{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:24:56Z","timestamp":1753737896511},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Objective We purposed to investigate whether preoperative HbA1c level\n                        is associated with the severity of surgical treatment in diabetic hand\n                        infection cases.<\/jats:p><jats:p>\n                        Materials and Methods Between December 2015 and October 2018, 102\n                        patients were surgically treated due to diabetic hand infection. Of the\n                        patients, 75 who met the criteria for diabetic hand infection were included\n                        in the study. The patients were divided into two groups: Group 1, &lt;\u20098.5%\n                        HbA1c level (poorly controlled); and Group 2, 8.5% or higher HbA1c level\n                        (uncontrolled). Preoperative, intraoperative, and postoperative data were\n                        recorded. Drainage, VAC, ray\/open amputation, and microsurgical\n                        reconstruction were performed according to the examination and clinical\n                        findings. p&lt;0.05 was considered statistically significant.<\/jats:p><jats:p>\n                        Results The study groups consisted of 41 patients (5 female\/36 male;\n                        median age 59 years, range 32\u201368) in Group 1 and 34 patients (6 female\/28\n                        male; median age 62 years, range 28\u201367) in Group 2. The mean follow-up\n                        period was 21.14\u00b110.42 months in Group 1 and 16.70\u00b110.19 months in Group 2,\n                        which were not significantly different (p&gt;0.05). The most common\n                        microbiological pathogen was polymicrobial in both study groups (39% in\n                        Group 1 and 41.2% in Group 2). Drainage was the most common surgical\n                        procedure in both groups and there was no significant difference between the\n                        groups in terms of the surgical techniques that were used (p&gt;0.05).<\/jats:p><jats:p>\n                        Conclusion Although HbA1c level is an important biomarker for\n                        monitoring glycemia in diabetic patients, it is not associated with the\n                        severity of surgical treatment in diabetic hand infections.<\/jats:p>","DOI":"10.1055\/a-1025-3766","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T23:37:15Z","timestamp":1572997035000},"page":"713-721","source":"Crossref","is-referenced-by-count":3,"title":["Is the Preoperative Glycated Hemoglobin (HbA1c) Level Predictive of\n                    the Severity of Diabetic Hand Infection According to Surgical and Clinical\n                    Outcomes?"],"prefix":"10.1055","volume":"129","author":[{"given":"Kaan","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics & Traumatology, Kayseri City Hospital,\n                    Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakup","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Orthopedics & Traumatology, Kayseri City Hospital,\n                    Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1142\/S021881041100559X","article-title":"Hand infection in diabetic patients","volume":"16","author":"A Jalil","year":"2011","journal-title":"Hand Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(03)13169-8","article-title":"Diabetic foot ulcers","volume":"361","author":"W J Jeffcoate","year":"2003","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-8227(97)00058-2","article-title":"Mortality following lower extremity amputation in minorities with diabetes\n                    mellitus","volume":"37","author":"L A Lavery","year":"1997","journal-title":"Diabetes Res Clin Pract"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.diabres.2011.07.012","article-title":"Diabetic hand syndromes as a clinical and diagnostic tool for diabetes mellitus\n                    patients","volume":"94","author":"H Y Al-Matubsi","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref5","first-page":"7","article-title":"Rehabilitation of the diabetic hand\/Diyabetik el rehabilitasyonu","volume":"57","author":"Y Kirazli","year":"2011","journal-title":"Turkish J Phys Med Rehabil"},{"key":"ref6","first-page":"191","article-title":"Hand disorders associated with diabetes: A review","volume":"81","author":"A Zyluk","year":"2015","journal-title":"Acta Orthop Belg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jhsa.2008.01.038","article-title":"Hand manifestations of diabetes mellitus","volume":"33","author":"P G Fitzgibbons","year":"2008","journal-title":"J Hand Surg Am"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.diabres.2006.05.016","article-title":"Diabetes, hand and\/or foot ulcers: A cross-sectional hospital-based study in\n                    Port Harcourt, Nigeria","volume":"75","author":"C Unachukwu","year":"2007","journal-title":"Diabetes Res Clin Pract"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jhsa.2017.11.003","article-title":"Quantifying the effect of diabetes on surgical hand and forearm infections","volume":"43","author":"K Sharma","year":"2018","journal-title":"J Hand Surg Am"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1262-3636(07)70094-0","article-title":"Infections of the upper extremity in hospitalized diabetic patients: A\n                    