{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:36:38Z","timestamp":1763037398155},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2002Angiodysplasia (AD) is a common source of gastrointestinal bleeding. Yet, little is known about factors forwarding bleeding in these vascular malformations. The presented study aims to determine risk factors for bleeding that occurs only in patients with symptomatic, but not with asymptomatic, AD.<\/jats:p><jats:p>\n          Methods\u2002Case-control study in patients with AD\u200aand either a positive or a negative history of gastrointestinal bleeding in Munich, Germany. Groups were compared by clinical, laboratory, and endoscopic features.<\/jats:p><jats:p>\n          Results\u200280 patients with (58, f 31, med. age 72) or without bleeding AD\u200a(22, f 12, med. age 61) were included. Bleeding from AD\u200awas significantly associated with the total number of AD\u200a(OR 1.4 (95\u200a% CI 1.1\u20131.7) p\u200a=\u200a0.01) and closure time in PFA\/collagen-epinephrine test (OR 1.0 (95\u200a% CI 1.0\u20131.0) p\u200a&lt;\u200a0.01). The total number of AD\u200acorrelated significantly with age (r\u200a=\u200a0.36; p\u200a=\u200a0.01). AD\u200awere mainly detected in the upper small intestine (&gt;\u200a30\u200a%). Although patients with aortic stenosis suffered not significantly more frequently from bleeding from AD, they demonstrated a loss of high molecular multimers of VWF.<\/jats:p><jats:p>\n          Conclusions\u2002The amount of AD\u200ais clearly correlated to the age of the patient. A higher number of ADs and inhibition of primary hemostasis increase the risk of bleeding.<\/jats:p>","DOI":"10.1055\/a-1068-3014","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:16:18Z","timestamp":1580861778000},"page":"234-240","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for bleeding from gastrointestinal angiodysplasia: a\u00a0case-control study in patients with bleeding and non-bleeding angiodysplasia"],"prefix":"10.1055","volume":"58","author":[{"given":"Bruno","family":"Neu","sequence":"additional","affiliation":[{"name":"II. Medizinische Klinik, Krankenhaus Landshut, Germany"},{"name":"Krankenhaus Landshut Achdorf, Academic Teaching Hospital, Technische Universit\u00e4t M\u00fcnchen, Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Moessmer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Chemie und Pathobiochemie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monther","family":"Bajbouj","sequence":"additional","affiliation":[{"name":"II. Medizinische Klinik, Krankenhaus Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Becker","sequence":"additional","affiliation":[{"name":"II. Medizinische Klinik, Krankenhaus Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Barthel","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik, all Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Seidl","sequence":"additional","affiliation":[{"name":"Klinikum M\u00fcnchen-Bogenhausen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Schepp","sequence":"additional","affiliation":[{"name":"Klinikum M\u00fcnchen-Bogenhausen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Anzinger","sequence":"additional","affiliation":[{"name":"Klinikum M\u00fcnchen-Neuperlach, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dollhopf","sequence":"additional","affiliation":[{"name":"Klinikum M\u00fcnchen-Neuperlach, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Meining","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Uniklinikum W\u00fcrzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland M.","family":"Schmid","sequence":"additional","affiliation":[{"name":"II. Medizinische Klinik, Krankenhaus Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Budde","sequence":"additional","affiliation":[{"name":"Haemostaseology, Medilys Laborgesellschaft mbH, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Noe","sequence":"additional","affiliation":[{"name":"II. Medizinische Klinik, Krankenhaus Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,4]]},"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1068-3014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:38:42Z","timestamp":1584751122000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1068-3014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,4]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,3,20]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1068-3014","relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"value":"0044-2771","type":"print"},{"value":"1439-7803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,4]]}}}