{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:26:16Z","timestamp":1779200776615,"version":"3.51.4"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The Else Kr\u00f6ner-Fresenius Stiftung in support of the German\n Conn\u2019s Registry-Else-Kr\u00f6ner Hyperaldosteronism Registry","award":["2013_A182 and 2015_A171 to MR"],"award-info":[{"award-number":["2013_A182 and 2015_A171 to MR"]}]},{"name":"The European Research Council (ERC) under the European Union\u2019s\n Horizon 2020 research and innovation programme","award":["Grant agreement No 694913"],"award-info":[{"award-number":["Grant agreement No 694913"]}]},{"DOI":"10.13039\/501100001659","name":"The Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["CRC\/Transregio 205\/1"],"award-info":[{"award-number":["CRC\/Transregio 205\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"Abstract<\/jats:title>First described in 1955 by Jerome W. Conn, primary aldosteronism (PA) today is\n well established as a relevant cause of secondary hypertension and accounts for\n about 5\u201310 % of hypertensives. The importance of considering PA\n is based on its deleterious target organ damage far beyond the effect of\n elevated blood pressure and on PA being a potentially curable form of\n hypertension. Aside the established contributory role of high dietary salt\n intake to arterial hypertension and cardiovascular disease, high salt intake is\n mandatory for aldosterone-mediated deleterious effects on target-organ damage in\n patients with primary aldosteronism. Consequently, counselling patients on the\n need to reduce salt intake represents a major component in the treatment of PA\n to minimize cardiovascular damage. Unfortunately, in PA patients salt intake is\n high and far beyond the target values of 5\u2009g per day, recommended by the\n World Health Organization. Insufficient patient motivation for lifestyle\n interventions can be further complicated by enhancing effects of aldosterone on\n salt appetite, via central and gustatory pathways. In this context, treatment\n for PA by adrenalectomy results in a spontaneous decrease in dietary salt intake\n and might therefore provide further reduction of cardiovascular risk in PA than\n specific medical treatment alone. Furthermore, there is evidence from clinical\n studies that even after sufficient treatment of PA dietary salt intake remains a\n relevant prognostic factor for cardiovascular risk. This review will focus on\n the synergistic benefits derived from both blockade of aldosterone-mediated\n effects and reduction in dietary salt intake on cardiovascular risk.<\/jats:p>","DOI":"10.1055\/a-1116-2407","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T23:02:53Z","timestamp":1586214173000},"page":"386-393","source":"Crossref","is-referenced-by-count":10,"title":["Salt Appetite and its Effects on Cardiovascular Risk in Primary\n Aldosteronism"],"prefix":"10.1055","volume":"52","author":[{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Handgriff","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU M\u00fcnchen, Munich,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,4,6]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1116-2407.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T22:31:34Z","timestamp":1592346694000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1116-2407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1116-2407","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]}}}