{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:28:13Z","timestamp":1761017293298,"version":"3.37.3"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"The Latvian State Genome database project and Latvian\n                        Association of Endocrinology."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Background Serum angiopoietin 2 levels have been associated with\n                    endothelial dysfunction and diabetic kidney disease. Derangements in autonomous\n                    nervous system lead to increased production of vasoconstrictory and angiogenic\n                    mediators such as norepinephrine and neuropeptide Y and are associated with\n                    increased risk of microvascular complications.<\/jats:p><jats:p>\n                    Aim To investigate associations between angiopoietin 2, neuropeptide Y\n                    and diabetic kidney disease in patients with type 1 diabetes mellitus.<\/jats:p><jats:p>\n                    Methods 289 patients with type 1 diabetes mellitus duration &gt; 1\n                    year were included. Patients were stratified according to presence of diabetic\n                    nephropathy (macroalbuminuria, estimated glomerular filtration\n                        rate&lt;60\u2009ml\/min\/1.73\u2009m2 or\n                    end-stage renal disease). Angiopoietin 2 was measured by Luminex technology.\n                    Neuropeptide Y was measured by ELISA.<\/jats:p><jats:p>\n                    Results Patients with diabetic nephropathy had significantly increased\n                    levels of angiopoietin 2 (4020.5 (2172.4\u20135778.1)\u2009pg\/ml\n                        vs. 2001.0 (1326.7\u20132862.7)\u2009pg\/ml) and\n                    neuropeptide Y (18.22 (14.85\u201321.85)\u2009ng\/ml vs.\n                    12.91 (9.96\u201317.07)\u2009ng\/ml). Higher levels of angiopoietin\n                    2 and neuropeptide Y were observed also in patients with arterial hypertension.\n                    Angiopoietin 2 and neuropeptide Y correlated significantly\n                    (\u03c1=0.245, p&lt;0.001). Both biomarkers were significant\n                    predictors of estimated glomerular filtration rate and diabetic nephropathy in\n                    univariate regression models. In the fully adjusted regression models and after\n                    application of a stepwise selection regression method, angiopoietin 2\n                    demonstrated a stronger predictive power for diabetic nephropathy compared to\n                    neuropeptide Y.<\/jats:p><jats:p>\n                    Conclusion Diabetic nephropathy is associated with increased serum\n                    concentrations of angiopoietin 2 (marker of endothelial dysfunction) and\n                    neuropeptide Y (marker of sympathetic activity) in type 1 diabetes. Angiopoietin\n                    2 is a more potent predictor of diabetic nephropathy compared to neuropeptide\n                    Y.<\/jats:p>","DOI":"10.1055\/a-1079-4711","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T23:52:57Z","timestamp":1579564377000},"page":"654-662","source":"Crossref","is-referenced-by-count":9,"title":["Angiopoietin 2 and Neuropeptide Y are Associated with Diabetic Kidney\n                    Disease in Type 1 Diabetes Mellitus"],"prefix":"10.1055","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-8229","authenticated-orcid":false,"given":"Jelizaveta","family":"Sokolovska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Latvia, Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juris","family":"Stefanovics","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Latvia, Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gita","family":"Gersone","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Human Physiology and Biochemistry,\n                    Riga Stradins University, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonora","family":"Pahirko","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Mathematics and Optometry, University of Latvia,\n                    Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janis","family":"Valeinis","sequence":"additional","affiliation":[{"name":"Faculty of Physics, Mathematics and Optometry, University of Latvia,\n                    Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanita","family":"Kalva-Vaivode","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Latvia, Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vita","family":"Rovite","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, Riga,\n                    Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leons","family":"Blumfelds","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Human Physiology and Biochemistry,\n                    Riga Stradins University, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdis","family":"Pirags","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Latvia, Riga, Latvia"},{"name":"Pauls Stradins Clinical University Hospital, Riga, Latvia"},{"name":"Latvian Biomedical Research and Study Centre, Riga,\n                    Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peteris","family":"Tretjakovs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Human Physiology and Biochemistry,\n                    Riga Stradins University, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.2337\/dci18-0033","article-title":"Management of Hyperglycemia in Type 2 Diabetes, 2018. 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Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1177\/1932296816636894","article-title":"Aspects of hyperglycemia contribution to arterial stiffness and cardiovascular\n                    complications in patients with type 1 diabetes","volume":"10","author":"D Gordin","year":"2016","journal-title":"Journal of Diabetes Science and Technology"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1159\/000486225","article-title":"A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors\n                    in Humans","volume":"45","author":"M Yi","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1056\/NEJMoa013410","article-title":"Increase in nocturnal blood pressure and progression to microalbuminuria in type\n                    1 diabetes","volume":"347","author":"E Lurbe","year":"2002","journal-title":"N Engl J 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involved in development of diabetic\n                    retinopathy and retinal neovascularization","volume":"36","author":"M Koulu","year":"2004","journal-title":"Ann Med"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1093\/ndt\/gfx351","article-title":"Neuropeptide Y and chronic kidney disease progression: a cohort study","volume":"33","author":"C Zoccali","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"E55","DOI":"10.1152\/ajpendo.00438.2010","article-title":"Hormonal regulation of energy-protein homeostasis in hemodialysis patients: An\n                    anorexigenic profile that may predispose to adverse cardiovascular outcomes","volume":"300","author":"M Suneja","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1507\/endocrj.46.139","article-title":"Elevated plasma immunoreactive neuropeptide Y concentrations and its increased\n                    urinary excretion in patients with advanced diabetic nephropathy","volume":"46","author":"C Satoh","year":"1999","journal-title":"Endocr J"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.mvr.2010.07.010","article-title":"The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is\n                    associated with increased levels of inflammatory markers preceding vascular\n                    complications in patients with type 2 diabetes","volume":"80","author":"U Jaakkola","year":"2010","journal-title":"Microvasc Res"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-2006-924079","article-title":"The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of\n                    onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects\n                    with diabetic retinopathy","volume":"114","author":"U Jaakkola","year":"2006","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1097\/01.asn.0000089026.28617.33","article-title":"Prospective study of neuropeptide y as an adverse cardiovascular risk factor in\n                    end-stage renal disease","volume":"14","author":"C Zoccali","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1097\/HJH.0b013e32833bd21b","article-title":"Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide\n                    Y levels in predicting left ventricular hypertrophy in dialysis patients","volume":"28","author":"A Testa","year":"2010","journal-title":"J Hypertens"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1159\/000063296","article-title":"Plasma neuropeptide Y concentrations in patients on 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Pract"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1475-2840-10-55","article-title":"Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: A\n                    cross-sectional study","volume":"10","author":"S Rasul","year":"2011","journal-title":"Cardiovasc Diabetol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.joen.2009.03.0055","article-title":"Neuropeptides regulate expression of angiogenic growth factors in human dental\n                    pulp fibroblasts","volume":"35","author":"I A El Karim","year":"2009","journal-title":"J Endod"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1079-4711.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T22:50:41Z","timestamp":1602111041000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1079-4711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,7]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1079-4711","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}