{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:19:37Z","timestamp":1788067177592,"version":"build-2784847793"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["32003B_127620 and 3200B0-114033"],"award-info":[{"award-number":["32003B_127620 and 3200B0-114033"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We hypothesised that vagal withdrawal and increased venous return interact in determining the\n     rapid cardiac output (CO) response (phase I) at exercise onset. We used lower body negative\n     pressure (LBNP) to increase blood distribution to the heart by muscle pump action and reduce\n     resting vagal activity. We expected a larger increase in stroke volume (SV) and smaller for\n     heart rate (HR) at progressively stronger LBNP levels, therefore CO response would remain\n     unchanged. To this aim ten young, healthy males performed a 50\u2009W exercise in supine\n     position at 0 (Control), \u221215, \u221230 and \u221245\u2009mmHg LBNP exposure.\n     On single beat basis, we measured HR, SV, and CO. Oxygen uptake was measured breath-by-breath.\n     Phase I response amplitudes were obtained applying an exponential model. LBNP increased SV\n     response amplitude threefold from Control to \u221245\u2009mmHg. HR response amplitude\n     tended to decrease and prevented changes in CO response. The rapid response of CO explained\n     that of oxygen uptake. The rapid SV kinetics at exercise onset is compatible with an increased\n     venous return, whereas the vagal withdrawal conjecture cannot be dismissed for HR. The rapid CO\n     response may indeed be the result of two independent yet parallel mechanisms, one acting on SV,\n     the other on HR.<\/jats:p>","DOI":"10.1055\/a-1028-7496","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T18:49:16Z","timestamp":1579546156000},"page":"209-218","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Lower Body Negative Pressure on Phase I Cardiovascular Responses at\n     Exercise Onset"],"prefix":"10.1055","volume":"41","author":[{"given":"Nazzareno","family":"Fagoni","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia,\n     Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bruseghini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia,\n     Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Adami","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Capelli","sequence":"additional","affiliation":[{"name":"Department of Physical Performances, Norwegian School of Sport Sciences, Oslo,\n     Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Lador","sequence":"additional","affiliation":[{"name":"Division de Pneumologie, D\u00e9partement des Sp\u00e9cialit\u00e9s de\n     M\u00e9decine, H\u00f4pitaux Universitaires de Gen\u00e8ve, Geneva,\n     Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Moia","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Neurosciences Fondamentales, Universit\u00e9 de\n     Gen\u00e8ve Centre M\u00e9dical Universitaire, Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Tam","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Neurologiche e della Visione, University of Verona, Verona,\n     Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Bringard","sequence":"additional","affiliation":[{"name":"University Medical Center, Basic Neurosciences, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferretti","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Neurosciences Fondamentales, Universit\u00e9 de\n     Gen\u00e8ve Centre M\u00e9dical Universitaire, Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,20]]},"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1028-7496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T09:28:57Z","timestamp":1585819737000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1028-7496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,1]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1028-7496","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}