{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:16:56Z","timestamp":1790921816236,"version":"4.1.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Epidemiologie und Pathogenese\u2002Campylobacter jejuni\/enteritidis ist in Westeuropa zu einem der h\u00e4ufigsten Erreger der ReA geworden. Auch nach mit Reisediarrh\u00f6 assoziierten Escherischia-coli-Infektionen (DEC-Infektionen) k\u00f6nnen Arthralgien und milde ReA auftreten. HLA-B27 spielt eine Rolle bei der Erregerinvasion und -persistenz in Zellen der Mukosa und als antigenpr\u00e4sentierendes Molek\u00fcl. Neu sind Erkenntnisse, dass durch Ausl\u00f6sung einer Unfolded Protein Response (UPR) als Folge einer Fehlfaltung des HLA-B27-Molek\u00fcls eine proinflammatorische Stressantwort ausgel\u00f6st werden kann und dass enterobakterielle Infektionen diese Reaktion des angeborenen Immunsystems ausl\u00f6sen oder verst\u00e4rken.<\/jats:p><jats:p>\n          Diagnostik\u2002Die Diagnostik beruht nicht auf einzelnen Parametern, sondern auf einer Kombination von klinischen, anamnestischen und serologischen bzw. PCR-basierten Faktoren.<\/jats:p><jats:p>\n          Therapie\u2002Antibiotika werden nur zur Therapie einer noch bestehenden Chlamydophilia-trachomatis-Infektion an der Eintrittspforte (urogenital) eingesetzt, nicht aber zur Therapie der posturethritischen oder postenteritischen ReA. Bei therapierefrakt\u00e4ren chronischen Verl\u00e4ufen k\u00f6nnen Biologika (TNF-Inhibitoren) entsprechend ihrer Zulassung bei Spondyloarthritiden eingesetzt werden.<\/jats:p>","DOI":"10.1055\/a-1036-9359","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T23:48:40Z","timestamp":1606780120000},"page":"1786-1790","source":"Crossref","is-referenced-by-count":4,"title":["Reaktive Arthritis \u2013 eine vergessene Erkrankung?"],"prefix":"10.1055","volume":"145","author":[{"given":"Elisabeth","family":"M\u00e4rker-Hermann","sequence":"additional","affiliation":[{"name":"Klinik Innere Medizin IV (Rheumatologie, Klinische\u00a0Immunologie und Nephrologie), Helios Dr. Horst Schmidt Kliniken Wiesbaden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/art.504","article-title":"Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays","volume":"46","author":"J Sieper","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref2","first-page":"37","article-title":"Undifferentiated arthritis in an early synovitis out\u2010patient clinic","volume":"13","author":"J L H\u00fclsemann","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"ref3","volume-title":"Reactive arthritis: epidemiology, clinical features, and treatment","author":"M Leirisalo-Repo","year":"2006","edition":"53"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3329\/jhpn.v31i3.16515","article-title":"Enteric pathogens and reactive arthritis: a systematic review of Campylobacter, salmonella and Shigella-associated reactive arthritis","volume":"31","author":"A N Ajene","year":"2013","journal-title":"J Health Popul Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1136\/annrheumdis-2013-203431","article-title":"High frequency of reactive arthritis in adults after Yersinia pseudotuberculosis O:1 outbreak caused by contaminated grated carrots","volume":"73","author":"M Vasala","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/annrheumdis-2019-216736","article-title":"Reactive arthritis and other musculoskeletal symptoms associated with acquisition of diarrhoeagenic Escherichia coli (DEC)","volume":"79","author":"R Tuompo","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s10067-019-04522-4","article-title":"Evolving patterns of reactive arthritis","volume":"38","author":"K M Hayes","year":"2019","journal-title":"Clin Rheumatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11926-019-0863-4","article-title":"Chlamydia-Induced Reactive Arthritis: Disappearing Entity or Lack of Research?","volume":"21","author":"H Zeidler","year":"2019","journal-title":"Curr Rheumatol Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/1529-0131(199901)42:1<84::AID-ANR11>3.0.CO;2-C","article-title":"Salmonella-triggered reactive arthritis: use of polymerase chain reaction, immunocytochemical staining, and gas chromatography-mass spectrometry in the detection of bacterial components from synovial fluid","volume":"42","author":"S Nikkari","year":"1999","journal-title":"Arthritis Rheum"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/MAJ.0b013e3182648740","article-title":"Chlamydia trachomatis is present and metabolically active during the remitting phase in synovial tissues from patients with chronic Chlamydia-induced reactive arthritis","volume":"346","author":"H C G\u00e9rard","year":"2013","journal-title":"Am J Med Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1056\/NEJM198901263200404","article-title":"Yersinia antigens in synovial-fluid cells from patients with reactive arthritis","volume":"320","author":"K Granfors","year":"1989","journal-title":"N Engl J Med"},{"key":"ref12","first-page":"348","article-title":"Synovial T lymphocyte recognition of organisms that trigger reactive arthritis","volume":"76","author":"J S Gaston","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"ref13","first-page":"365","article-title":"Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis","volume":"75","author":"E Hermann","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/rheumatology\/41.6.651","article-title":"Invasion of Salmonella into human intestinal epithelial cells is modulated by HLA-B27","volume":"41","author":"M Saarinen","year":"2002","journal-title":"Rheumatology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0140-6736(93)91760-J","article-title":"HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis","volume":"342","author":"E Hermann","year":"1993","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/annrheumdis-2018-213532","article-title":"Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication","volume":"78","author":"A N Antoniou","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/art.1780391211","article-title":"Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter\u2019s syndrome). A Department of Veterans Affairs Cooperative Study","volume":"39","author":"D O Clegg","year":"1996","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"BSR20191927","DOI":"10.1042\/BSR20191927","article-title":"Treatment of reactive arthritis with biological agents: a review","volume":"40","author":"H Zeng","year":"2020","journal-title":"Biosci Rep"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1036-9359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T23:49:41Z","timestamp":1606780181000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1036-9359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":18,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1036-9359","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}