{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:30:45Z","timestamp":1772641845818,"version":"3.50.1"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2002Congenital corrected transposition of the great arteries (ccTGA) is a rare congenital cardiac anomaly which remains difficult to diagnose prenatally. We aim to investigate the natural history, associated anomalies and the outcome of patients in prenatally diagnosed ccTGA.<\/jats:p><jats:p>Method\u2002This was an international multicenter retrospective analysis of fetuses with a diagnosis of ccTGA from 2002 to 2017. We reviewed clinical and echocardiographic databases of seven centers. Anatomic survey and fetal echocardiography were performed according to international guidelines of ISUOG.<\/jats:p><jats:p>Results\u2002We considered 69 fetuses with prenatally suspected ccTGA. There was an overall survival rate of 91\u200a% among 54\u00a0patients with a confirmed diagnosis. Survival to live birth was 96\u200a% (52\/54) and survival on an intention-to-treat basis was 94\u200a% (49\/52). The mean gestational age at the time of diagnosis was 25.6\u200a\u00b1\u200a5.9 weeks of gestation. In 7 out of 54\u00a0fetuses (13\u200a%), ccTGA was an isolated finding. Dextro\/mesocardia was present in 15 cases (27.8\u200a%). Intracardiac anomalies were present in 46\/54 cases (85.2\u200a%) with the most frequent anomaly being a ventricular septal defect present in 41 fetuses (75.9\u200a%). Complete heart block was diagnosed in 10 cases (18.5\u200a%). Extracardiac anomalies were observed in 9 out of 54 cases (16.7\u200a%). Prenatal karyotyping of the fetus was available in 30\/54 (55.6\u200a%) cases with chromosomal anomalies in 4\/30 (13.3\u200a%).<\/jats:p><jats:p>Conclusion\u2002ccTGA is a rare cardiac anomaly often accompanied by a variable spectrum of further intracardiac abnormalities. Accurate diagnosis of ccTGA, which can be integrated into parental counselling, is feasible with a favorable short-term outcome for affected neonates.<\/jats:p>","DOI":"10.1055\/a-1069-7698","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T23:44:06Z","timestamp":1580341446000},"page":"291-296","source":"Crossref","is-referenced-by-count":10,"title":["Prenatal Diagnosis and Outcome of Congenital Corrected Transposition of the Great Arteries \u2013 A Multicenter Report of 69 Cases"],"prefix":"10.1055","volume":"42","author":[{"given":"Carina Nina","family":"Vorisek","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Enzensberger","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Willomeit","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrii","family":"Kurkevych","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit, Ukrainian Children\u2019s Hospital, Kyiv, UA, Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Stessig","sequence":"additional","affiliation":[{"name":"Prenatal Plus, Prenatal Care Center Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Ritgen","sequence":"additional","affiliation":[{"name":"Prenatal Plus, Prenatal Care Center Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Degenhardt","sequence":"additional","affiliation":[{"name":"Prenatal Plus, Prenatal Care Center Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunther","family":"Mielke","sequence":"additional","affiliation":[{"name":"Prenatal Medicine, Prenatal Care Center Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Bosselmann","sequence":"additional","affiliation":[{"name":"Prenatal Medicine, Prenatal Care Center Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Krapp","sequence":"additional","affiliation":[{"name":"Prenatal Care Center, amedes Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Slodki","sequence":"additional","affiliation":[{"name":"Fetal Cardiology, Polish Mother Memorial Hospital Research Institute, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Respondek-Liberska","sequence":"additional","affiliation":[{"name":"Department of Prenatal Cardiology, Polish Mother\u2019s Memorial Hospital Research Institute, Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Wolter","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kawecki","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malena","family":"Goette","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Department of OB&GYN, Division of Prenatal Medicine, University-Hospitals Gie\u00dfen and Marburg Campus Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"ref1","first-page":"375","article-title":"Report of the New England Regional Infant Cardiac Program","volume":"65","author":"D C Fyler","year":"1980","journal-title":"Pediatrics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1542\/peds.20.4.626","article-title":"Corrected transposition of the great vessels of the heart: a review of 17 cases","volume":"20","author":"R C Anderson","year":"1957","journal-title":"Pediatrics"},{"key":"ref3","first-page":"701","volume-title":"Corrected 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