{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:48Z","timestamp":1793646948996,"version":"4.5.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2002Gastroesophageal reflux disease (GERD) is an important concern after peroral endoscopic myotomy (POEM). However, there are limited data on the risk factors for post-POEM GERD and its responsiveness to proton pump inhibitors (PPIs). In this study, we aimed to analyze the variables affecting the occurrence of GERD and its response to PPI therapy.<\/jats:p>\n                  <jats:p>Methods\u2002Consecutive patients with idiopathic achalasia who underwent POEM (December 2016 to January 2018) were evaluated for GERD using 24-hour pH impedance, esophagogastroduodenoscopy (EGD), and symptoms. Multivariate analysis was performed to identify the variables affecting the incidence of post-POEM GERD.<\/jats:p>\n                  <jats:p>Results\u2002A total of 209 patients with esophageal motility disorders, including 194 patients with non-sigmoid achalasia, underwent POEM during the study period. Comprehensive evaluation of GERD was completed on 167 patients (86.1\u200a%): 47.3\u200a% women with a mean (standard deviation) age of 41 (14.42) years and body mass index of 22.2 (3.89) kg\/m2; the majority (70.7\u200a%) were treatment na\u00efve. A high DeMeester score (&gt;\u200a14.72), reflux esophagitis, and symptomatic GERD were identified in 47.9\u200a%, 41.9\u200a%, and 29.3\u200a% of patients, respectively. On logistic regression analysis, type of achalasia, technique of POEM (anterior vs. posterior), pre- or post-POEM esophageal manometry variables, and patient characteristics were not associated with post-POEM GERD. Erosive esophagitis responded to PPI therapy in the majority of patients (81.4\u200a%).<\/jats:p>\n                  <jats:p>Conclusion\u2002The incidence of GERD is high after POEM. Most of the reflux esophagitis is mild and responsive to PPI therapy. There are no procedural or patient-related variables that appear to affect the incidence of post-POEM GERD.<\/jats:p>","DOI":"10.1055\/a-1133-4354","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T19:43:02Z","timestamp":1585078982000},"page":"643-651","source":"Crossref","is-referenced-by-count":68,"title":["Gastroesophageal reflux disease after peroral endoscopic myotomy is unpredictable, but responsive to proton pump inhibitor therapy: a large, single-center study"],"prefix":"10.1055","volume":"52","author":[{"given":"Zaheer","family":"Nabi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Kotla","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Tandan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Goud","sequence":"additional","affiliation":[{"name":"Department of Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Darisetty","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Venkat","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterologist, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,24]]},"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1133-4354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T18:32:06Z","timestamp":1595961126000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1133-4354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,24]]},"references-count":0,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2020,7,28]]},"published-print":{"date-parts":[[2020,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1133-4354","relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,24]]}}}