{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T05:48:01Z","timestamp":1648964881582},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Einleitung Exzessive Gewichtszunahme (EGZ) stellt einen Risikofaktor in der Schwangerschaft dar. Da die EGZ ebenso wie Hypertensive Schwangerschaftserkrankungen (HES) und die intrauterine Wachstumsrestriktion (IUGR) mit ver\u00e4nderten Konzentrationen Apolipoprotein B- (ApoB) haltiger Lipoproteine einhergehen, wurde der Hypothese nachgegangen, ob die ApoB-Konzentration im ersten Trimester diese Ereignisse vorhersagen kann.<\/jats:p><jats:p>Methoden Von 547 Schwangeren zeigten 95 eine unzureichende, 171 eine empfohlene und 281 eine EGZ. 23 Schwangere wiesen eine HES, 67 ein small for gestational age (SGA) Neugeborenes und sieben eine IUGR auf. Die ApoB-Konzentration wurden mittels ELISA in Serum der 11+0 bis 13+6 SSW bestimmt.<\/jats:p><jats:p>Ergebnisse Die mittleren ApoB-Konzentrationen der Patientinnen verschiedener Gewichtszunahme-Gruppen waren nicht signifikant unterschiedlich. Frauen mit Adipositas zeigten h\u00f6here ApoB-Konzentrationen als normalgewichtige (p&lt;0,001). Patientinnen mit pr\u00e4existentem Hypertonus sowie Raucherinnen wiesen erh\u00f6hte ApoB-Konzentrationen verglichen mit normotensiven Kontrollen (p=0,0015) und Nichtraucherinnen (p=0,0118) auf. Eine prognostische Bedeutung lie\u00df sich in Bezug auf HES und IUGR\/SGA nicht nachweisen.<\/jats:p><jats:p>Folgerung Die ApoB-Konzentration im ersten Trimester ist nicht f\u00fcr die Vorhersage einer EGZ oder Schwangerschaftskomplikation geeignet. Bei bestehenden pathologischen Zust\u00e4nden wie Rauchen, Adipositas und chronischer Hypertonie sind die ApoB-Werte erh\u00f6ht und k\u00f6nnten in diesen Gruppen zur Pathogenese von Schwangerschaftserkrankungen beitragen.<\/jats:p>","DOI":"10.1055\/a-1118-4084","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:43:26Z","timestamp":1583973806000},"page":"348-354","source":"Crossref","is-referenced-by-count":0,"title":["Exzessive Gewichtszunahme in der Schwangerschaft und die prognostische Bedeutung des Apolipoprotein B"],"prefix":"10.1055","volume":"224","author":[{"given":"Sophia-Marie","family":"Bohlen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Eckmann-Scholz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Rath","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolai","family":"Maass","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1093\/ajcn\/57.4.494","article-title":"Longitudinal assessment of energy expenditure in pregnancy by the doubly labeled water method","volume":"57","author":"G R Goldberg","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1233S","DOI":"10.1093\/ajcn\/71.5.1233s","article-title":"Pregnancy weight gain. 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