{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:30:07Z","timestamp":1777465807509,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"This research was performed independently of any funding as part\n                of institutional activities of the investigators and researchers."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Women with PCOS are linked to insulin resistance, inflammation, and vitamin D\n(VD) deficiency. The study endeavors to comprehend the differential impact\nof insulin sensitizers vs. anti-androgen on serum leptin levels among women\nwith PCOS rendered vitamin D replete with high VD oral supplement. This was\nopen-labeled randomized study that screened 180 eligible women presenting to\nEndocrine clinic with oligomenorrhea or features of hyperandrogenism.\nNinety-nine women who furnished written informed consent and fulfilled the\nRotterdam 2003 criteria for diagnosis of PCOS were randomized into 3 drug\ntreatment arms to receive either spironolactone (50\u2009mg\/d;\nn=30), metformin (1000\u2009mg\/d; n=30) or\npioglitazone (30\u2009mg\/d; n=30). These women were also\nadministered oral VD (4000 IU\/day) in addition to the allocated drug\nfor a period of 6 months. Detailed history, clinical examination, and\nlaboratory evaluation was carried out at baseline and 6 months after\nintervention. Number of menstrual cycles\/year increased while as\nFerriman\u2013Gallwey score, blood glucose, HOMA-IR, and plasma insulin\nlevels significantly decreased in all the three arms with better outcomes in\nspironolactone and pioglitazone arms (p&lt;0.05). Similarly, serum\nleptin levels superiorly improved in spironolactone and pioglitazone group.\nPioglitazone group showed better efficacy in lowering serum total\ntestosterone (p&lt;0.05). Co-supplementation of high dosage VD with\nspironolactone or pioglitazone are more effective in reducing plasma leptin\nlevels than metformin, and thus might prove to be better therapeutic\nstrategies for women with PCOS.<\/jats:p>","DOI":"10.1055\/a-1084-5441","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:14:06Z","timestamp":1581639246000},"page":"89-94","source":"Crossref","is-referenced-by-count":8,"title":["Differential Impact of Insulin Sensitizers vs. Anti-Androgen on Serum\nLeptin Levels in Vitamin D Replete PCOS Women: A Six Month Open Labeled\nRandomized Study"],"prefix":"10.1055","volume":"52","author":[{"given":"Aafia","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Ashraf","family":"Ganie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imtiyaz Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulzar Ahmad","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feroz","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Radio-Diagnosis, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishfaq Ahmed","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sheri-Kashmir Institute of Medical\nSciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, All India Institute of Medical Sciences,\nNew Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaffar Amin","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Immunology & Molecular Medicine, Sheri-Kashmir\nInstitute of Medical Sciences, Srinagar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,13]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1084-5441.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:14:11Z","timestamp":1581639251000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1084-5441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1084-5441","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}