{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:11Z","timestamp":1787004851002,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Corticotroph adenomas frequently harbor somatic USP8 mutations. These\nadenomas also commonly exhibit underexpression of P27, a cell cycle\nregulator. The present study aimed to determine the influence of USP8\nmutations on clinical features of Cushing\u02bcs disease and to elucidate the\nrelationship between USP8 mutations and P27 underexpression in these\ntumors. Retrospective study with 32 patients with Cushing\u02bcs disease was\nfollowed at the Ribeirao Preto Medical School University Hospital. We\nevaluated the patients\u02bc clinical data, the USP8 mutation status and\nthe gene expression of cell cycle regulators P27\/CDKN1B,\nCCNE1, CCND1, CDK2, CDK4, and CDK6 in\ntumor tissue in addition to the protein expression of\nP27\/CDKN1B. We observed somatic mutations in the exon 14\nof USP8 in 31.3% of the patients. Larger tumor size was\nobserved in patients harboring USP8 mutations (p=0.04), with\nsimilar rates of remission, age of presentation, salivary cortisol at 23:00\nh and after 1 mg dexamethasone, ACTH levels, and early postoperative plasma\ncortisol. We observed no differences regarding the gene or protein\nexpression of the cell cycle regulators according to USP8 mutation\nstatus. In this Brazilian series, the observed frequency of USP8\nsomatic mutations was similar to that reported in European ancestry\npopulations. Although it was reasonable that USP8 mutations could\ncontribute to cell cycle dysregulation and P27 underexpression in\ncorticotroph adenomas, our data did not confirm this hypothesis. It is\npossible that increased deubiquitinase activity observed in mutated\nUSP8 might influence other pathways related to cell growth and\nproliferation.<\/jats:p>","DOI":"10.1055\/a-1089-7806","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T19:14:06Z","timestamp":1581621246000},"page":"117-123","source":"Crossref","is-referenced-by-count":19,"title":["USP8 Mutations and Cell Cycle Regulation in Corticotroph Adenomas"],"prefix":"10.1055","volume":"52","author":[{"given":"Clarissa Silva","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School,\nUniversity of Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Costa","family":"Camargo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School,\nUniversity of Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Borchers","family":"Coeli-Lacchini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School,\nUniversity of Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano Pinto","family":"Saggioro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ribeirao Preto Medical School, University of\nSao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrton Custodio","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School,\nUniversity of Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School,\nUniversity of Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,2,13]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1089-7806.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T19:14:17Z","timestamp":1581621257000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1089-7806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1089-7806","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}