{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:57:15Z","timestamp":1783083435999,"version":"3.54.6"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction Our study aims to evaluate the perinatal outcomes in twin pregnancies diagnosed with intrahepatic cholestasis of pregnancy (ICP) and to compare these with normal healthy twin pregnancies for perinatal outcomes. The second outcome of the study was to determine whether in vitro fertilization-embryo transfer (IVF-ET) affects the perinatal outcome in ICP patients.<\/jats:p><jats:p>\nMaterials and Methods In this study, 59 ICP and 641 healthy twin pregnancies were compared for perinatal outcomes retrospectively. According to the mode of conception, the twin pregnancies with ICP were divided into 2 groups. The twin pregnancies with ICP who were conceived with IVF were referred to as the IVF-ET group. The twin pregnancies with ICP who were conceived spontaneously or by ovulation induction and intrauterine insemination (IUI) were referred to as the non-IVF-ET group.<\/jats:p><jats:p>\nResults Twin pregnancies with ICP give birth significantly earlier than normal twin pregnancies (p \u02c2 0.001). The diagnosis of ICP occurred significantly earlier in the IVF-ET pregnancy with ICP than in the non-IVF-ET group. In twin pregnancies with IVF-ET, patients delivered significantly earlier than in the non-IVF-ET group (p=0.002). Twin pregnancies with ICP were found to have significantly higher rates of meconium-stained amniotic fluid, postnatal intubation, and admission to the neonatal intensive care unit (NICU) than healthy twin pregnancies.<\/jats:p><jats:p>\nConclusions ICP is a risk factor for preterm delivery in twin pregnancies. In addition, ICP develops earlier and more frequently in twin pregnancies from IVF-ET than in those from non-IVF twin pregnancies, and the disease may be more serious.<\/jats:p>","DOI":"10.1055\/a-1129-7358","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T01:51:45Z","timestamp":1584755505000},"page":"34-38","source":"Crossref","is-referenced-by-count":12,"title":["The Impact of Assisted Reproductive Technology in Twin Pregnancies Complicated by Intrahepatic Cholestasis of Pregnancy: a Retrospective Cohort Study"],"prefix":"10.1055","volume":"225","author":[{"given":"Samettin","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Samsun Education and Research Hospital, Obstetrics and Gynecology, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"\u00c7al\u0131\u015fkan","sequence":"additional","affiliation":[{"name":"Samsun Education and Research Hospital, Obstetrics and Gynecology, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3748\/wjg.15.2049","article-title":"Intrahepatic cholestasis of pregnancy","volume":"15","author":"V Geenes","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref2","first-page":"1814","article-title":"Clinical analysis of 57 cases of intrahepatic cholestasis of pregnancy with twins","volume":"12","author":"S Liu","year":"2010","journal-title":"Sichuan Med"},{"key":"ref3","first-page":"1","article-title":"The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis","volume":"6","author":"G Pacella","year":"2015","journal-title":"J Matern Fetal Neontal Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/107155760200900103","article-title":"Intrahepatic cholestasis of pregnancy: an intriguing pregnancy-specific disorder","volume":"9","author":"A M Germain","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/hep.20336","article-title":"Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates","volume":"40","author":"A Glantz","year":"2004","journal-title":"Hepatology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/hep.26617","article-title":"Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population based case-control study","volume":"59","author":"V Geenes","year":"2014","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2014.07.026","article-title":"Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels","volume":"212","author":"L Brouwers","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"ref8","first-page":"535","article-title":"Maternal and fetal outcomes of women with intrahepatic cholestasis of pregnancy","volume":"51","author":"H Yang","year":"2016","journal-title":"Chin J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5603\/GP.2019.0039","article-title":"Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy","volume":"90","author":"S \u00c7elik","year":"2019","journal-title":"Ginekol Pol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/jog.13399","article-title":"Bile acid levels and risk of adverse perinatal outcomesin intrahepatic cholestasis of pregnancy: a meta-analysis","volume":"43","author":"D Cui","year":"2017","journal-title":"J Obstet Gynecol Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1080\/14767058.2017.1332036","article-title":"Perinatal outcomes associated with intrahepatic cholestasis of pregnancy","volume":"31","author":"C A Herrera","year":"2018","journal-title":"J Mat Fet Neonat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3109\/14767058.2015.1079612","article-title":"Perinatal outcomes with intrahepatic cholestasis of pregnancy in twin pregnancies","volume":"29","author":"X Liu","year":"2016","journal-title":"J Mat Fet Neonat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12884-018-1913-z","article-title":"Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy","volume":"18","author":"Y Mei","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1093\/humrep\/17.11.2897","article-title":"The course of pregnancy and delivery and the use of maternal healthcare services after standard IVF in Northern Finland 1990\u20131995","volume":"17","author":"S Koivurova","year":"2002","journal-title":"Human Reprod"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1038\/s41598-018-22387-6","article-title":"Impacts of different methods of conception on the perinatal outcome of intrahepatic cholestasis of pregnancy in twin pregnancies","volume":"8","author":"C Feng","year":"2018","journal-title":"Sci Rep"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1129-7358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T23:37:42Z","timestamp":1613691462000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1129-7358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":15,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,2,18]]},"published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1129-7358","relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]}}}