{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:57:44Z","timestamp":1767916664821,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Opuntia ficus-indica extract has been used in traditional folk medicine for several purposes and exhibits anti-inflammatory properties. This study was directed to explore the prophylactic effect of O. ficus-indica fruit peel extract against irradiation-induced colitis in rats. GC\/MS analysis of the petroleum ether extract led to recognition of 33 compounds in the unsaponifiable fraction and 15 fatty acid methyl esters in the saponifiable part. Thirteen terpenes and sterols were isolated and identified from which ten compounds were not isolated from any part of this species before. Data showed that irradiation induced colon injury as manifested by elevated contents of malondialdehyde, nitric oxide, myeloperoxidase, intercellular adhesion molecule-1, cyclooxygenase-2, tumor necrosis factor alpha, and nuclear factor kappa B, while it reduced superoxide dismutase activity and interleukin 10 content in colonic tissues, which was confirmed by histopathological examination. Pretreatment with O. ficus-indica extract attenuated the alteration in the measured parameters. It could be concluded that O. ficus-indica fruit peel extract can be regarded as a potential agent in limiting colonic complications due to irradiation, possibly by its antioxidant and anti-inflammatory properties.<\/jats:p>","DOI":"10.1055\/a-1019-9801","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T22:59:10Z","timestamp":1571439550000},"page":"61-69","source":"Crossref","is-referenced-by-count":15,"title":["Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats"],"prefix":"10.1055","volume":"86","author":[{"given":"Salma A.","family":"Elsawi","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, National Research Centre, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha R.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.","family":"Elbatanony","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, National Research Centre, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal M.","family":"El-Feky","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, National Research Centre, Giza, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. H.","family":"Sherif","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,10,18]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1019-9801.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T23:31:45Z","timestamp":1578353505000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1019-9801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,6]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1019-9801","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]}}}