{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T01:29:37Z","timestamp":1648862977904},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>\n            Purpose\u2002Evaluation of the efficacy and safety of chemical renal denervation by image-guided periarterial ethanol injection in pigs with emphasis on histopathological characteristics.<\/jats:p><jats:p>\n            Materials and Methods\u2002Unilateral renal periarterial ethanol injection under general anesthesia was performed in 16 animals with the contralateral kidney serving as the control. All interventions were performed in an open MRI system under real-time multiplanar guidance. In 10 pigs an ethanol-carbostesin contrast agent mixture was injected with amounts of 5\u200aml (6 animals, group I) and 10\u200aml (4 animals, group II). 6\u00a0pigs (group III) were treated with 10\u200aml of an ethanol-polyacrylic (2\u200a%) mixture. Four weeks after treatment, all animals underwent MRI including MRA. After euthanasia, macroscopic and histologic examination of the kidneys, renal arteries and periarterial tissue was performed to assess nerve injury and potential side effects. Furthermore, the norepinephrine concentration (RTNEC) in the renal tissue was determined as a surrogate parameter of efficacy.<\/jats:p><jats:p>\n            Results\u2002Histologic signs of nerval degeneration with various degrees of severity and circumferential distribution were found in all groups. Injury depths ranged up to 7.6\u200amm. In groups II and III the nerve count was significantly lower on the treated side. Renal artery stenosis was not observed in any pig. In all pigs of group II treatment resulted in neural degeneration with a mean RTNEC reduction of 53\u200a% (p\u200a&lt;\u200a0.02). In groups I and III significant changes in RTNEC were not observed.<\/jats:p><jats:p>\n            Conclusion\u2002Image-guided percutaneous periarterial ethanol injection was efficient and safe for renal denervation. The detected variations in histologic outcome underlined the importance of the preclinical optimization of the technique in order to maximize treatment effects in humans.<\/jats:p><jats:p>\n            Key Points:\n          <\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1085-2645","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T20:13:17Z","timestamp":1580242397000},"page":"549-560","source":"Crossref","is-referenced-by-count":1,"title":["Renal Sympathetic Denervation by Image-Guided Percutaneous Ethanol Injection \u2013 Histopathologic Characteristics, Efficacy and Safety"],"prefix":"10.1055","volume":"192","author":[{"given":"Patrick","family":"Freyhardt","sequence":"additional","affiliation":[{"name":"University Witten\/Herdecke, Faculty of Health, School\u00a0of\u00a0Medicine, Witten, Germany"},{"name":"Department of Diagnostic and Interventional Radiology, HELIOS Hospital Krefeld, Krefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Haage","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, HELIOS University Hospital Wuppertal, Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Walter","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Radiology,  Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Aufmesser-Freyhardt","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, HELIOS Hospital Krefeld, Krefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf W.","family":"Guenther","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Radiology,  Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Streitparth","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ludwig-Maximilians-University Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,28]]},"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1085-2645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T02:40:07Z","timestamp":1590633607000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1085-2645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,28]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,5,27]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1085-2645","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,28]]}}}