{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:20:59Z","timestamp":1784092859808,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hypophysitis (PH) is a rare autoimmune inflammatory disease of the\n                        pituitary gland. The aim of the study was to evaluate clinical\n                        characteristics, disease management, and outcomes of cases with PH. Medical\n                        records of PH patients admitted to Hacettepe University Hospital between\n                        1999 and 2017 were analyzed retrospectively. Paraffin-embedded pathology\n                        blocks were obtained for both re-examination and IgG4 immunostaining. Twenty\n                        PH patients (15 females, 5 males) were evaluated. Mean age at diagnosis was\n                        41.5\u00b113.4 years. Some form of hormonal disorder was present in\n                        63.2% of cases, hypogonadism (66.6%) being the most common.\n                        Panhypopituitarism was present in 36.8%. All patients had pituitary\n                        gland enlargement on magnetic resonance imaging; stalk thickening and loss\n                        of neurohypophyseal bright spot were present in 17.6 and 23.5%,\n                        respectively. Lymphocytic hypophysitis was the most common histopathological\n                        subtype (50%). Among pathology specimens available for IgG and IgG4\n                        immunostaining (n=10), none fulfilled the criteria for IgG4-related\n                        hypophysitis. Four patients were given glucocorticoid treatment in diverse\n                        protocols; as initial therapy in 3. Sixteen cases underwent surgery, 7 of\n                        whom due to neuro-ophthalmologic involvement. Only 1 patient was observed\n                        without any intervention. Reduction of pituitary enlargement was seen in all\n                        surgical and glucocorticoid treated cases. None of the surgical patients\n                        showed hormonal improvement while one case in glucocorticoid group improved.\n                        PH should be considered in the differential diagnosis of sellar masses\n                        causing hormonal deficiencies. MRI findings are usually helpful, but not yet\n                        sufficient for definitive diagnosis of PH. Treatment usually improves\n                        symptoms and reduces sellar masses while hormonal recovery is less\n                        common.<\/jats:p>","DOI":"10.1055\/a-1113-7777","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T22:43:30Z","timestamp":1586385810000},"page":"220-227","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Characteristics, Management, and Treatment Outcomes of\n                    Primary Hypophysitis: A Monocentric Cohort"],"prefix":"10.1055","volume":"52","author":[{"given":"Seda Hanife","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hacettepe University\n                    Medical School, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Soylemezoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hacettepe University Medical School, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman Nahit","family":"Sendur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hacettepe University\n                    Medical School, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Mut","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hacettepe University Medical School,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kader Karli","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hacettepe University Medical School, Ankara,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcuk","family":"Dagdelen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hacettepe University\n                    Medical School, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomris","family":"Erbas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Hacettepe University\n                    Medical School, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,8]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1113-7777.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T22:43:32Z","timestamp":1586385812000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1113-7777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,8]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1113-7777","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}