{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:49:49Z","timestamp":1789537789376,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"German Conns Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2013_A182"],"award-info":[{"award-number":["2013_A182"]}]},{"name":"German Conns Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2015_A171"],"award-info":[{"award-number":["2015_A171"]}]},{"name":"European\n Research Council (ERC) under the European Union\u2019s Horizon 2020\n research and innovation programme","award":["694913"],"award-info":[{"award-number":["694913"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG) (within\n the CRC\/Transregio 205\/1 \u201cThe Adrenal: Central Relay in Health\n and Disease\u201d to FB and MR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Abstract<\/jats:title>\n Context Recent studies support a bidirectional interaction between\n aldosterone and parathyroid hormone (PTH), possibly increasing the\n individual cardiovascular risk. Primary aldosteronism (PA) and primary\n hyperparathyroidism can occur simultaneously.<\/jats:p>\n Objective Our aim was to investigate the prevalence of\n hyperparathyroidism in PA.<\/jats:p>\n Patients We performed a case finding of primary hyperparathyroidism\n in a retrospective series of 503 patients with PA (cohort 1). We analysed\n primary and secondary hyperparathyroidism in 141 prospective PA patients who\n underwent PTH, serum calcium and phosphate measurements at time of diagnosis\n of PA (cohort 2).<\/jats:p>\n Results The prevalence for primary hyperparathyroidism was\n 1.2% in cohort 1, and 2.1% in cohort 2. Secondary\n hyperparathyroidism was found in 54.6% of the patients. Patients\n with secondary hyperparathyroidism had significantly higher aldosterone and\n lower potassium levels and took more antihypertensive medications compared\n to those with normal PTH levels. In multivariate analysis, aldosterone and\n 25-hydroxyvitamin D levels were significantly correlated with serum PTH\n levels. There was a nonsignificant trend to a higher cardiovascular\n morbidity in patients with secondary hyperparathyroidism. Patients with\n aldosterone producing adenoma had significantly higher PTH levels compared\n to patients with bilateral adrenal hyperplasia. After treatment, there was a\n significant decrease of PTH levels in both groups.<\/jats:p>\n Conclusion Patients with PA frequently have primary or secondary\n hyperparathyroidism, which is alleviated by correction of PA by surgical or\n medical means. Patients affected by secondary hyperparathyroidism seem to\n have a more severe phenotype of PA and have a trend towards more\n cardiovascular co-morbidities.<\/jats:p>","DOI":"10.1055\/a-1027-6472","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T23:55:03Z","timestamp":1573170903000},"page":"246-254","source":"Crossref","is-referenced-by-count":23,"title":["Primary and Secondary Hyperparathyroidism in Patients with Primary\n Aldosteronism \u2013 Findings From the German Conn\u2019s\n Registry"],"prefix":"10.1055","volume":"128","author":[{"given":"Evelyn","family":"Asbach","sequence":"additional","affiliation":[{"name":"Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Bekeran","sequence":"additional","affiliation":[{"name":"Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Endokrinologie,\n Medizinische Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lang","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Julius-Maximilians-Universit\u00e4t\n W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Hanslik","sequence":"additional","affiliation":[{"name":"Klinische Endokrinologie, Charit\u00e9 Campus Mitte,\n Universit\u00e4tsmedizin Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Treitl","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Radiologie, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Ladurner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral-und Endokrine Chirurgie, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"},{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Klinische\n Ern\u00e4hrung, Universit\u00e4tsspital Z\u00fcrich,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endokrinologie in Charlottenburg, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Endocrinology, Medizinische Klinik und Poliklinik IV, Klinikum der\n Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\n Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,11,7]]},"container-title":["Experimental and Clinical Endocrinology & Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1027-6472.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T22:37:17Z","timestamp":1586212637000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1027-6472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,6]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1027-6472","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]}}}