u00dcber den respiratorischen Stoffwechsel des H\u00fchnerembryos","volume":"10","author":"A K Hasselbalch","year":"1900","journal-title":"Skand Arch Physiol"},{"key":"ref37","first-page":"193","volume-title":"Adult and embryonic metabolism in birds and the role of shell conductance","author":"C V Paganelli","year":"1984"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1748-1716.1900.tb00301.x","article-title":"Der respiratorische Stoffwechsel des S\u00e4ugethierembryos","volume":"10","author":"C Bohr","year":"1900","journal-title":"Skand Arch Physiol"},{"key":"ref39","first-page":"124","volume-title":"Comparison of embryonic development in birds and mammals: birth weight, time, and cost","author":"H Rahn","year":"1982"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.1959.sp006194","article-title":"The increase in oxygen consumption of the lamb after birth","volume":"146","author":"G S Dawes","year":"1959","journal-title":"J Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1113\/expphysiol.1997.sp004035","article-title":"Engine and radiator: fetal and placental interactions for heat dissipation","volume":"82","author":"H J Schr\u00f6der","year":"1997","journal-title":"Exp Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1016\/j.placenta.2012.06.006","article-title":"Oxygen delivery and fetal-placental growth: beyond a question of supply and demand?","volume":"33","author":"A J Murray","year":"2012","journal-title":"Placenta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1113\/jphysiol.2008.163634","article-title":"Where the O2 goes to: preservation of human fetal oxygen delivery and consumption at high altitude","volume":"587","author":"L Postigo","year":"2009","journal-title":"J Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1113\/jphysiol.1965.sp007701","article-title":"Heat balance and the metabolic rate of new-born babies in relation to environmental temperature; and the effect of age and of weight on basal metabolic rate","volume":"180","author":"J R Hill","year":"1965","journal-title":"J Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0034-5687(84)90112-9","article-title":"A distinction must be made between the ontogeny and the phylogeny of metabolism in order to understand the mass exponent of energy metabolism","volume":"55","author":"W Wieser","year":"1984","journal-title":"Respir Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0040-6031(97)00427-9","article-title":"Thermometry and calorimetry in the neonate: recent advances in monitoring and research","volume":"309","author":"D Singer","year":"1998","journal-title":"Thermochim Acta"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1067\/mpd.2003.143","article-title":"Longitudinal study of energy expenditure in preterm neonates <30 weeks\u2019 gestation during the first three postnatal weeks","volume":"142","author":"K Bauer","year":"2003","journal-title":"J Pediatr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1079\/BJN2002816","article-title":"Longitudinal evaluation of energy expenditure in preterm infants with birth weight less than 1000 g","volume":"89","author":"J Bauer","year":"2003","journal-title":"Br J Nutr"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3945\/ajcn.2009.28304","article-title":"Metabolic rate analysis of healthy preterm and full-term infants during the first weeks of life","volume":"90","author":"J Bauer","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.fertnstert.2009.08.002","article-title":"Embryonic heart rates","volume":"92","author":"T J DuBose","year":"2009","journal-title":"Fertil Steril"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/412080","article-title":"Body size, physiological time, and longevity of homeothermic animals","volume":"56","author":"S L Lindstedt","year":"1981","journal-title":"Quart Rev Biol"},{"key":"ref52","volume-title":"The physiology of natural hibernation","author":"C Kaiser","year":"1961"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00692726","article-title":"Reduction of metabolism during hibernation and daily torpor in mammals and birds: temperature effect or physiological inhibition?","volume":"158 B","author":"F Geiser","year":"1988","journal-title":"J Comp Physiol"},{"key":"ref54","first-page":"447","volume-title":"Metabolic size allometry and the limits to beneficial metabolic reduction: hypothesis of a uniform specific minimal metabolic rate","author":"D Singer","year":"1993"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.resp.2004.03.014","article-title":"Natural hypometabolism during hibernation and daily torpor in mammals","volume":"141","author":"G Heldmaier","year":"2004","journal-title":"Respir Physiol Neurobiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0300-9629(81)90645-9","article-title":"Mammalian hibernation and the oxygen consumption of a denning black bear (Ursus americanus)","volume":"69","author":"P D Watts","year":"1981","journal-title":"Comp Biochem Physiol A"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1199435","article-title":"Hibernation in black bears: independence of metabolic suppression from body temperature","volume":"331","author":"\u00d8 T\u00f8ien","year":"2011","journal-title":"Science"},{"key":"ref58","first-page":"307","article-title":"Oxygen tensions