{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T11:56:20Z","timestamp":1648641380527},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An\u00e4sthesiol Intensivmed Notfallmed Schmerzther"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Sepsis ist eine h\u00e4ufige und schwere Erkrankung mit vielf\u00e4ltigen pathophysiologischen Ver\u00e4nderungen. Wiederholt wurde versucht, mit neuen Therapieans\u00e4tzen den Verlauf der Sepsis positiv zu beeinflussen. Als neue Therapieoption r\u00fcckte in den letzten Jahren Vitamin C in den Fokus der Sepsisforschung. Ob Vitamin C diese Hoffnungen erf\u00fcllen kann, soll in diesem Beitrag erl\u00e4utert werden.<\/jats:p>","DOI":"10.1055\/a-1109-4363","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T22:31:28Z","timestamp":1622068288000},"page":"374-382","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin C \u2013 neue Therapiem\u00f6glichkeit bei Sepsis?"],"prefix":"10.1055","volume":"56","author":[{"given":"Stefan","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wiesmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinnerk","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Arndt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00134-017-4980-0","article-title":"Incidence of severe sepsis and septic shock in German intensive care units: the prospective,multicentre INSEP study","volume":"44","author":"G Marx","year":"2018","journal-title":"Intensive Care Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3390\/jcm8040478","article-title":"Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock. 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