{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:20:49Z","timestamp":1790144449111,"version":"4.0.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"E-DA Hospital","award":["EDPJ 99019"],"award-info":[{"award-number":["EDPJ 99019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>\n            Background\u2002Acute gastric variceal hemorrhage (AGVH) is a serious complication of portal hypertension. Endoscopic cyanoacrylate glue injection is standard therapy for acute hemostasis; however, it may be associated with serious complications. The role of thrombin injection has not been confirmed. This study compared endoscopic thrombin and glue injections in the hemostasis of AGVH.<\/jats:p><jats:p>\n            Methods\u200268 eligible patients with AGVH were randomized to receive thrombin injection (33 patients) or glue injection (35 patients). The primary end point was injection-induced gastric ulcers. Secondary end points were acute hemostasis, rebleeding, and mortality within 42 days.<\/jats:p><jats:p>\n            Results\u2002Both groups had comparable baseline data. Hemostasis of active bleeding at endoscopy was 90.0\u200a% (9\/10) in the thrombin group and 90.9\u200a% (10\/11) in the glue group (P\u200a=\u200a0.58), and 48-hour hemostasis was achieved in 93.9\u200a% (31\/33) and 97.1\u200a% (34\/35), respectively (P\u200a=\u200a0.60). Treatment failure at 5 days occurred in two patients (6.1\u200a%) in the thrombin group and two patients (5.7\u200a%) in the glue group (P\u200a&gt;\u200a0.99). Gastric ulcers occurred in none of the thrombin group and 11\/30 (36.7\u200a%) of the glue group (P\u200a&lt;\u200a0.001, 95\u200a% confidence interval [CI] 8\u200a%\u200a\u2013\u200a27\u200a%). Complications occurred in 4 (12.1\u200a%) and 18 (51.4\u200a%) patients in the thrombin and glue groups, respectively (P\u200a&lt;\u200a0.001, 95\u200a%CI 22\u200a%\u200a\u2013\u200a45\u200a%). Two patients who received glue had post-treatment gastric ulcer bleeding. One patient in each group died.<\/jats:p><jats:p>\n            Conclusions\u2002Endoscopic thrombin injection was similar to glue injection in achieving successful hemostasis of AGVH. However, a higher incidence of complications may be associated with glue injection.<\/jats:p>","DOI":"10.1055\/a-1127-3170","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:01:20Z","timestamp":1586905280000},"page":"548-555","source":"Crossref","is-referenced-by-count":46,"title":["A prospective, randomized trial of thrombin versus cyanoacrylate injection in the control of acute gastric variceal hemorrhage"],"prefix":"10.1055","volume":"52","clinical-trial-number":[{"clinical-trial-number":"nct01717612","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Gin-Ho","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"},{"name":"School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"},{"name":"Division of Gastroenterology, E-DA Hospital, Da-Chung Branch, Kaohsiung, Taiwan"},{"name":"School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ming","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"},{"name":"Division of Gastroenterology, E-DA Hospital, Da-Chung Branch, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daw-Shyong","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"},{"name":"Division of Gastroenterology, E-DA Hospital, Da-Chung Branch, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Hao","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"},{"name":"Division of Gastroenterology, E-DA Hospital, Da-Chung Branch, Kaohsiung, Taiwan"},{"name":"School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Division of Gastroenterology, E-DA Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,14]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1127-3170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T22:31:48Z","timestamp":1593037908000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1127-3170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,6,24]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1127-3170","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}