prospective study","volume":"30","author":"A Benotmane","year":"2004","journal-title":"Diabetes Metab"},{"key":"ref11","first-page":"17","article-title":"Diabetic hand infections in the tropics","volume":"48","author":"G Gill","year":"2003","journal-title":"Diabetes Voice"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.diabres.2011.03.014","article-title":"Incidence, risk factors for amputation among patients with diabetic foot ulcer\n                    in a Chinese tertiary hospital","volume":"93","author":"X Li","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref13","first-page":"187","article-title":"Comparison of family medicine and general internal medicine on diabetes\n                    management","volume":"114","author":"K A Zoberi","year":"2017","journal-title":"Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.diabres.2011.09.009","article-title":"Impact of perioperative glycaemia and glycated haemoglobin on the outcomes of\n                    the surgical treatment of diabetic foot osteomyelitis","volume":"94","author":"J Arag\u00f3n-S\u00e1nchez","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood-glucose control with sulphonylureas or insulin compared with\n                    conventional treatment and risk of complications in patients with type 2\n                    diabetes (UKPDS 33)","volume":"352","author":"UK Prospective Diabetes Study (UKPDS) Group","year":"1998","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/jid.2011.176","article-title":"Hemoglobin A1c predicts healing rate in diabetic wounds","volume":"131","author":"A L Christman","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jdi.12319","article-title":"A new classification of diabetic nephropathy 2014: A report from Joint Committee\n                    on Diabetic Nephropathy","volume":"6","author":"M Haneda","year":"2015","journal-title":"J Diabetes Investig"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7547\/15-176","article-title":"Does baseline hemoglobin A1c level predict diabetic foot ulcer outcome or wound\n                    healing time?","volume":"107","author":"L Vella","year":"2017","journal-title":"J Am Podiatr Med Assoc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/cid\/ciw345","article-title":"Rates of community-based antibiotic prescriptions and hospital-treated\n                    infections in individuals with and without type 2 diabetes: A Danish Nationwide\n                    cohort study, 2004-2012","volume":"63","author":"A Mor","year":"2016","journal-title":"Clin Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2337\/diab.39.3.271","article-title":"Handicaps to host defense. Effects of hyperglycemia on C3 and Candida\n                    albicans","volume":"39","author":"M K Hostetter","year":"1990","journal-title":"Diabetes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0030-6665(00)80010-9","article-title":"Mucormycosis of the nose and paranasal sinuses","volume":"33","author":"B J Ferguson","year":"2000","journal-title":"Otolaryngol Clin North Am"},{"key":"ref23","first-page":"22","article-title":"Association between high risk foot, retinopathy and HbA1C in Saudi diabetic\n                    population","volume":"6","author":"KM A Aziz","year":"2010","journal-title":"Pak J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1370\/afm.679","article-title":"Competing demands or clinical inertia: The case of elevated glycosylated\n                    hemoglobin","volume":"5","author":"M L Parchman","year":"2007","journal-title":"Ann Fam Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/01.ASW.0000358639.45784.cd","article-title":"The relationship between hemoglobin A1c values and healing time for lower\n                    extremity ulcers in individuals with diabetes","volume":"22","author":"M Markuson","year":"2009","journal-title":"Adv Skin Wound Care"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"H Brem","year":"2007","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/eurheartj\/ehi199","article-title":"Intense metabolic control by means of insulin in patients with diabetes mellitus\n                    and acute myocardial infarction (DIGAMI 2): Effects on mortality and\n                    morbidity","volume":"26","author":"K Malmberg","year":"2005","journal-title":"Eur Heart J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"640","DOI":"10.7326\/0003-4819-146-9-200705010-00007","article-title":"Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk\n                    assessment: A case-control analysis in EPIC-Norfolk","volume":"146","author":"W A van der Steeg","year":"2007","journal-title":"Ann Intern Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/j.jfas.2009.08.011","article-title":"Limb-threatening and life-threatening diabetic extremities: clinical patterns\n                    and outcomes in 56 patients","volume":"49","author":"J Bahebeck","year":"2010","journal-title":"J Foot Ankle Surg"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1025-3766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T01:07:39Z","timestamp":1633396059000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1025-3766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,5]]},"references-count":28,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,4]]},"published-print":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1025-3766","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,5]]}}}