{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:11:54Z","timestamp":1706573514128},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Eine Antibiotikaprophylaxe bei Patienten mit oberer gastrointestinaler Blutung bei Leberzirrhose reduziert das Risiko f\u00fcr bakterielle Infektionen sowie die Fr\u00fchmortalit\u00e4t signifikant. Ziel der Studie ist es, den aktuellen Stand der Antibiotikaprophylaxe in gastroenterologischen Abteilungen in Deutschland zu erheben.<\/jats:p><jats:p>\n          Methodik\u2002Evaluation zu Indikation, Dauer und Wahl des Antibiotikums bei einer \u00d6sophagusvarizenblutung bei Leberzirrhose durch eine Befragung von gastroenterologischen Abteilungen in Deutschland.<\/jats:p><jats:p>\n          Ergebnisse\u2002Von 779 kontaktierten Gastroenterologien haben 326 an der Studie teilgenommen. 98,5\u200a% der befragten Kliniken f\u00fchren eine prophylaktische Antibiotikagabe bei \u00d6sophagusvarizenblutungen bei Leberzirrhose durch (n\u200a=\u200a321\/326). Das Child-Pugh-Stadium der Leberzirrhose war nur in 7,1\u200a% (n\u200a=\u200a23\/322) der F\u00e4lle wichtig bei der Entscheidung zur Antibiotikagabe. Eine prophylaktische Antibiotikatherapie wurde auch in 19,4\u200a% (n\u200a=\u200a62\/320) der F\u00e4lle vor einem elektiven \u00d6sophagusvarizenbanding ohne Blutung gegeben. Cephalosporine der 3. Generation sind die am h\u00e4ufigsten verwendeten Antibiotika (66,5\u200a%; n\u200a=\u200a248\/373), gefolgt von Fluorchinolonen (19,9\u200a%; n\u200a=\u200a74\/373). Die Prophylaxe wird in 32,3\u200a% der F\u00e4lle (n\u200a=\u200a104\/322) f\u00fcr 3 Tage durchgef\u00fchrt, in 9,3\u200a% (n\u200a=\u200a30\/322) f\u00fcr 1 Tag und entsprechend nur in 24,8\u200a% (n\u200a=\u200a80\/322) \u00fcber den in den deutschen Leitlinien empfohlenen Zeitraum von 7 Tagen. Ein hausinterner SOP (standard of procedure) zur Antibiotikaprophylaxe ist nur in 45,1\u200a% (n\u200a=\u200a147\/326) vorhanden.<\/jats:p><jats:p>\n          Schlussfolgerung\u2002Unsere Studie zeigt, dass die angewandten Standards zur prophylaktischen Antibiotikatherapie bei \u00d6sophagusvarizenblutungen in Deutschland stark variieren. Studien zur notwendigen Dauer der Prophylaxe und zur Abh\u00e4ngigkeit vom Stadium der Leberzirrhose k\u00f6nnten unn\u00f6tige Antibiotikagabe verhindern. Das Vermeiden einer Antibiotikaprophylaxe bei einem elektiven Banding von \u00d6sophagusvarizen, die nicht empfohlen und von knapp 20\u200a% der Teilnehmer durchgef\u00fchrt wird, k\u00f6nnte schon jetzt den Antibiotikaverbrauch reduzieren.<\/jats:p>","DOI":"10.1055\/a-1088-1502","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T23:48:50Z","timestamp":1581464930000},"page":"445-450","source":"Crossref","is-referenced-by-count":0,"title":["Aktueller Stand der Antibiotikaprophylaxe bei \u00d6sophagusvarizenblutungen in Deutschland"],"prefix":"10.1055","volume":"58","author":[{"given":"Irda","family":"Zhelegu","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Mannheim, II. Medizinische Klinik, Ruprecht-Karls-Universit\u00e4t Heidelberg Medizinische Fakult\u00e4t Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias Philip","family":"Ebert","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Mannheim, II. Medizinische Klinik, Ruprecht-Karls-Universit\u00e4t Heidelberg Medizinische Fakult\u00e4t Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Vogelmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsmedizin Mannheim, II. Medizinische Klinik, Ruprecht-Karls-Universit\u00e4t Heidelberg Medizinische Fakult\u00e4t Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM198810133191505","article-title":"Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. 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