{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T22:00:53Z","timestamp":1648936853037},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der Pseudohypoaldosteronismus Typ I ist eine seltene genetische Erkrankung einer Mineralokortikoidresistenz, die sich typischerweise im Neugeborenenalter manifestiert. Die Patienten fallen durch eine Gedeihst\u00f6rung, Dehydratation, Polyurie, Erbrechen, Hyperkali\u00e4mie, Hyponatri\u00e4mie sowie gegebenenfalls einer metabolischen Azidose bei erh\u00f6hten Aldosteron \u2013 und Plasmareninwerten auf. Das Krankheitsbild wird in eine systemische und renale Form unterteilt. Bei der renalen Form besteht nach alleiniger Kochsalzsubstitution ab dem Kleinkindesalter eine Symptomfreiheit. Bei der systemischen Form k\u00f6nnen neben den Nieren auch Kolon, Lungen, Speichel- und Schwei\u00dfdr\u00fcsen betroffen sein. Dabei zeigt sich eine Symptompersistenz bis in das Erwachsenenalter.<\/jats:p>","DOI":"10.1055\/a-1031-9679","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:07:00Z","timestamp":1578528420000},"page":"29-32","source":"Crossref","is-referenced-by-count":0,"title":["Gedeihst\u00f6rung, Hyponatri\u00e4mie, Hyperkali\u00e4mie \u2013 Differenzialdiagnostische \u00dcberlegungen einer seltenen genetischen Erkrankung"],"prefix":"10.1055","volume":"232","author":[{"given":"Andrea","family":"Tropschuh","sequence":"additional","affiliation":[{"name":"Kliniken St. Elisabeth, Klinik f\u00fcr Kinder und Jugendliche, Neuburg an der Donau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"de Potzolli","sequence":"additional","affiliation":[{"name":"Kliniken St. Elisabeth, Klinik f\u00fcr Kinder und Jugendliche, Neuburg an der Donau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Seeliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,8]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1031-9679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:07:01Z","timestamp":1578528421000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1031-9679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,8]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1031-9679","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}