{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:21:56Z","timestamp":1776921716974,"version":"3.51.2"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Purpose The aim of our study was to evaluate the positive effect of\n                    starting an IV oxytocin infusion early before uterine incision on intraoperative\n                    blood loss.<\/jats:p><jats:p>\n                    Methods A total of 101 women between 18\u201340 years who underwent a\n                    primary elective cesarean section (CS) were included in this randomized\n                    controlled trial. The patients were divided into two groups. In Group I\n                    (n=51), oxytocin infusion was administered immediately after incision of\n                    the visceral peritoneum during CS. In Group II (n=50), infusion was\n                    administered immediately after clamping the umbilical cord. The primary outcome\n                    was the mean volume of blood loss during CS. The secondary outcomes included the\n                    mean reduction in hemoglobin and hematocrit levels, need for additional\n                    uterotonics and hemostatic uterine sutures, blood transfusion, post-operative\n                    pain score, and additional surgical procedures.<\/jats:p><jats:p>\n                    Results There were statistical significant differences either in the\n                    change of the hemoglobin concentration (1.27\u00b10.75 vs.1.74\u00b10.81;\n                    p&lt;0.01) or in the change of hematocrit concentration (3.89\u00b12.24\n                    vs. 5.41\u00b12.93; p&lt;0.01). Intraoperative blood loss was\n                    significantly lower in Group I when compared to Group II (475.86\u00b1150.11\n                    vs. 605.1\u00b1203.2; p&lt;0.01).<\/jats:p><jats:p>\n                    Conclusions Our findings suggest that the starting IV oxytocin infusion\n                    early before uterine incision reduces intraoperative blood loss. This could be\n                    effective to replace starting IV oxytocin infusion late after umbilical cord\n                    clamping or delivery of the placenta.<\/jats:p>","DOI":"10.1055\/a-1108-2017","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:16:24Z","timestamp":1583194584000},"page":"275-280","source":"Crossref","is-referenced-by-count":5,"title":["Less Blood Loss by Earlier Oxytocin Infusion in Cesarean Sections? A\n                    Randomized Controlled Trial"],"prefix":"10.1055","volume":"224","author":[{"given":"Taha","family":"Takmaz","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0306-6422","authenticated-orcid":false,"given":"Pinar","family":"Ozcan","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Sevket","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Filiz Gokmen","family":"Karasu","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevde Havva","family":"Islek","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belfin Nur Arici","family":"Halici","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/AOG.0000000000002351","article-title":"ACOG Practice Bulletin No. 183: Postpartum-Hemorrhage","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"key":"ref3","volume-title":"WHO recommendations for the prevention and treatment of postpartum\n                    haemorrhage","year":"2012"},{"key":"ref4","first-page":"106","article-title":"Prevention and management of postpartum haemorrhage: Green-top Guideline No\n                    52","volume":"358","author":"E Mavrides","year":"2016","journal-title":"BJOG"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejogrb.2015.12.012","article-title":"Postpartum hemorrhage: guidelines for clinical practice from the French College\n                    of Gynaecologists and Obstetricians (CNGOF): In collaboration with the French\n                    Society of Anesthesiology and Intensive Care (SFAR)","volume":"198","author":"L Sentilhes","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref6","first-page":"1952","article-title":"Is cephalad-caudad blunt expansion of the low transverse uterine incision really\n                    associated with less uncontrolled extensions to decrease intra-operative blood\n                    loss? A prospective randomised-controlled trial","volume":"29","author":"P Ozcan","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4103\/0019-5049.71020","article-title":"Are we using right dose of oxytocin?","volume":"54","author":"D Devikarani","year":"2010","journal-title":"Indian J Anaesth"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"34.e1","DOI":"10.1016\/j.ajog.2007.12.015","article-title":"Effects of oxytocin-induced uterine hyperstimulation during labor on fetal\n                    oxygen status and fetal heart rate patterns","volume":"199","author":"K R Simpson","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/AOG.0b013e3181aef106","article-title":"ACOG Practice Bulletin No. 106: Intrapartum fetal heart rate monitoring:\n                    nomenclature, interpretation, and general management principles","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1080\/14767058.2018.1471461","article-title":"The effect of initiating intravenous oxytocin infusion before uterine incision\n                    on the blood loss during elective cesarean section: a randomized clinical\n                    trial","volume":"32","author":"A A Abdelaleem","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref11","first-page":"77","article-title":"Factors associated with hemorrhage in caesarean deliveries","volume":"77","author":"C A Combs","year":"1991","journal-title":"Obstet Gynecol"},{"key":"ref12","first-page":"328","article-title":"Effect of type of anesthesia on blood loss at cesarean section","volume":"69","author":"L C Gilstrap","year":"1987","journal-title":"Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/0002-9378(88)90440-1","article-title":"Utilization of red blood cell transfusion in an obstetric setting","volume":"159","author":"A A Kamani","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3109\/14767058.2013.770458","article-title":"Parietal peritoneal closure vs. non-closure at caesarean section: which\n                    technique is feasible to perform?","volume":"26","author":"S K Altinbas","year":"2013","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1108-2017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T06:46:49Z","timestamp":1611643609000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1108-2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":13,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,10,19]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1108-2017","relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]}}}