{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:35:35Z","timestamp":1787063735466,"version":"build-2736575974"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The European Research Council (ERC) under the European\n                        Union\u2019s Horizon 2020 research and innovation\n                        programme","award":["grant agreement No. 694913"],"award-info":[{"award-number":["grant agreement No. 694913"]}]},{"DOI":"10.13039\/501100001659","name":"The Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["Projektnummer: 314061271-TRR 205"],"award-info":[{"award-number":["Projektnummer: 314061271-TRR 205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary aldosteronism (PA) is the most common form of endocrine hypertension.\n                    Agonistic autoantibodies against the angiotensin II type 1 receptor\n                        (AT1R-Abs) have been described in transplantation medicine and\n                    women with pre-eclampsia and more recently in patients with PA. Any functional\n                    role of AT1R-Abs in either of the two main subtypes of PA\n                    (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires\n                    clarification. In this review, we discuss the studies performed to date on\n                        AT1R-Abs in PA.<\/jats:p>","DOI":"10.1055\/a-1120-8647","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T19:51:26Z","timestamp":1584129086000},"page":"379-385","source":"Crossref","is-referenced-by-count":13,"title":["Angiotensin II Type 1 Receptor Autoantibodies in Primary\n                    Aldosteronism"],"prefix":"10.1055","volume":"52","author":[{"given":"Lucie S.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, LMU M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, LMU M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, LMU M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy Ann","family":"Williams","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, LMU M\u00fcnchen, Germany"},{"name":"Division of Internal Medicine and Hypertension, Department of Medical\n                    Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.HYP.0000040261.30455.B6","article-title":"Hyperaldosteronism among black and white subjects with resistant\n                    hypertension","volume":"40","author":"D A Calhoun","year":"2002","journal-title":"Hypertension"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1125\n                    hypertensive patients","volume":"48","author":"G P Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in\n                    primary care practice","volume":"69","author":"S Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2013-2805","article-title":"Long-term cardio- and cerebrovascular events in patients with primary\n                    aldosteronism","volume":"98","author":"P Mulatero","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/HYPERTENSIONAHA.113.01060","article-title":"Cardiovascular complications associated with primary aldosteronism: a controlled\n                    cross-sectional study","volume":"62","author":"S Savard","year":"2013","journal-title":"Hypertension"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/HYPERTENSIONAHA.107.095448","article-title":"Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in\n                    patients with primary aldosteronism","volume":"50","author":"C Catena","year":"2007","journal-title":"Hypertension"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1210\/er.2017-00189","article-title":"Genetic causes of functional adrenocortical adenomas","volume":"38","author":"M C Zennaro","year":"2017","journal-title":"Endocr Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/HYPERTENSIONAHA.117.10111","article-title":"Old and new concepts in the molecular pathogenesis of primary aldosteronism","volume":"70","author":"ET A Prada","year":"2017","journal-title":"Hypertension"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00281-014-0425-9","article-title":"Agonistic autoantibodies directed against G-protein-coupled receptors and their\n                    relationship to cardiovascular diseases","volume":"36","author":"G Wallukat","year":"2014","journal-title":"Semin Immunopathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.1221820110","article-title":"Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in\n                    chemistry","volume":"110","author":"R B Clark","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature08144","article-title":"The structure and function of G-protein-coupled receptors","volume":"459","author":"D M Rosenbaum","year":"2009","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molmed.2010.11.004","article-title":"Therapeutic potential of beta-arrestin- and G protein-biased agonists","volume":"17","author":"E J Whalen","year":"2011","journal-title":"Trends Mol Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"113647","DOI":"10.1016\/j.bcp.2019.113647","article-title":"The nature of efficacy at G protein-coupled receptors","volume":"170","author":"P Zhao","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fendo.2019.00519","article-title":"The Role of beta-Arrestin Proteins in Organization of Signaling and Regulation\n                    of the AT1 Angiotensin Receptor","volume":"10","author":"G Turu","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phrs.2017.05.009","article-title":"Biased agonism\/antagonism at the AngII-AT1 receptor: Implications for\n                    adrenal aldosterone production and cardiovascular therapy","volume":"125","author":"J Maning","year":"2017","journal-title":"Pharmacol Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.molcel.2006.11.007","article-title":"New