{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:52:17Z","timestamp":1661302337741},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Central Relay in Health and Disease\u201d, projects S01 to\n                        A.W.). Deutsche Krebshilfe","award":["no. 70112617 to A.W."],"award-info":[{"award-number":["no. 70112617 to A.W."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The adrenal gland integrates catecholamine-producing neuroendocrine cells and\n                    steroid-producing cells with mesenchymal origin in a structured manner under one\n                    capsule and is a key regulator for vital bioactivity. In addition to\n                    adrenal-specific disease, dysregulation of adrenal hormones is associated with\n                    systemic effects, leading to undesirable metabolic and cardiovascular\n                    consequences. Mass spectrometry imaging (MSI) technique can simultaneously\n                    measure a broad range of biomolecules, including metabolites and hormones, which\n                    has enabled the study of tissue metabolic and hormone alterations in adrenal and\n                    adrenal-related diseases. Furthermore, this technique coupled with labeled\n                    immunohistochemistry staining has enabled the study of the pathophysiological\n                    adaptation of the adrenal gland under normal and abnormal conditions at\n                    different molecular levels. This review discusses the recent applications of in\n                    situ MSI in the adrenal gland. For example, the combination of formalin-fixed\n                    paraffin-embedded tissue microarray and MSI to tissues from patient cohorts has\n                    facilitated the discovery of clinically relevant prognostic biomolecules and\n                    generated promising hypotheses for new sights into physiology and\n                    pathophysiology of adrenal gland. MSI also has enabled the discovery of\n                    clinically significant tissue molecular (i.\u2009e., biomarker) and pathway\n                    changes in adrenal disease, particularly in adrenal tumors. In addition, MSI has\n                    advanced the ability to optimally identify and detect adrenal gland specific\n                    molecules. Thus, as a novel analytical methodology, MSI has provided\n                    unprecedented capabilities for in situ tissue study.<\/jats:p>","DOI":"10.1055\/a-1129-6947","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T23:06:44Z","timestamp":1588201604000},"page":"435-447","source":"Crossref","is-referenced-by-count":3,"title":["In situ Metabolite Mass Spectrometry Imaging: New Insights into the\n                    Adrenal Gland"],"prefix":"10.1055","volume":"52","author":[{"given":"Fengxia","family":"Li","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Pathology, German Research Center for\n                    Environmental Health, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Feuchtinger","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Pathology, German Research Center for\n                    Environmental Health, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Walch","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Pathology, German Research Center for\n                    Environmental Health, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Pathology, German Research Center for\n                    Environmental Health, Helmholtz Zentrum M\u00fcnchen, M\u00fcnchen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,4,29]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1129-6947.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T22:31:41Z","timestamp":1592346701000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1129-6947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1129-6947","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]}}}