{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:05:40Z","timestamp":1649016340403},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Zur Therapie weit fortgeschrittener Glaukome stehen verschiedene Verfahren zur Verf\u00fcgung. Wir untersuchten die Effektivit\u00e4t und Therapiesicherheit der fraktionierten Zyklophotokoagulation (CPC) mit bis zu 10 Herden f\u00fcr fortgeschrittene prim\u00e4re Offenwinkelglaukome (POWG) und Pseudoexfoliationsglaukome (PEX-Glaukome), die mit maximaler topischer Therapie behandelt wurden oder eine Augentropfenunvertr\u00e4glichkeit aufwiesen.<\/jats:p><jats:p>\n          Material und Methoden In dieser retrospektiven Studie wurden die Daten von 297 Augen ausgewertet, die zwischen Feb. 2012 und Jun. 2017 eine CPC von je 10 Herden erhielten und an einem fortgeschrittenen POWG bzw. einem PEX-Glaukom litten. Ausgewertet wurden Augeninnendruck (IOD), Anzahl drucksenkender Wirkstoffe sowie postoperative Komplikationen. Die Daten wurden pr\u00e4operativ, 4 Wochen postoperativ sowie zum letzten dokumentierten Kontakt (i.\u200ad.\u200aR. 6\u00a0Monate postoperativer Visit) erhoben. F\u00fcr die Analyse der \u00c4nderungen wurde der gepaarte Wilcoxon-Rangsummentest verwendet.<\/jats:p><jats:p>\n          Ergebnisse Der IOD ist f\u00fcr die POWG von 16,66\u2009\u00b1\u20094,36\u2009mmHg pr\u00e4operativ auf 13,87\u2009\u00b1\u20093,59\u2009mmHg zum letzten Visit (i.\u200ad.\u200aR. 6 Monate postoperativer Visit) statistisch signifikant (p\u2009&lt;\u20090,05) gesunken. Der IOD ist f\u00fcr die PEX-Glaukome von 20,76\u2009\u00b1\u20099,55\u2009mmHg pr\u00e4operativ auf 15,50\u2009\u00b1\u20095,93\u2009mmHg zum letzten Visit signifikant (p\u2009&lt;\u20090,003) gesunken. Die Anzahl der drucksenkenden Wirkstoffe lag beim POWG pr\u00e4operativ bei 2,51\u2009\u00b1\u20091,00; beim letzten Visit bei 2,27\u2009\u00b1\u20091,03 sowie beim PEX-Glaukom pr\u00e4operativ bei 2,46\u2009\u00b1\u20091,07; beim letzten Visit bei 1,88\u2009\u00b1\u20090,97.\u2009Behandlungsbed\u00fcrftige Komplikationen traten insgesamt bei 3 Augen auf, es zeigten sich 2 postoperative Makula\u00f6deme, die sich mit systemischen Steroiden gut behandeln lie\u00dfen, sowie ein therapiebed\u00fcrftiger Vorderkammerreizzustand mit Hyph\u00e4ma, der ebenfalls mit topischen Steroiden behandelt wurde.<\/jats:p><jats:p>\n          Schlussfolgerung Auch die von uns durchgef\u00fchrte milde CPC mit maximal 10 Herden (vs. der oft applizierten 20\u200a\u2013\u200a30 Herde) zeigt in unserem Kollektiv eine gute Augeninnendrucksenkung mit im Mittel einer Reduktion der zu applizierenden topischen Antiglaukomatosa bei geringer Komplikationsrate.<\/jats:p>","DOI":"10.1055\/a-1057-9699","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:02Z","timestamp":1580774402000},"page":"598-602","source":"Crossref","is-referenced-by-count":0,"title":["Effektivit\u00e4t und Therapiesicherheit der fraktionierten Zyklophotokoagulation mit bis zu 10 Herden f\u00fcr fortgeschrittene prim\u00e4re Offenwinkel- und Pseudoexfoliationsglaukome"],"prefix":"10.1055","volume":"238","author":[{"given":"Carsten","family":"Grohmann","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaz","family":"Farrokhi","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Klemm","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Hamburg-Eppendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00347-014-3161-6","article-title":"Tiefe Sklerektomie: Eine Alternative zur Trabekulektomie","volume":"112","author":"M Klemm","year":"2015","journal-title":"Ophthalmologe"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"983102","DOI":"10.1155\/2014\/983102","article-title":"Dose-response-relationship between number of laser burns and IOP reduction in cyclophotocoagulation: an animal study","volume":"2014","author":"L Wagenfeld","year":"2014","journal-title":"Biomed Res 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