{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:52:17Z","timestamp":1777423937778,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100001659","name":"the Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["GrK1041"],"award-info":[{"award-number":["GrK1041"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apolipoprotein C3 is a lipid-binding protein with a pivotal role in\n                        triglyceride metabolism and inflammation. This 11-year follow-up study aimed\n                        to evaluate apolipoprotein C3 levels and other parameters as markers of\n                        hepatic steatosis, in a random, population-based cohort in southern Germany.\n                        In 2013, we selected and re-examined 406 study participants (193 women, 213\n                        men; average age 58.1\u00b111.3 years) from the original\n                        \u201cEchinococcus multilocularis and other internal diseases in\n                        Leutkirch I\u201c (EMIL I) cohort studied in 2002. All participants\n                        received upper abdominal sonography to grade potential hepatic steatosis,\n                        and blood tests to determine apolipoprotein C3 levels and other laboratory\n                        parameters. Body mass index, waist-to-hip ratio, and anthropometric measures\n                        were documented. The follow-up study conducted in 2013 included a partial\n                        correlation analysis. We found an association between hepatic steatosis and\n                        elevated apolipoprotein C3 levels (p&lt;0.0001). Study participants\n                        with a novel diagnosis of hepatic steatosis had the highest apolipoprotein\n                        C3 serum levels (p=0.0002). Hepatic steatosis was associated with\n                        low levels of high density lipoprotein cholesterol (p=0.0374), high\n                        levels of total cholesterol (p=0.0117), increased homeostasis model\n                        assessment of insulin resistance (p=0.0002), elevated alanine\n                        transaminase (p&lt;0.0001), elevated aspartate transaminase\n                        (p=0.0003), and elevated C-reactive protein (p=0.0446).\n                        Apolipoprotein C3 serum levels were associated with the presence, disease\n                        grade, and new development of hepatic steatosis likewise to biomarkers of\n                        the metabolic syndrome.<\/jats:p>","DOI":"10.1055\/a-1116-2333","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:21:31Z","timestamp":1582935691000},"page":"236-245","source":"Crossref","is-referenced-by-count":2,"title":["Association of Apolipoprotein C3 Levels and Hepatic Steatosis: A\n                    Follow-Up Study"],"prefix":"10.1055","volume":"52","author":[{"given":"Patrick","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Ulm, Ulm,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard Otto","family":"Boehm","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University,\n                    Singapore"},{"name":"Imperial College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Schmidberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Ulm, Ulm,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Ulm, Ulm,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the EMIL-Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,28]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1116-2333.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T22:43:39Z","timestamp":1586385819000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1116-2333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,28]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,8]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1116-2333","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,28]]}}}