{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:36:07Z","timestamp":1774420567762,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n            Purpose\u2002Analysis of the influence of the singular risk factors age and breast density on the 2-year incidence of breast cancer among participants in the German mammography screening program.<\/jats:p><jats:p>\n            Materials and Methods\u2002The multicenter study includes 111\u200a456 subsequent round digital mammographic screening examinations from four screening units with prospective visual categorization of breast density. Based on detection in screening and during the 2-year interval after negative screening participation (interval cancers), 2-year breast cancer incidences (2\u00a0YBCI) (\u2030) were calculated in the 5-year age groups (5 YAG) of the target group 50\u201369 years and in the BI-RADS density categories ACR 1\u20134. Multivariate statistical evaluations were carried out using logistic regression models.<\/jats:p><jats:p>\n            Results\u2002With an increase in the 5 YAG, the 2 YBCI increased by 5.0\u200a\u2030, 6.7\u200a\u2030, 8.5\u200a\u2030 to 9.7\u200a\u2030, and was significantly different among 55\u201359, 60\u201364 and 65\u201369-year-old women compared to the youngest reference group 50\u201354 years (odds ratio (OR): 1.34; 1.68; and 1.93; p-value &lt;\u200a0.0001). With an increase in density categories 1\u20134, the 2 YBCI increased from 2.6\u200a\u2030, to 5.8\u200a\u2030, 9.6\u200a\u2030, and 9.7\u200a\u2030. The 2 YBCI differed significantly in breast density categories 2, 3, 4 from reference group 1 (OR: 2.17; 3.65; and 3.76; p-value &lt;\u200a0.0001). Only within the two main breast density groups 2 (frequency 44.3\u200a%) and 3 (44.7\u200a%), a significant increase in the 2 YBCI was observed across the 5 YAG (category 2: 3.7\u20138.9\u200a\u2030; category 3: 5.8\u201311.7\u200a\u2030; p-value &lt;\u200a0.001 each). The 2 YBCI was above the median of 7.5\u200a\u2030 in women with breast density category 2 and aged 65\u201369 years, as well as in women with breast density categories 3 and 4 aged 55\u201369 years. A 2 YBCI below the median was seen in women between 50\u201354 years regardless of breast density, as well as women in category 1 in all age groups.<\/jats:p><jats:p>\n            Conclusion\u2002Within the main breast density categories 2 and 3 (almost 90\u200a% of participants), incidences increase with age to double. A consistently low incidence is found regardless of breast density at a young screening age and in women with the lowest breast density.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1100-0016","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T23:37:41Z","timestamp":1582846661000},"page":"678-685","source":"Crossref","is-referenced-by-count":8,"title":["Stratification of Breast Cancer Risk in Terms of the Influence of Age and Mammographic density"],"prefix":"10.1055","volume":"192","author":[{"given":"Stefanie","family":"Weigel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Radiology and Reference Center for Mammography M\u00fcnster, University and University Hospital M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Heindel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Radiology and Reference Center for Mammography M\u00fcnster, University and University Hospital M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dietz","sequence":"additional","affiliation":[{"name":"Screening Unit, Leverkusen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Meyer-Johann","sequence":"additional","affiliation":[{"name":"Screening Unit, Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Graewingholt","sequence":"additional","affiliation":[{"name":"Screening Unit, Paderborn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Werner","family":"Hense","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Social Medicine, University of M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,27]]},"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden Verfahren"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1100-0016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T22:31:34Z","timestamp":1593729094000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1100-0016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,7,2]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1100-0016","relation":{},"ISSN":["1438-9029","1438-9010"],"issn-type":[{"value":"1438-9029","type":"print"},{"value":"1438-9010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]}}}