in developing embryos: system inefficiency or system requirement?","volume":"40","author":"A Ar","year":"1994","journal-title":"Israel J Zool"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000454917","article-title":"Hyperoxia and the immature brain","volume":"38","author":"B Reich","year":"2016","journal-title":"Dev Neurosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tca.2004.08.005","article-title":"Body size effects on tissue metabolic rate and ischemia tolerance in neonatal rat and mouse hearts","volume":"422","author":"D Singer","year":"2004","journal-title":"Thermochim Acta"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1469-7580.2007.00849.x","article-title":"Postnatal lung and metabolic development in two marsupial and four eutherian species","volume":"212","author":"K Szdzuy","year":"2008","journal-title":"J Anat"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1053\/plac.1999.0513","article-title":"Placental oxygen consumption. Part I: in vivo studies \u2013 a review","volume":"21","author":"A M Carter","year":"2000","journal-title":"Placenta"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/9781444393927.ch7","volume-title":"Placental metabolism","author":"N P Illsley","year":"2011"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1079\/PHN2001145","article-title":"Fetal programming and adult health","volume":"4","author":"K M Godfrey","year":"2001","journal-title":"Public Health Nutr"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-physiol-020911-153245","article-title":"Fetal programming and metabolic syndrome","volume":"74","author":"P Rinaudo","year":"2012","journal-title":"Annu Rev Physiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.maturitas.2011.06.017","article-title":"Hungry in the womb: what are the consequences? Lessons from the Dutch famine","volume":"70","author":"T J Roseboom","year":"2011","journal-title":"Maturitas"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4939-1031-1_13","article-title":"Altitude, attitude and adaptation","volume":"814","author":"D A Myers","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMoa067187","article-title":"Glucose regulation in young adults with very low birth weight","volume":"356","author":"P Hovi","year":"2007","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s11892-012-0360-x","article-title":"Maternal\/fetal determinants of insulin resistance in women during pregnancy and in offspring over life","volume":"13","author":"M Lacroix","year":"2013","journal-title":"Curr Diab Rep"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"288.e1","DOI":"10.1016\/j.ajog.2014.05.008","article-title":"The role of brain sparing in the prediction of adverse outcomes in intrauterine growth restriction: results of the multicenter PORTO study","volume":"211","author":"K Flood","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000438451","article-title":"Brain-sparing in intrauterine growth restriction: considerations for the neonatologist","volume":"108","author":"E Cohen","year":"2015","journal-title":"Neonatology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.resp.2004.01.011","article-title":"Implications of hypoxic hypometabolism during mammalian ontogenesis","volume":"141","author":"J P Mortola","year":"2004","journal-title":"Respir Physiol Neurobiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF00691146","article-title":"pH-temperature interactions on protein function and hibernation: GDP binding to brown adipose tissue mitochondria","volume":"158","author":"A Malan","year":"1988","journal-title":"J Comp Physiol B"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000369119","article-title":"Innate hypothermia after hypoxic ischaemic delivery","volume":"107","author":"D Jayasinghe","year":"2015","journal-title":"Neonatology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1152\/jappl.1998.84.3.761","article-title":"Invited editorial on \u201cOxygen transport in conscious newborn dogs during hypoxic hypometabolism\u201d","volume":"84","author":"H Gautier","year":"1998","journal-title":"J Appl Physiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/jappl.1998.84.3.763","article-title":"Oxygen transport in conscious newborn dogs during hypoxic hypometabolism","volume":"84","author":"C V Rohlicek","year":"1998","journal-title":"J Appl Physiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0034-5687(88)90127-2","article-title":"Metabolic and ventilatory rates in newborn kittens during acute hypoxia","volume":"73","author":"J P Mortola","year":"1988","journal-title":"Respir Physiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0034-5687(91)90043-I","article-title":"Metabolism during normoxia, hypoxia and recovery in the newborn kitten","volume":"86","author":"P Frappell","year":"1991","journal-title":"Respir Physiol"},{"key":"ref79","first-page":"H674","article-title":"Developmental changes in oxygenation and circulatory responses to hypoxemia in lambs","volume":"245","author":"D Sidi","year":"1983","journal-title":"Am J Physiol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1203\/00006450-198909000-00003","article-title":"Response to low cardiac output: developmental differences in metabolism during oxygen deficit and recovery in lambs","volume":"26","author":"J