{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:47:13Z","timestamp":1790891233577,"version":"4.1.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Per-oral endoscopic myotomy (POEM) is associated with a short-term clinical response of 82\u200a% to 100\u200a% in treatment of patients with achalasia. Data are limited on the long-term durability of the clinical response in these patients. The aim of this study was to determine the long-term outcomes of patients undergoing POEM for management of achalasia.<\/jats:p><jats:p>\n          Methods\u2002This was a retrospective multicenter cohort study of consecutive patients who underwent POEM for management of achalasia. Patients had a minimum of 4\u2005years follow-up.\u200aClinical response was defined by an Eckardt score \u2264\u200a3.<\/jats:p><jats:p>\n          Results\u2002A total of 146 patients were included from 11 academic medical centers. Mean (\u00b1\u200aSD) age was 49.8 (\u00b1\u200a16) years and 79 (54\u200a%) were female. The most common type of achalasia was type II, seen in 70 (47.9\u200a%) patients, followed by type I seen in 41 (28.1\u200a%) patients. Prior treatments included: pneumatic dilation in 29 (19.9\u200a%), botulinum toxin injection in 13 (8.9\u200a%) and Heller myotomy in seven patients (4.8\u200a%). Eight adverse events occurred (6 mucosotomies, 2 pneumothorax) in eight patients (5.5\u200a%). Median follow-up duration was 55 months (IQR 49.9\u201360.6). Clinical response was observed in 139 (95.2\u200a%) patients at follow-up of \u2265\u200a48 months. Symptomatic reflux after POEM was seen in 45 (32.1\u200a%) patients, while 35.3\u200a% of patients were using daily PPI at 48 months post POEM. Reflux esophagitis was noted in 16.8\u200a% of patients who underwent endoscopy.<\/jats:p><jats:p>\n          Conclusion\u2002POEM is a durable and safe procedure with an acceptably low adverse event rate and an excellent long-term clinical response.<\/jats:p>","DOI":"10.1055\/a-1120-8125","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T22:56:46Z","timestamp":1587164206000},"page":"E650-E655","source":"Crossref","is-referenced-by-count":39,"title":["Long-term outcomes of per-oral endoscopic myotomy in achalasia patients with a minimum follow-up of 4\u2005years: a multicenter study"],"prefix":"10.1055","volume":"08","author":[{"given":"Olaya I.","family":"Brewer Gutierrez","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Familiari","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit \u2013 Gemelli University Hospital,Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad H.","family":"Dbouk","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Costamagna","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit \u2013 Gemelli University Hospital,Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yervant","family":"Ichkhanian","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Seewald","sequence":"additional","affiliation":[{"name":"Center of Gastroenterolgy Hirslanden Private Clinic Group Witellikerstrasse 40, 8032 Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Bapaye","sequence":"additional","affiliation":[{"name":"Shivanand Desai Centre for Digestive Disorders, Deenanath Mangeshkar Hospital and Research Centre, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, CHA Bundang Hospital, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Barret","sequence":"additional","affiliation":[{"name":"Department of gastroenterology, Cochin Hospital Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"Eleftheriadis","sequence":"additional","affiliation":[{"name":"Metropolitan Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Gastroenterology unit\/unit of functional disease and digestive physiology, Edouard Herriot hospital, Lion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu' Hussain","family":"Hayee","sequence":"additional","affiliation":[{"name":"Institute of Therapeutic Endoscopy, King\u02bcs College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Tantau","sequence":"additional","affiliation":[{"name":"Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ujiki","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem\/University of Chicago Medical Center, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Landi","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit \u2013 Gemelli University Hospital,Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Center of Gastroenterolgy Hirslanden Private Clinic Group Witellikerstrasse 40, 8032 Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center, CHA Bundang Hospital, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Roman","sequence":"additional","affiliation":[{"name":"Gastroenterology unit\/unit of functional disease and digestive physiology, Edouard Herriot hospital, Lion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn","family":"Haji","sequence":"additional","affiliation":[{"name":"Institute of Therapeutic Endoscopy, King\u02bcs College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Mason","family":"Hedberg","sequence":"additional","affiliation":[{"name":"NorthShore University HealthSystem\/University of Chicago Medical Center, Chicago, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Parsa","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Mion","sequence":"additional","affiliation":[{"name":"Gastroenterology unit\/unit of functional disease and digestive physiology, Edouard Herriot hospital, Lion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Fayad","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumbhari","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Agarwalla","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saowanee","family":"Ngamruengphong","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Sanaei","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Ponchon","sequence":"additional","affiliation":[{"name":"Gastroenterology unit\/unit of functional disease and digestive physiology, Edouard Herriot hospital, Lion, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen A.","family":"Khashab","sequence":"additional","affiliation":[{"name":"Division of gastroenterology and hepatology Johns Hopkins Hospital, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,17]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1120-8125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T22:56:59Z","timestamp":1587164219000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1120-8125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,4,17]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1120-8125","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]}}}