{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:25:24Z","timestamp":1788719124226,"version":"build-2803163510"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"clinical routine work"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Background The extensive use of antibiotics is reflected by an increasing\n                    prevalence of infections with multidrug-resistant bacteria, including\n                    third-generation cephalosporin-resistant bacteria (3GCRB). For neonatal\n                    intensive care units screening and enhanced barrier precautions are recommended\n                    to control the spread of multidrug-resistant Gram-negative bacteria, while\n                    evidence for efficacy of barrier precautions remains scarce in a non-outbreak\n                    setting.<\/jats:p><jats:p>\n                    Objective To determine the impact of a screening program for maternal\n                    3GCRB colonization and the effects of contact precautions and cohort nursing,\n                    concerning the risk of neonatal late-onset sepsis (LOS) and antibiotic use rates\n                    (AURs).<\/jats:p><jats:p>\n                    Study Design In a retrospective matched-pair cohort study, data of\n                    neonates exposed to maternal 3GCRB colonization were compared with findings in\n                    non-exposed neonates.<\/jats:p><jats:p>\n                    Results Of 3,144 neonates admitted, 184 neonates born to 3GCRB-positive\n                    mothers were eligible. Among them, 37 (20%) became 3GCRB positive during\n                    hospital stay. 3GCRB-exposed infants had a lower rate of LOS (6.5 vs.\n                    14.1%, p=0.03) and lower AURs in that time period compared to\n                    controls (mean 0.009 vs. 0.025, p=0.006). When started within the first\n                    72h after birth, days of therapy with meropenem were significantly lower in\n                    non-exposed vs. 3GCRB-exposed infants (mean 0.13 vs. 0.42; p=0.002). No\n                    invasive infections with 3GCRB occurred.<\/jats:p><jats:p>\n                    Conclusions Neonates of 3GCRB-positive mothers do not have an increased a\n                    priori risk for invasive 3GCRB infection and may benefit from enhanced contact\n                    precautions measures.<\/jats:p>","DOI":"10.1055\/a-1128-0524","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T22:59:06Z","timestamp":1586905146000},"page":"203-209","source":"Crossref","is-referenced-by-count":6,"title":["Screening for Third-Generation Cephalosporin-Resistant Bacteria\n                    Reduces the Incidence on Late-Onset Sepsis and Antibiotic use in\n                    Neonates"],"prefix":"10.1055","volume":"232","author":[{"given":"Ann Carolin","family":"Longardt","sequence":"additional","affiliation":[{"name":"Neonatology, Charit\u00e9 Universit\u00e4tsmedizin Berlin,\n                    Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brar","family":"Piening","sequence":"additional","affiliation":[{"name":"Institute of Hygiene and Environmental Medicine, Charit\u00e9\n                    University Medicine Berlin, Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"von Weizs\u00e4cker","sequence":"additional","affiliation":[{"name":"Obstetrics, Charit\u00e9 Universit\u00e4tsmedizin Berlin,\n                    Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Dame","sequence":"additional","affiliation":[{"name":"Neonatology, Charit\u00e9 Universit\u00e4tsmedizin Berlin,\n                    Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Neonatology, Charit\u00e9 Universit\u00e4tsmedizin Berlin,\n                    Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Garten","sequence":"additional","affiliation":[{"name":"Neonatology, Charit\u00e9 Universit\u00e4tsmedizin Berlin,\n                    Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,14]]},"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1128-0524.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:36:13Z","timestamp":1594679773000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1128-0524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,7,13]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1128-0524","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}