T Fahey","year":"1989","journal-title":"Pediatr Res"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1096-4959(01)00311-6","article-title":"Oxyconformity in the intertidal worm Sipunculus nudus: the mitochondrial background and energetic consequences","volume":"129","author":"T Buchner","year":"2001","journal-title":"Comp Biochem Physiol B"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/jeb.200.2.387","article-title":"Hypometabolic homeostasis in overwintering aquatic amphibians","volume":"200","author":"R G Boutilier","year":"1997","journal-title":"J Exp Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.resp.2005.05.006","article-title":"Protective responses of the newborn to hypoxia","volume":"149","author":"J E Fewell","year":"2005","journal-title":"Respir Physiol Neurobiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1152\/ajpregu.2000.279.1.R39","article-title":"Postnatal age influences the ability of rats to autoresuscitate from hypoxic-induced apnea","volume":"279","author":"J E Fewell","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1152\/jappl.1999.87.4.1346","article-title":"Influence of core temperature on autoresuscitation during repeated exposure to hypoxia in normal rat pups","volume":"87","author":"C Serdarevich","year":"1999","journal-title":"J Appl Physiol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1152\/japplphysiol.00003.2013","article-title":"Time- and age-dependent effects of serotonin on gasping and autoresuscitation in neonatal mice","volume":"114","author":"J Chen","year":"2013","journal-title":"J Appl Physiol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"113162","DOI":"10.1016\/j.expneurol.2019.113162","article-title":"Central serotonin and autoresuscitation capability in mammalian neonates","volume":"326","author":"J T Erickson","year":"2020","journal-title":"Exp Neurol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1152\/jappl.1992.73.2.749","article-title":"Autoresuscitation: a survival mechanism in piglets","volume":"73","author":"U M Sanocka","year":"1992","journal-title":"J Appl Physiol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1203\/01.pdr.0000228333.11132.fa","article-title":"Preterminal gasping during hypoxic cardiac arrest increases cardiac function in immature rats","volume":"60","author":"M D Manole","year":"2006","journal-title":"Pediatr Res"},{"key":"ref90","doi-asserted-by":"crossref","DOI":"10.1002\/9781118369784","volume-title":"Advanced paediatric life support: the practical approach","author":"M Samuels","year":"2011","edition":"5th"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0002-9149(83)80096-4","article-title":"Terminal cardiac electrical activity in pediatric patients","volume":"51","author":"C K Walsh","year":"1983","journal-title":"Am J Cardiol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/ana.410010604","article-title":"Cerebral metabolism in newborn dogs during reversible asphyxia","volume":"1","author":"R C Vannucci","year":"1977","journal-title":"Ann Neurol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1152\/physrev.1985.65.2.357","article-title":"Metabolism during fetal life: a functional assessment of metabolic development","volume":"65","author":"C T Jones","year":"1985","journal-title":"Physiol Rev"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-444-64029-1.00010-2","article-title":"Neonatal encephalopathy and hypoxic-ischemic encephalopathy","volume":"162","author":"A J Gunn","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"ref95","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"S E Jacobs","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11910-019-0916-0","article-title":"Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy","volume":"19","author":"G Wassink","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ana.22518","article-title":"Stem cell therapy for neonatal brain injury: perspectives and challenges","volume":"70","author":"L Titomanlio","year":"2011","journal-title":"Ann Neurol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"e0189895","DOI":"10.1371\/journal.pone.0189895","article-title":"Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: a systematic review and meta-analysis of preclinical studies","volume":"12","author":"J Archambault","year":"2017","journal-title":"PLoS One"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"F541","DOI":"10.1136\/archdischild-2014-306284","article-title":"New horizons for newborn brain protection: enhancing endogenous neuroprotection","volume":"100","author":"K J Hassell","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.2741\/4700","article-title":"Perinatal brain injury: mechanisms and therapeutic approaches","volume":"23","author":"J O Davidson","year":"2018","journal-title":"Front Biosci"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1019-6007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T22:36:34Z","timestamp":1624487794000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1019-6007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,7]]},"references-count":100,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,6,23]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1019-6007","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,7]]}}}