roles for beta-arrestins in cell signaling: not just for seven-transmembrane\n                    receptors","volume":"24","author":"R J Lefkowitz","year":"2006","journal-title":"Mol Cell"},{"key":"ref17","first-page":"56","article-title":"Angiotensin II type-2 receptor-specific effects on the cardiovascular\n                    system","volume":"2","author":"Y Li","year":"2012","journal-title":"Cardiovasc Diagn Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/HYPERTENSIONAHA.117.10552","article-title":"Role of AT2R (Angiotensin Type 2 Receptor) in maintaining sodium-potassium\n                    balance","volume":"71","author":"S Patel","year":"2018","journal-title":"Hypertension"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/HYPERTENSIONAHA.115.05428","article-title":"AT2R Autoantibodies Block Angiotensin II and AT1R Autoantibody-Induced\n                    Vasoconstriction","volume":"66","author":"C Liles","year":"2015","journal-title":"Hypertension"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"13293","DOI":"10.1038\/s41598-017-13746-w","article-title":"Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in\n                    rheumatoid arthritis synovium","volume":"7","author":"R Terenzi","year":"2017","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"134s","DOI":"10.1016\/j.amjhyper.2005.05.005","article-title":"How to explain the differences between renin angiotensin system modulators","volume":"18","author":"B I Levy","year":"2005","journal-title":"Am J Hypertens"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2017.00603","article-title":"Mechanisms of autoantibody-induced pathology","volume":"8","author":"R J Ludwig","year":"2017","journal-title":"Front 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Hypertens"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1111\/ajt.12395","article-title":"Higher risk of kidney graft failure in the presence of anti-angiotensin II\n                    type-1 receptor antibodies","volume":"13","author":"M Taniguchi","year":"2013","journal-title":"Am J Transplant"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/TP.0b013e3181fd97f1","article-title":"Anti-angiotensin type 1 receptor antibodies associated with antibody mediated\n                    rejection in donor HLA antibody negative patients","volume":"90","author":"N L Reinsmoen","year":"2010","journal-title":"Transplantation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/tri.12371","article-title":"The influence of non-HLA antibodies directed against angiotensin II type 1\n                    receptor (AT1R) on early renal transplant outcomes","volume":"27","author":"M Banasik","year":"2014","journal-title":"Transpl Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1056\/NEJMoa035717","article-title":"Angiotensin II type 1-receptor activating antibodies in renal-allograft\n                    rejection","volume":"352","author":"D Dragun","year":"2005","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1111\/ajt.12397","article-title":"Pretransplant sensitization against angiotensin II type 1 receptor is a risk\n                    factor for acute rejection and graft loss","volume":"13","author":"M Giral","year":"2013","journal-title":"Am J Transplant"},{"issue":"S 01","key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/nep.12421","article-title":"Angiotensin II type 1 receptor antibody precipitating acute vascular rejection\n                    in kidney transplantation","volume":"20","author":"A Jobert","year":"2015","journal-title":"Nephrology (Carlton)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/petr.12531","article-title":"De novo development of antibodies to kidney-associated self-antigens angiotensin\n                    II receptor type I, collagen IV, and fibronectin occurs at early time points\n                    after kidney transplantation in children","volume":"19","author":"L E Hesemann","year":"2015","journal-title":"Pediatr Transplant"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1750-1326-9-49","article-title":"Increase of angiotensin II type 1 receptor auto-antibodies in\n                    Huntington\u2019s disease","volume":"9","author":"D H Lee","year":"2014","journal-title":"Mol Neurodegener"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/ard.2010.135772","article-title":"Involvement of functional autoantibodies against vascular receptors in systemic\n                    sclerosis","volume":"70","author":"G Riemekasten","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/jch.13351","article-title":"Evaluation of angiotensin II type-1 receptor antibodies in primary aldosteronism\n                    and further considerations about their possible pathogenetic role","volume":"20","author":"C Sabbadin","year":"2018","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.kint.2019.01.030","article-title":"Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a\n                    distinctive phenotype of antibody-mediated rejection in kidney transplant\n                    recipients","volume":"96","author":"C Lefaucheur","year":"2019","journal-title":"Kidney Int"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/HYPERTENSIONAHA.119.13388","article-title":"AT1AA (Angiotensin II Type-1 Receptor Autoantibodies): Cause or Consequence of\n                    Human Primary Aldosteronism?","volume":"74","author":"M Piazza","year":"2019","journal-title":"Hypertension"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/HYPERTENSIONAHA.119.13156","article-title":"Diverse responses of autoantibodies to the Angiotensin II type 1 receptor in\n                    primary aldosteronism","volume":"74","author":"T A