{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:52:09Z","timestamp":1782913929611,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Characteristic Cultivation Program for Subject Research of Guangzhou University of Chinese Medicine","award":["XKP2019007"],"award-info":[{"award-number":["XKP2019007"]}]},{"name":"Key Program for Subject Research of Guangzhou University of Chinese Medicine","award":["XK2019002"],"award-info":[{"award-number":["XK2019002"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2019A1515010815"],"award-info":[{"award-number":["2019A1515010815"]}]},{"name":"Natural Science Foundation of Shenzhen University General Hospital","award":["SUGH2018QD035 & SUGH2018QD070"],"award-info":[{"award-number":["SUGH2018QD035 & SUGH2018QD070"]}]},{"name":"Traditional Chinese Medicine Bereau of Guangdong Province","award":["No.20181121"],"award-info":[{"award-number":["No.20181121"]}]},{"name":"Youth Innovative Talents Project of Colleges and Universities of Guangdong Province","award":["2018KQNCX216"],"award-info":[{"award-number":["2018KQNCX216"]}]},{"name":"Key Disciplines Construction Projects of High-level University of Guangdong Province, Specific Research Project of Science and Technology of Guangdong Provincial Hospital of TCM","award":["No.YN2016QJ05"],"award-info":[{"award-number":["No.YN2016QJ05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized by an accumulation of hepatic lipids. Patchouli oil (PO), which is isolated from the well-known Chinese herb named Pogostemon cablin (Blanco) Benth. (Lamiaceae), inhibits hepatic lipid accumulation effectively. However, its potential ability for the treatment of NAFLD had not been reported before. Thus, the objective of this study was to investigate the effectiveness of PO against hepatic steatosis and its underlying mechanisms. We used a high fat diet (HFD)-induced hepatic steatosis model of rats to estimate the effect of PO against NAFLD. Hematoxylin-eosin and oil red O staining were used to analyze the hepatic histopathological changes. ELISA, RT-qPCR, and Western blotting analysis were applied to evaluate the parameters for hepatic steatosis. Our results showed that PO significantly attenuated the lipid profiles and the serum enzymes, evidenced by quantitative and histopathological analyses. It also markedly down-regulated the expression of sterol regulatory element-binding protein 1 (SREPB-1c) with its downstream factors in de novo lipogenesis. And, likewise, in lipid export by very low-density lipoproteins (VLDL), related molecules were dramatically improved. Furthermore, PO observably normalized the aberrant peroxisome proliferator-activated receptor \u03b1 (PPAR-\u03b1) signal in fatty acids oxidation. In conclusion, PO exerted a preventing effect against HFD-induced steatosis and might be due to decrease de novo lipogenesis, promote export of lipids, as well as owing to improve fatty acids oxidation.<\/jats:p>","DOI":"10.1055\/a-1087-7405","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T01:18:48Z","timestamp":1579828728000},"page":"255-266","source":"Crossref","is-referenced-by-count":11,"title":["Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis"],"prefix":"10.1055","volume":"86","author":[{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou, Guangzhou University of Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong-Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xuan","family":"Gan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Quan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ran","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory Animal Management Office, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ren","family":"Su","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Peng","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,23]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1087-7405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:31:22Z","timestamp":1583364682000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1087-7405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,3,4]]},"published-print":{"date-parts":[[2020,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1087-7405","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,23]]}}}