{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:16:22Z","timestamp":1773422182024,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim\u2002To proof the feasibility of manufacturing patient-indivdual (anthropomorphic) thyroid replicas from I-124 PET DICOM datasets by means of 3D printing. A possible field of application is the use of those phantoms for the calibration of gamma probes.<\/jats:p><jats:p>\n          Methods\u2002After editing of the DICOM datasets using several software types and transferring into a dedicated stereolithography format, 10 fillable thyroid replicas (35\u2013200\u200amL) made of polylactide acid were manufactured via 3D printing. All replicas were filled with a water-solution containing 3.5\u200aMBq I-131 and applied to a standard neck phantom. Calibration factor measurements were carried out using a clinical gamma probe. Measurements were performed with three different tilts: +\u200a15\u00b0, 0\u00b0 and \u201315\u00b0. The influence of the replicas\u2019 volume and the tilt was investigated.<\/jats:p><jats:p>\n          Results\u2002Manufacturing of the replicas was successful in all cases. The time required for data processing was 13\u200a\u00b1\u200a2 (median: 12, range: 9\u201325) min and 4\u201311\u200ah for 3D printing (size-dependent). The printing process could be done overnight. Measured mean calibration factor for straight gamma probe positioning (0\u00b0 tilt) was 31\u200a965\u200a\u00b1\u200a3360 (33\u200a893, 25\u200a470\u201334\u200a253) cpm\/MBq. A tilt of \u201315\u00b0 resulted in lower calibration factors (\u20137.7\u200a%), whereas a tilt of +\u200a15\u00b0 led to higher values (+\u200a9.5\u200a%); p\u200a=\u200a0.001. The calibration factors were highly inversely proportional correlated to the volume of the replicas (r\u200a=\u200a\u20130.91, p\u200a&lt;\u200a0.001).<\/jats:p><jats:p>\n          Conclusion\u20023D printing of patient-individual (anthropomorphic) fillable thyroid replicas was feasable for a large range of volumes. The study demonstrates the influence of the volume as well as the tilt of the measured object for calibration factor measurements with gamma probes.<\/jats:p>","DOI":"10.1055\/a-1070-9874","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T23:53:57Z","timestamp":1576799637000},"page":"12-19","source":"Crossref","is-referenced-by-count":5,"title":["3D printing of fillable individual thyroid replicas based on nuclear medicine DICOM data used as phantoms for gamma probe calibration"],"prefix":"10.1055","volume":"59","author":[{"given":"Christian","family":"K\u00fchnel","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine, Jena-University-Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Seifert","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine, Jena-University-Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Mulik","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine, Jena-University-Hospital, Jena, Germany"},{"name":"Medical Engineering and Biotechnology University of Applied Sciences Jena (EAH-Jena), Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Winkens","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine, Jena-University-Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Freesmeyer","sequence":"additional","affiliation":[{"name":"Clinic of Nuclear Medicine, Jena-University-Hospital, Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,19]]},"container-title":["Nuklearmedizin"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1070-9874.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T23:47:59Z","timestamp":1580860079000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1070-9874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,2,4]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1070-9874","relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,19]]}}}