{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:53:31Z","timestamp":1780491211086,"version":"3.54.1"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Die Keratoplastik z\u00e4hlt weltweit zu den am h\u00e4ufigsten durchgef\u00fchrten Gewebetransplantationen. Traditionell entfiel die \u00fcberwiegende Mehrheit der Eingriffe auf die perforierende Keratoplastik. Mit deren Weiterentwicklung in den vergangenen 15 Jahren gewann jedoch insbesondere die posteriore lamellierende Keratoplastik zur Behandlung der Fuchs-Endotheldystrophie sowie der bull\u00f6sen Keratopathie zunehmend an Bedeutung. Basierend auf informellen Umfrageergebnissen wurde postuliert, dass sich auch in Deutschland ein Trend hin zur posterioren lamellierenden Keratoplastik abzeichnet.<\/jats:p><jats:p>\n          Ziel der Arbeit Anhand der Qualit\u00e4tsberichte der Krankenh\u00e4user sollte gepr\u00fcft werden, ob der Anteil der lamellierenden Keratoplastik in Deutschland im Zeitraum 2006 bis 2017 zugenommen hat. Zudem sollte die Zahl der HLA-kompatibel (HLA: humanes Leukozytenantigen) durchgef\u00fchrten Keratoplastiken ermittelt werden.<\/jats:p><jats:p>\n          Material und Methoden Die Operationszahlen der perforierend\/lamellierend bzw. HLA-kompatibel durchgef\u00fchrten Keratoplastiken wurden anhand der OPS-Ziffern aus den Krankenhausqualit\u00e4tsberichten der Jahre 2006 bis einschlie\u00dflich 2017 extrahiert. Die deskriptive statistische Auswertung erfolgte mit dem Softwarepaket R (www.r-project.org).<\/jats:p><jats:p>\n          Ergebnisse Von 2006 bis 2017 wurden deutschlandweit insgesamt 43\u200a021 Keratoplastiken durchgef\u00fchrt. Die Zahl der durchgef\u00fchrten Keratoplastiken stieg von 2849 im Jahr 2006 auf 8231 im Jahr 2017. Die absolute Zahl perforierender Keratoplastiken blieb insgesamt konstant. Der relative Anteil lamellierender Keratoplastiken stieg von 6,5% (2006) auf 61,4% (2017) an. Die Zahl der HLA-kompatibel durchgef\u00fchrten Keratoplastiken lag stets unter 20% und war ab 2010 r\u00fcckl\u00e4ufig (2010: 19,7%; 2017: 9,8%).<\/jats:p><jats:p>\n          Diskussion Die posteriore lamellierende Keratoplastik hat auch in Deutschland stark an Stellenwert gewonnen und seit 2014 die perforierende Keratoplastik als h\u00e4ufigste Form der Keratoplastik abgel\u00f6st. Die perforierende Keratoplastik, deren absolute Zahl \u00fcber den gesamten Untersuchungszeitraum insgesamt konstant blieb, hat jedoch nach wie vor einen hohen Stellenwert bei der Behandlung von vorwiegend stromalen oder durchgreifenden Hornhautdefekten. Der Anteil HLA-kompatibler Keratoplastiken hat vermutlich insbesondere vor dem Hintergrund fehlender eindeutiger Nachweise einer Verringerung der Absto\u00dfungsraten in Standardsituationen in den letzten Jahren weiter abgenommen.<\/jats:p>","DOI":"10.1055\/a-1035-9442","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:22:15Z","timestamp":1579738935000},"page":"288-292","source":"Crossref","is-referenced-by-count":7,"title":["Die Keratoplastik in Deutschland: systematische Auswertung der Krankenhausqualit\u00e4tsberichte der Jahre 2006 bis 2017"],"prefix":"10.1055","volume":"238","author":[{"given":"Moritz Claudius","family":"Daniel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabo","family":"Lapp","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Christian","family":"Maier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Lang","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.4103\/0301-4738.100540","article-title":"Turning the tide of corneal blindness","volume":"60","author":"M S Oliva","year":"2012","journal-title":"Indian J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global survey of corneal transplantation and eye banking","volume":"134","author":"P Gain","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"ref4","first-page":"T10","article-title":"Development of selective lamellar keratoplasty within an Asian corneal transplant program: The Singapore Corneal Transplant Study (An American Ophthalmological Society Thesis)","volume":"113","author":"D Tan","year":"2015","journal-title":"Trans Am Ophthalmol Soc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajo.2018.01.018","article-title":"Trends in corneal transplantation from 2001 to 2016 in Germany: a report of the DOG-Section Cornea and its Keratoplasty Registry","volume":"188","author":"E Flockerzi","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e112696","DOI":"10.1371\/journal.pone.0112696","article-title":"Analysis of the changes in keratoplasty indications and preferred techniques","volume":"9","author":"S J Lang","year":"2014","journal-title":"PLoS One"},{"key":"ref8","first-page":"70","article-title":"[Activities of the tissue transplantation and biotechnology section of the German Ophthalmological Society: 4. 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