{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:24:05Z","timestamp":1753737845326},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch med Wochenschr"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>In dieser Fallserie werden 3 Patienten mit einer Dermatomyositis bzw. Polymyositis autoimmuner Genese vorgestellt, die nach Entwicklung einer rasch progredienten interstitiellen Lungenbeteiligung trotz Immunsuppressiva innerhalb von Monaten verstarben. Alle 3 Patienten hatten ein passendes Antik\u00f6rperprofil \u2013 bei 2 wurden Myositis-spezifische anti-melanoma-differentiation-associated-gene (MDA5)-Antik\u00f6rper und bei der dritten Myositis-assoziierte Anti-Ku-Antik\u00f6rper nachgewiesen. Dermatomyositis und Polymyositis sind seltene Autoimmunerkrankungen mit unterschiedlichen klinischen Manifestationen und Antik\u00f6rperkonstellationen. Insbesondere das Vorliegen von MDA5-Antik\u00f6rpern ist mit einer rasch progredienten pulmonalen Beteiligung und einer schlechten Prognose assoziiert.<\/jats:p>","DOI":"10.1055\/a-1082-0143","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T23:41:06Z","timestamp":1584661266000},"page":"394-398","source":"Crossref","is-referenced-by-count":2,"title":["Progrediente pulmonale Beteiligung bei amyopathischer Dermatomyositis"],"prefix":"10.1055","volume":"145","author":[{"given":"David","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ruhrgebiet, Ruhr-Universit\u00e4t Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Andreica","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ruhrgebiet, Ruhr-Universit\u00e4t Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Braun","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ruhrgebiet, Ruhr-Universit\u00e4t Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,19]]},"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1082-0143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T23:41:17Z","timestamp":1584661277000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1082-0143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,3,19]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1082-0143","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}