Williams","year":"2019","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1210\/jc.2013-3282","article-title":"Autoimmune mechanisms activating the angiotensin AT1 receptor in\n                    'primary' aldosteronism","volume":"99","author":"D C Kem","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jash.2014.10.009","article-title":"Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in\n                    primary aldosteronism","volume":"9","author":"H Li","year":"2015","journal-title":"J Am Soc Hypertens"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"E1625","DOI":"10.3390\/jcm8101625","article-title":"Preeclampsia: Risk Factors, Diagnosis, Management, and the Cardiovascular Impact\n                    on the Offspring","volume":"8","author":"R Fox","year":"2019","journal-title":"J Clin Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nm.1856","article-title":"Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant\n                    mice","volume":"14","author":"C C Zhou","year":"2008","journal-title":"Nat Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1161\/01.CIR.0000142855.68398.3A","article-title":"Antibodies from preeclamptic patients stimulate increased intracellular\n                    Ca2+ mobilization through angiotensin receptor activation","volume":"110","author":"T M Thway","year":"2004","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.HYP.0000256565.20983.d4","article-title":"Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with\n                    a history of preeclampsia","volume":"49","author":"C A Hubel","year":"2007","journal-title":"Hypertension"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/HYPERTENSIONAHA.109.140061","article-title":"Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia:\n                    correlation with disease severity","volume":"55","author":"A H Siddiqui","year":"2010","journal-title":"Hypertension"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1161\/01.CIR.0000058200.90059.B1","article-title":"AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH\n                    oxidase","volume":"107","author":"R Dechend","year":"2003","journal-title":"Circulation"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1097\/HJH.0b013e328304dbff","article-title":"Autoantibody against AT1 receptor from preeclamptic patients induces\n                    vasoconstriction through angiotensin receptor activation","volume":"26","author":"X Yang","year":"2008","journal-title":"J Hypertens"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/HYPERTENSIONAHA.111.171348","article-title":"Angiotensin II type 1 receptor antibodies and increased angiotensin II\n                    sensitivity in pregnant rats","volume":"58","author":"K Wenzel","year":"2011","journal-title":"Hypertension"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/HJH.0b013e3283376cc6","article-title":"Stimulating autoantibodies against the angiotensin II type 1 receptor are not\n                    associated with preeclampsia in Mexican-Mestizo women","volume":"28","author":"A Leanos-Miranda","year":"2010","journal-title":"J Hypertens"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2741\/4791","article-title":"Regulatory antibodies against GPCR in women ten years after early-onset\n                    preeclampsia","volume":"24","author":"A Birukov","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/HYPERTENSIONAHA.112.202945","article-title":"Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary\n                    aldosteronism as a result of aldosterone-producing adenoma","volume":"61","author":"G Rossitto","year":"2013","journal-title":"Hypertension"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an\n                    international consensus on outcome measures and analysis of remission rates in\n                    an international cohort","volume":"5","author":"T A Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.kint.2016.03.019","article-title":"Non-HLA antibodies against endothelial targets bridging allo- and\n                    autoimmunity","volume":"90","author":"D Dragun","year":"2016","journal-title":"Kidney Int"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000376546","article-title":"Questionable Validity of Peptide-Based ELISA Strategies in the Diagnostics of\n                    Cardiopathogenic Autoantibodies That Activate G-Protein-Coupled Receptors","volume":"131","author":"R Jahns","year":"2015","journal-title":"Cardiology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1210\/jcem-47-5-938","article-title":"Increased adrenal sensitivity to angiotensin II in idiopathic\n                    hyperaldosteronism","volume":"47","author":"M Wisgerhof","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jacc.2010.08.635","article-title":"Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction\n                    progression to heart failure and adverse remodeling via reduction of circulating\n                    aldosterone levels","volume":"57","author":"A Lymperopoulos","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1016\/j.jacc.2014.09.070","article-title":"Different potencies of angiotensin receptor blockers at suppressing adrenal\n                    beta-Arrestin1-dependent post-myocardial infarction hyperaldosteronism","volume":"64","author":"A Lymperopoulos","year":"2014","journal-title":"J Am Coll Cardiol"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1120-8647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T20:32:25Z","timestamp":1661286745000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1120-8647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":57,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1120-8647","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]}}}